Trial reportNeuroImage2019
Receptor-Enriched Analysis of functional connectivity by targets (REACT): A novel, multimodal analytical approach informed by PET to study the pharmacodynamic response of the brain under MDMA.
Trial report in NeuroImage, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 75 citations in OpenAlex.
- Modulation of functional networks related to the serotonin neurotransmitter system by citalopram: Evidence from a multimodal neuroimaging study.Journal of psychopharmacology (Oxford, England) · 2023Trial
- Spatial Collinearity Constrains Multivariate Molecular-Enriched Network Estimation.Human brain mapping · 2026Article
- Investigating the Contribution of Molecular-Enriched Functional Connectivity to Brain-Age Analysis.Human brain mapping · 2026Article
- Subjective and neurocognitive profiling of clinical doses of 3,4-methylenedioxymethamphetamine (MDMA) in healthy volunteers: implications for therapeutic use.Molecular psychiatry · 2026Review
- Arousal shapes motivation: an integrative framework for understanding motivational deficits.Translational psychiatry · 2026Review
- Linking human brain functional connectivity to underlying neurotransmission.bioRxiv : the preprint server for biology · 2026Article
- Exercise-Induced modulation of molecular-enriched functional connectivity in Parkinson's disease.Journal of Parkinson's disease · 2026Article
- Pharmacological MRI: Utility in Understanding Drug Mechanisms in Psychiatric Disorders.Journal of magnetic resonance imaging : JMRI · 2026Review
- Atogepant modulates brain connectivity in episodic migraine: a longitudinal exploratory fMRI study.Frontiers in neurology · 2026Article
- Knocking at the Doors of Perception: Relating LSD Effects on Low‐Frequency Fluctuations and Regional Homogeneity to Receptor Densities in fMRI.The European journal of neuroscience · 2025Article
- Investigating the Contribution of Molecular-Enriched Functional Connectivity to Brain-Age Analysis.bioRxiv : the preprint server for biology · 2025Article
- Mapping cross-modal functional connectivity of major neurotransmitter systems in the human brain.Brain structure & function · 2025Article
- Molecular-Informed Network Analysis Unveils Fatigue-Related Functional Connectivity in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2025Observational
- The neuroreceptors and transporters underlying spontaneous brain activity.Communications biology · 2025Article
- Article
- Changes in neurotransmitter-related functional connectivity along the Alzheimer's disease continuum.Brain communications · 2025Article
- Neuroimaging Biomarkers in Addiction.medRxiv : the preprint server for health sciences · 2024Article
- Normative modelling of molecular-based functional circuits captures clinical heterogeneity transdiagnostically in psychiatric patients.Communications biology · 2024Article
- Towards a biologically annotated brain connectome.Nature reviews. Neuroscience · 2023Review
- The functional connectome of 3,4-methyldioxymethamphetamine-related declarative memory impairments.Human brain mapping · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
One of the main limitations of pharmacological fMRI is its inability to provide a molecular insight into the main effect of compounds, leaving an open question about the relationship between drug effects and haemodynamic response. The aim of this study is to investigate the acute effects of 3,4-methylenedioxymethamphetamine (MDMA) on functional connectivity (FC) using a novel multimodal method (Receptor-Enriched Analysis of functional Connectivity by Targets - REACT). This approach enriches the resting state (rs-)fMRI analysis with the molecular information about the distribution density of serotonin receptors in the brain, given the serotonergic action of MDMA. Twenty healthy subjects participated in this double-blind, placebo-controlled, crossover study. A high-resolution in vivo atlas of four serotonin receptors (5-HT
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.