Evidence map›Paper›PMID 30953907›Full record

ArticleBiomaterials2019

Polymeric perfluorocarbon nanoemulsions are ultrasound-activated wireless drug infusion catheters.

Q Zhong, B C Yoon, M Aryal, J B Wang, T Ilovitsh, M A Baikoghli, N Hosseini-Nassab, A Karthik, R H Cheng, K W Ferrara and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomaterials, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Article
  2. Review
  3. Remotely controlled drug release in deep brain regions of non-human primates.Journal of controlled release : official journal of the Controlled Release Society · 2024
    Article
  4. Article
  5. Article
  6. Acoustomechanically activatable liposomes for ultrasonic drug uncaging.bioRxiv : the preprint server for biology · 2023
    Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Review
  12. Review
  13. Article
  14. Ultrasound-responsive polymer-based drug delivery systems.Drug delivery and translational research · 2021
    Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Q ZhongDepartment of Radiology, Stanford University, Stanford, CA 94305, USA; David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, USA.
B C YoonDepartment of Radiology, Stanford University, Stanford, CA 94305, USA; Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA.
M AryalDepartment of Radiology, Stanford University, Stanford, CA 94305, USA.
J B WangDepartment of Radiology, Stanford University, Stanford, CA 94305, USA.
T IlovitshDepartment of Radiology, Stanford University, Stanford, CA 94305, USA; Department of Biomedical Engineering, University of California, Davis, CA 95616, USA.
M A BaikoghliDepartment of Molecular and Cellular Biology, University of California, Davis, CA 95616, USA.
N Hosseini-NassabDepartment of Radiology, Stanford University, Stanford, CA 94305, USA.
A KarthikDepartment of Radiology, Stanford University, Stanford, CA 94305, USA.
R H ChengDepartment of Molecular and Cellular Biology, University of California, Davis, CA 95616, USA.
K W FerraraDepartment of Radiology, Stanford University, Stanford, CA 94305, USA; Department of Biomedical Engineering, University of California, Davis, CA 95616, USA.
R D AiranDepartment of Radiology, Stanford University, Stanford, CA 94305, USA. Electronic address: rairan@stanford.edu.

Funding

Nano Characterization and Nano Fabrication CoreU54CA199075 · NCI · STANFORD UNIVERSITY · PI SINCLAIR, ROBERT · 2015 to 2019
$9.6M
STANFORD CANCER IMAGING TRAINING (SCIT) PROGRAMT32CA009695 · NCI · STANFORD UNIVERSITY · PI BRUCE L DANIEL, Jeremy Dahl · 1993 to 2026
$7.7M
Specific and high-resolution ultrasound cancer imagingR01CA112356 · NCI · UNIVERSITY OF CALIFORNIA DAVIS · PI FERRARA, KATHERINE W, FOIRET, JOSQUIN · 2005 to 2022
$6.1M
Image-guided ultrasound therapy and drug delivery in pancreatic cancerR01CA210553 · NCI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI FERRARA, KATHERINE W · 2016 to 2020
$3.2M
Noninvasive neuromodulation via focused ultrasonic drug uncagingRF1MH114252 · NIMH · STANFORD UNIVERSITY · PI AIRAN, RAAG D · 2017 to 2017
$1.6M
NCI NIH HHS R01 CA112356NCI NIH HHS R01 CA210553NCI NIH HHS T32 CA009695NCI NIH HHS U54 CA199075NIMH NIH HHS RF1 MH114252
6 · The paper itself

Abstract

Catheter-based intra-arterial drug therapies have proven effective for a range of oncologic, neurologic, and cardiovascular applications. However, these procedures are limited by their invasiveness and relatively broad drug spatial distribution. The ideal technique for local pharmacotherapy would be noninvasive and would flexibly deliver a given drug to any region of the body with high spatial and temporal precision. Combining polymeric perfluorocarbon nanoemulsions with existent clinical focused ultrasound systems could in principle meet these needs, but it has not been clear whether these nanoparticles could provide the necessary drug loading, stability, and generalizability across a range of drugs, beyond a few niche applications. Here, we develop polymeric perfluorocarbon nanoemulsions into a generalized platform for ultrasound-targeted delivery of hydrophobic drugs with high potential for clinical translation. We demonstrate that a wide variety of drugs may be effectively uncaged with ultrasound using these nanoparticles, with drug loading increasing with hydrophobicity. We also set the stage for clinical translation by delineating production protocols that are scalable and yield sterile, stable, and optimized ultrasound-activated drug-loaded nanoemulsions. Finally, we exhibit a new potential application of these nanoemulsions for local control of vascular tone. This work establishes the power of polymeric perfluorocarbon nanoemulsions as a clinically-translatable platform for efficacious, noninvasive, and localized ultrasonic drug uncaging for myriad targets in the brain and body.

Indexed as

Drug Delivery SystemsEmulsionsFluorocarbonsNanoparticlesPentanesPolymersEmulsionsFluorocarbonsPentanesperfluoropentanePolymersClinically translatableDrug delivery platformFocused ultrasoundNoninvasive ultrasonic drug uncagingSpatiotemporally controlled releaseTargeted drug delivery

Identifiers

PMID30953907
PMCPMC6486876

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.