Evidence map›Paper›PMID 30953870›Full record

ReviewCurrent opinion in neurobiology2019

Neuronal diversity in the somatosensory system: bridging the gap between cell type and function.

Graziana Gatto, Kelly Megan Smith, Sarah Elizabeth Ross, Martyn Goulding

Open access · greenAbstract readReview
In one paragraph

Review in Current opinion in neurobiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
6.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 74 citations in OpenAlex.

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  17. Cutaneous innervation in impaired diabetic wound healing.Translational research : the journal of laboratory and clinical medicine · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Graziana GattoMolecular Neurobiology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Rd, La Jolla, CA 92037, USA.
Kelly Megan SmithDepartment of Neurobiology and the Pittsburgh Center for Pain Research, University of Pittsburgh, 200 Lothrop St, Pittsburgh, PA 15213, USA.
Sarah Elizabeth RossDepartment of Neurobiology and the Pittsburgh Center for Pain Research, University of Pittsburgh, 200 Lothrop St, Pittsburgh, PA 15213, USA. Electronic address: saross@pitt.edu.
Martyn GouldingMolecular Neurobiology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Rd, La Jolla, CA 92037, USA. Electronic address: goulding@salk.edu.
Salk Institute for Biological Studies · USUniversity of Pittsburgh · US

Funding

Investigating the Neural Circuits of ItchR01AR063772 · NIAMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI H Richard Koerber, Sarah Elizabeth Ross · 2013 to 2026
$6.9M
Molecular genetic dissection of the spinal microcircuits of wind-upR01NS096705 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KOERBER, H RICHARD, ROSS, SARAH ELIZABETH · 2016 to 2025
$5.1M
Intersectional genetic dissection of spinal circuits processing pain and itchR01NS086372 · NINDS · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI GOULDING, MARTYN D, MA, QIUFU · 2013 to 2017
$3.5M
Spinal circuits for mechanical itch and light touchR01NS080586 · NINDS · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI GOULDING, MARTYN D · 2013 to 2018
$2.8M
NIAMS NIH HHS R01 AR063772NINDS NIH HHS R01 NS080586NINDS NIH HHS R01 NS086372NINDS NIH HHS R01 NS096705
6 · The paper itself

Abstract

A recent flurry of genetic studies in mice have provided key insights into how the somatosensory system is organized at a cellular level to encode itch, pain, temperature, and touch. These studies are largely predicated on the idea that functional cell types can be identified by their unique developmental provenance and gene expression profile. However, the extent to which gene expression profiles can be correlated with functional cell types and circuit organization remains an open question. In this review, we focus on recent progress in characterizing the sensory afferent and dorsal horn neuron cell types that process cutaneous somatosensory information and ongoing circuit studies that are beginning to bridge the divide between cell type and function.

Indexed as

NeuronsAnimalsPainPruritusTouch

Identifiers

PMID30953870
PMCPMC6583900
OpenAlexW2935076193

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.