ArticleNeuroImage2019
Distinct patterns of default mode and executive control network circuitry contribute to present and future executive function in older adults.
Article in NeuroImage, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Meta-analytic clustering dissociates brain activity and behavior profiles across reward processing paradigms.Cognitive, affective & behavioral neuroscience · 2020Pooled it
- Altered Driving Structures and Controllability Patterns of Brain Effective Networks in Mild Cognitive Impairment and Alzheimer's Disease.Brain sciences · 2026Article
- Brain Structure-Function Association as a Compensatory Factor in Cognitive Aging.bioRxiv : the preprint server for biology · 2026Article
- A Precision Computational Framework for sLORETA Neurofeedback in Mild Cognitive Impairment: Integration of qEEG Biomarkers and Neuropsychological Metrics.International journal of environmental research and public health · 2026Article
- Longitudinal Changes in Infant Attention-Related Brain Networks and Fearful Temperament.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Functional connectivity between the caudate nucleus and the frontal lobe and its association with executive functions in children and adolescents: a resting state fMRI study.Brain imaging and behavior · 2026Article
- Similar minds age alike: an MRI similarity approach for predicting age-related cognitive decline.npj aging · 2026Article
- Changes in the cortical GABAergic inhibitory system with ageing and ageing-related neurodegenerative diseases.The Journal of physiology · 2026Review
- Disrupted Structure-Function Integration in Systemic Lupus Erythematosus and Its Impact on Cognitive Flexibility.Human brain mapping · 2025Article
- Dual-Site Beta tACS Over the rIFG and preSMA-Induced Phase-Specific Changes in Functional Connectivity but not Response Inhibition Performance in Older Adults.Psychophysiology · 2025Article
- Age and gender-related patterns of arterial transit time and cerebral blood flow in healthy adults.NeuroImage · 2025Article
- Uncovering narrative aging: an underlying neural mechanism compensated through spatial constructional ability.Communications biology · 2025Article
- Default mode network shows distinct emotional and contextual responses yet common effects of retrieval demands across tasks.Human brain mapping · 2024Article
- Article
- White matter hyperintensities influence distal cortical β-amyloid accumulation in default mode network pathways.Brain and behavior · 2023Article
- Predicting executive functioning from functional brain connectivity: network specificity and age effects.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Inflammation Disrupts the Brain Network of Executive Function after Cardiac Surgery.Annals of surgery · 2023Article
- Decreased GABA levels of the anterior and posterior cingulate cortex are associated with executive dysfunction in mild cognitive impairment.Frontiers in neuroscience · 2023Article
- EEG-Based Mapping of Resting-State Functional Brain Networks in Patients with Parkinson's Disease.Biomimetics (Basel, Switzerland) · 2022Article
- Superficial white matter microstructure affects processing speed in cerebral small vessel disease.Human brain mapping · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Executive function (EF) performance in older adults has been linked with functional and structural profiles within the executive control network (ECN) and default mode network (DMN), white matter hyperintensities (WMH) burden and levels of Alzheimer's disease (AD) pathology. Here, we simultaneously explored the unique contributions of these factors to baseline and longitudinal EF performance in older adults. Thirty-two cognitively normal (CN) older adults underwent neuropsychological testing at baseline and annually for three years. Neuroimaging and AD pathology measures were collected at baseline. Separate linear regression models were used to determine which of these variables predicted composite EF scores at baseline and/or average annual change in composite ΔEF scores over the three-year follow-up period. Results demonstrated that low DMN deactivation, high ECN activation and WMH burden were the main predictors of EF scores at baseline. In contrast, poor DMN and ECN WM microstructure and higher AD pathology predicted greater annual decline in EF scores. Subsequent mediation analysis demonstrated that DMN WM microstructure uniquely mediated the relationship between AD pathology and ΔEF. These results suggest that functional activation patterns within the DMN and ECN and WMHs contribute to baseline EF while structural connectivity within these networks impact longitudinal EF performance in older adults.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.