Evidence map›Paper›PMID 30954231›Full record

ArticleBiological psychiatry2019

Decreased Nociceptin Receptors Are Related to Resilience and Recovery in College Women Who Have Experienced Sexual Violence: Therapeutic Implications for Posttraumatic Stress Disorder.

Rajesh Narendran, Savannah Tollefson, Kelli Fasenmyer, Jennifer Paris, Michael L Himes, Brian Lopresti, Roberto Ciccocioppo, N Scott Mason

Open access · greenAbstract read
In one paragraph

Article in Biological psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.0field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Rajesh NarendranDepartment of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania; Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania. Electronic address: narendranr@upmc.edu.
Savannah TollefsonDepartment of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania.
Kelli FasenmyerDepartment of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania.
Jennifer ParisDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania.
Michael L HimesDepartment of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania.
Brian LoprestiDepartment of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania.
Roberto CiccocioppoSchool of Pharmacy, Pharmacology Unit, University of Camerino, Camerino, Italy.
N Scott MasonDepartment of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania.
University of Pittsburgh · USUniversità di Camerino · IT

Funding

University of Pittsburgh Clinical and Translational Science InstituteUL1TR001857 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2016 to 2025
$129.3M
PET Imaging of neurochemical transmission in cocaine use disordersR01DA026472 · NIDA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NARENDRAN, RAJESH · 2009 to 2025
$7.7M
Imaging Nociceptin Receptors in AlcoholismR01AA025247 · NIAAA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NARENDRAN, RAJESH · 2016 to 2019
$2.4M
NCATS NIH HHS UL1 TR001857NIAAA NIH HHS R01 AA025247NIDA NIH HHS R01 DA026472
6 · The paper itself

Abstract

backgroundPosttraumatic stress disorder (PTSD) is a stress disorder that develops in only some individuals following a traumatic event. Data suggest that a substantial fraction of women recover after sexual violence. Thus, the investigation of stress and antistress neuropeptides in this sample has the potential to inform the neurochemistry of resilience following trauma. Nociceptin is an antistress neuropeptide in the brain that promotes resilience in animal models of PTSD.

methods[

resultsNo differences in [

conclusionsDecreased midbrain and cerebellum nociceptin receptors are associated with less severe PTSD symptoms. Medications that target nociceptin should be explored to prevent and treat PTSD.

Indexed as

Resilience, PsychologicalAdultBrainCerebellumFemaleHumansMesencephalonNociceptin ReceptorPositron-Emission TomographyReceptors, OpioidSex OffensesStress Disorders, Post-TraumaticStudentsYoung AdultNociceptin ReceptorOPRL1 protein, humanReceptors, Opioid[(11)C]NOP-1ANociceptin/orphanin FQ peptide receptorsNOPsPETPositron emission tomographyPosttraumatic stress disorderResilienceSexual violence

Identifiers

PMID30954231
PMCPMC7035950
OpenAlexW2934202128

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.