Evidence map›Paper›PMID 30953760›Full record

ArticleNeurobiology of disease2019

Heritability and genetic variance of dementia with Lewy bodies.

Rita Guerreiro, Valentina Escott-Price, Dena G Hernandez, Celia Kun-Rodrigues, Owen A Ross, Tatiana Orme, Joao Luis Neto, Susana Carmona, Nadia Dehghani, John D Eicher and 61 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of disease, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 44 citations in OpenAlex.

  1. Article
  2. Intrinsic capacity in Lewy body dementia: a review.The Journal of frailty & aging · 2025
    Review
  3. Review
  4. Article
  5. Article
  6. NeuroBooster Array: A Genome-Wide Genotyping Platform to Study Neurological Disorders Across Diverse Populations.Movement disorders : official journal of the Movement Disorder Society · 2024
    Article
  7. Article
  8. Review
  9. Applications of artificial intelligence in dementia research.Cambridge prisms. Precision medicine · 2023
    Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

71 authors at 20 institutions in 11 countries.

Rita GuerreiroDepartment of Neurodegenerative Diseases, UCL Institute of Neurology, London, UK; UK Dementia Research Institute (UK DRI) at UCL, London, UK.
Valentina Escott-PriceUK Dementia Research Institute (UK DRI) at Cardiff, MRC Centre for Neuropsychiatric Genetics and Genomics, School of Medicine, Cardiff University, Cardiff, UK.
Dena G HernandezLaboratory of Neurogenetics, National Institutes on Aging, NIH, Bethesda, MD, USA; German Center for Neurodegenerative Diseases (DZNE)-Tubingen, Germany.
Celia Kun-RodriguesDepartment of Neurodegenerative Diseases, UCL Institute of Neurology, London, UK.
Owen A RossDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
Tatiana OrmeDepartment of Neurodegenerative Diseases, UCL Institute of Neurology, London, UK; UK Dementia Research Institute (UK DRI) at UCL, London, UK.
Joao Luis NetoDepartment of Neurodegenerative Diseases, UCL Institute of Neurology, London, UK; UK Dementia Research Institute (UK DRI) at UCL, London, UK.
Susana CarmonaDepartment of Neurodegenerative Diseases, UCL Institute of Neurology, London, UK; UK Dementia Research Institute (UK DRI) at UCL, London, UK.
Nadia DehghaniDepartment of Neurodegenerative Diseases, UCL Institute of Neurology, London, UK; UK Dementia Research Institute (UK DRI) at UCL, London, UK.
John D EicherGenetics and Pharmacogenomics, Merck Research Laboratories, Boston, MA, USA.
Claire ShepherdNeuroscience Research Australia, Sydney, Australia and School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, Australia.
Laura ParkkinenNuffield Department of Clinical Neurosciences, Oxford Parkinsons Disease Centre, University of Oxford, Oxford, UK.
Lee DarwentUK Dementia Research Institute (UK DRI) at UCL, London, UK.
Michael G HeckmanDivision of Biomedical Statistics and Informatics, Mayo Clinic, Jacksonville, FL, USA.
Sonja W ScholzNeurodegenerative Diseases Research Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA; Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Juan C TroncosoDepartment of Pathology (Neuropathology), Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Olga PletnikovaDepartment of Pathology (Neuropathology), Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Ted DawsonDepartment of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Liana RosenthalDepartment of Neurology, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Olaf AnsorgeNuffield Department of Clinical Neurosciences, Oxford Parkinsons Disease Centre, University of Oxford, Oxford, UK.
Jordi ClarimonMemory Unit, Department of Neurology, IIB Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain.
Alberto LleoMemory Unit, Department of Neurology, IIB Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain.
Estrella Morenas-RodriguezMemory Unit, Department of Neurology, IIB Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain; Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain.
Lorraine ClarkTaub Institute for Alzheimer Disease and the Aging Brain, Department of Pathology and Cell Biology, Columbia University, New York, NY, USA.
Lawrence S HonigTaub Institute for Alzheimer Disease and the Aging Brain, Department of Pathology and Cell Biology, Columbia University, New York, NY, USA.
Karen MarderTaub Institute for Alzheimer Disease and the Aging Brain, Department of Pathology and Cell Biology, Columbia University, New York, NY, USA.
Afina LemstraDepartment of Neurology and Alzheimer Center, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, the Netherlands.
Ekaterina RogaevaTanz Centre for Research in Neurodegenerative Diseases and department of Medicine, University of Toronto, Ontario, Canada.
Peter St George-HyslopTanz Centre for Research in Neurodegenerative Diseases and department of Medicine, University of Toronto, Ontario, Canada; Department of Clinical Neurosciences, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK.
Elisabet LondosClinical Memory Research Unit, Institution of Clinical Sciences Malmo, Lund University, Sweden.
Henrik ZetterbergUK Dementia Research Institute at UCL, London UK, Department of Neurodegenerative Diseases, UCL Institute of Neurology, London, UK, Clinical Neurochemistry Laboratory, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Molndal, Sweden.
Imelda BarberHuman Genetics, School of Life Sciences, Queens Medical Centre, University of Nottingham, Nottingham, UK.
Anne BraaeHuman Genetics, School of Life Sciences, Queens Medical Centre, University of Nottingham, Nottingham, UK.
Kristelle BrownHuman Genetics, School of Life Sciences, Queens Medical Centre, University of Nottingham, Nottingham, UK.
Kevin MorganHuman Genetics, School of Life Sciences, Queens Medical Centre, University of Nottingham, Nottingham, UK.
Claire TroakesDepartment of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, Kings College London, London, UK.
Safa Al-SarrajDepartment of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, Kings College London, London, UK.
Tammaryn LashleyQueen Square Brain Bank, Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK.
Janice HoltonQueen Square Brain Bank, Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK.
Yaroslau ComptaQueen Square Brain Bank, Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK; Queen Square Brain Bank, Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK, Movement Disorders Unit, Neurology Service, Clinical Neuroscience Institute (ICN), Hospital Clinic, University of Barcelona, IDIBAPS, Barcelona, Catalonia, Spain.
Vivianna Van DeerlinDepartment of Pathology and Laboratory Medicine, Center for Neurodegenerative Disease Research, Perelman School of Medicine at the University of Pennsylvania, 3600 Spruce Street, Philadelphia, USA.
Geidy E SerranoBanner Sun Health Research Institute, 10515 W Santa Fe Drive, Sun City, AZ 85351, USA.
Thomas G BeachBanner Sun Health Research Institute, 10515 W Santa Fe Drive, Sun City, AZ 85351, USA.
Suzanne LesageInserm U1127, CNRS UMR7225, Sorbonne Universites, UPMC Univ Paris 06, UMR and S1127, Institut du Cerveau et de la Moelle epiniere, Paris, France.
Douglas GalaskoDepartment of Neurosciences, University of California, San Diego, La Jolla, CA, United States, Veterans Affairs San Diego Healthcare System, La Jolla, CA, United States.
Eliezer MasliahDepartment of Neurosciences, University of California, San Diego, La Jolla, CA, United States, Department of Pathology, University of California, San Diego, La Jolla, CA, United States.
Isabel SantanaNeurology Department, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal; Faculty of Medicine and Centre for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal.
Pau PastorMemory Unit, Department of Neurology,University Hospital Mutua de Terrassa, University of Barcelona, Fundacion de Docencia I Recerca Mutua de Terrassa, Terrassa, Barcelona, Spain. Centro de Investigacion Biomedica en Red Enfermedades Neurdegenerativas (CIBERNED), Madrid, Spain.
Monica Diez-FairenMemory Unit, Department of Neurology,University Hospital Mutua de Terrassa, University of Barcelona, Fundacion de Docencia I Recerca Mutua de Terrassa, Terrassa, Barcelona, Spain. Centro de Investigacion Biomedica en Red Enfermedades Neurdegenerativas (CIBERNED), Madrid, Spain.
Miquel AguilarMemory Unit, Department of Neurology,University Hospital Mutua de Terrassa, University of Barcelona, Fundacion de Docencia I Recerca Mutua de Terrassa, Terrassa, Barcelona, Spain. Centro de Investigacion Biomedica en Red Enfermedades Neurdegenerativas (CIBERNED), Madrid, Spain.
Pentti J TienariMolecular Neurology, Research Programs Unit, University of Helsinki, Department of Neurology, Helsinki University Hospital, Helsinki, Finland.
Liisa MyllykangasDepartment of Pathology, University of Helsinki, Helsinki University Hospital, Helsinki, Finland.
Minna OinasDepartment of Neuropathology and Neurosurgery, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
Tamas ReveszQueen Square Brain Bank, Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK.
Andrew LeesQueen Square Brain Bank, Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK.
Brad F BoeveNeurology Department, Mayo Clinic, Rochester, MN, USA.
Ronald C PetersenNeurology Department, Mayo Clinic, Rochester, MN, USA.
Tanis J FermanDepartment of Psychiatry and Department of Psychology, Mayo Clinic, Jacksonville, FL, USA.
Neill Graff-RadfordDepartment of Neurology, Mayo Clinic, Jacksonville, FL, USA.
Nigel J CairnsKnight Alzheimers Disease Research Center, Department of Neurology, Washington University School of Medicine, Saint Louis, MO, USA.
John C MorrisKnight Alzheimers Disease Research Center, Department of Neurology, Washington University School of Medicine, Saint Louis, MO, USA.
Stuart Pickering-BrownInstitute of Brain, Behaviour and Mental Health, Faculty of Medical and Human Sciences, University of Manchester, Manchester, UK.
David MannInstitute of Brain, Behaviour and Mental Health, Faculty of Medical and Human Sciences, University of Manchester, Manchester, UK.
Glenda M HallidayNeuroscience Research Australia, Sydney, Australia and School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, Australia; Brain and Mind Centre, Sydney Medical School, The University of Sydney, Sydney, Australia.
John HardyDepartment of Neurodegenerative Diseases, UCL Institute of Neurology, London, UK.
John Q TrojanowskiDepartment of Pathology and Laboratory Medicine, Center for Neurodegenerative Disease Research, Perelman School of Medicine at the University of Pennsylvania, 3600 Spruce Street, Philadelphia, USA.
Dennis W DicksonDepartment of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.
Andrew SingletonLaboratory of Neurogenetics, National Institutes on Aging, NIH, Bethesda, MD, USA.
International Parkinson's Disease Genomics Consortium
David J StoneGenetics and Pharmacogenomics, Merck Research Laboratories, West Point, PA, USA.
Jose BrasDepartment of Neurodegenerative Diseases, UCL Institute of Neurology, London, UK; UK Dementia Research Institute (UK DRI) at UCL, London, UK. Electronic address: j.bras@ucl.ac.uk.
UK Dementia Research Institute · GBOccupational Cancer Research Centre · CAJohns Hopkins University · USNational Hospital for Neurology and Neurosurgery · GBUniversity of Nottingham · GBColumbia University · USUniversitat Autònoma de Barcelona · ESUniversity Hospital Mútua de Terrassa · ESUniversity of Helsinki · FIJacksonville College · USJohn Radcliffe Hospital · GBKing's College London · GBMerck & Co., Inc., Rahway, NJ, USA (United States) · USUniversity of Manchester · GBUniversity of Pennsylvania · USUniversity of Toronto · CAWinnMed · USAmsterdam Neuroscience · NLCentre National de la Recherche Scientifique · FRGerman Center for Neurodegenerative Diseases · DE

Funding

National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)U24AG021886 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI TATIANA M. FOROUD · 2002 to 2026
$119.8M
NATIONAL ALZHEIMERS COORDINATING CENTER (NACC)U01AG016976 · NIA · UNIVERSITY OF WASHINGTON · PI KUKULL, WALTER ANTHONY · 1999 to 2020
$72.8M
Smartphone-Based "Burst" Cognitive AssessmentsP01AG003991 · NIA · WASHINGTON UNIVERSITY · PI Tammie Lee Smith Benzinger · 1985 to 2026
$69.5M
Alzheimer's Disease Genetics ConsortiumU01AG032984 · NIA · UNIVERSITY OF PENNSYLVANIA · PI SCHELLENBERG, GERARD DAVID · 2009 to 2024
$60.4M
VIRUS-INDUCED BRAIN PATHOLOGYP50AG005131 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BREWER, JAMES B · 1985 to 2018
$55.4M
WASHINGTON UNIVERSITY ALZHEIMERS DISEASE RESEARCH CENTERP50AG005681 · NIA · WASHINGTON UNIVERSITY · PI MORRIS, JOHN · 1985 to 2019
$52.1M
SUPPLEMENT TO ALZHEIMERS DISEASE PATIENT REGISTRYU01AG006786 · NIA · MAYO CLINIC ROCHESTER · PI GRAFF-RADFORD, JONATHAN, JACK, CLIFFORD R. · 1986 to 2023
$49.6M
Satellite Diagnostic and Treatment Clinic CoreP50AG008702 · NIA · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI DE JAGER, PHILIP L · 1989 to 2019
$46.3M
Understanding Mechanisms of a-synuclein pathologyP50NS038377 · NINDS · JOHNS HOPKINS UNIVERSITY · PI KO, HANSEOK · 1998 to 2019
$38.8M
'T V ASSESSMENT - MEMORY DISORDERED PATIENTS'P50AG005146 · NIA · JOHNS HOPKINS UNIVERSITY · PI HUGANIR, RICHARD L · 1985 to 2019
$37.6M
THE PGRN/TDP-43 AXIS IN ALZHEIMER?S DISEASE AND NEURODEGENERATIONP50AG016574 · NIA · MAYO CLINIC ROCHESTER · PI BU, GUOJUN · 1999 to 2018
$36.9M
UPenn ADCC Biomarker CoreP30AG010124 · NIA · UNIVERSITY OF PENNSYLVANIA · PI XIE, SHARON XIANGWEN · 1991 to 2020
$35.1M
FIC NIH HHS R03 TW008019Intramural NIH HHS Z01 AG000949Intramural NIH HHS Z01 AG000951Intramural NIH HHS Z01 ES101986Intramural NIH HHS ZIA AG000951Intramural NIH HHS ZIA NS003154Medical Research Council G0400074Medical Research Council G0502157Medical Research Council G0700943Medical Research Council G0701075Medical Research Council G0900652Medical Research Council G0901254Medical Research Council G1001253Medical Research Council G1001799Medical Research Council G1100540Medical Research Council MR/J004758/1Medical Research Council MR/K01417X/1Medical Research Council MR/L010305/1Medical Research Council MR/L016397/1Medical Research Council MR/L022656/1Medical Research Council MR/L023784/2Medical Research Council MR/L501542/1Medical Research Council MR/N026004/1NCATS NIH HHS UL1 TR000040NCI NIH HHS P01 CA089392NCI NIH HHS P50 CA084724NCI NIH HHS R01 CA141668NHGRI NIH HHS HHSN268200782096CNHGRI NIH HHS U01 HG004446NHLBI NIH HHS R01 HL105756NIA NIH HHS P01 AG003991NIA NIH HHS P01 AG004953NIA NIH HHS P01 AG014248NIA NIH HHS P30 AG010124NIA NIH HHS P30 AG062429NIA NIH HHS P50 AG005131NIA NIH HHS P50 AG005146NIA NIH HHS P50 AG005681NIA NIH HHS P50 AG008702NIA NIH HHS P50 AG016574NIA NIH HHS R01 AG033193NIA NIH HHS R01 AG048349NIA NIH HHS U01 AG006786NIA NIH HHS U01 AG016976NIA NIH HHS U01 AG032984NIA NIH HHS U24 AG021886NIDA NIH HHS P50 DA019706NINDS NIH HHS P50 NS038370NINDS NIH HHS P50 NS038377NINDS NIH HHS P50 NS053488NINDS NIH HHS P50 NS071674NINDS NIH HHS P50 NS072187NINDS NIH HHS R01 NS037167NINDS NIH HHS R01 NS060113NINDS NIH HHS R01 NS078086NINDS NIH HHS U01 NS100600NINDS NIH HHS U54 NS110435Parkinson's UK G-1307Parkinson's UK J-0804Parkinson's UK J-0901Wellcome Trust
6 · The paper itself

Abstract

Recent large-scale genetic studies have allowed for the first glimpse of the effects of common genetic variability in dementia with Lewy bodies (DLB), identifying risk variants with appreciable effect sizes. However, it is currently well established that a substantial portion of the genetic heritable component of complex traits is not captured by genome-wide significant SNPs. To overcome this issue, we have estimated the proportion of phenotypic variance explained by genetic variability (SNP heritability) in DLB using a method that is unbiased by allele frequency or linkage disequilibrium properties of the underlying variants. This shows that the heritability of DLB is nearly twice as high as previous estimates based on common variants only (31% vs 59.9%). We also determine the amount of phenotypic variance in DLB that can be explained by recent polygenic risk scores from either Parkinson's disease (PD) or Alzheimer's disease (AD), and show that, despite being highly significant, they explain a low amount of variance. Additionally, to identify pleiotropic events that might improve our understanding of the disease, we performed genetic correlation analyses of DLB with over 200 diseases and biomedically relevant traits. Our data shows that DLB has a positive correlation with education phenotypes, which is opposite to what occurs in AD. Overall, our data suggests that novel genetic risk factors for DLB should be identified by larger GWAS and these are likely to be independent from known AD and PD risk variants.

Indexed as

Genetic Predisposition to DiseaseGenetic VariationDatabases, GeneticHumansLewy Body DiseaseDementiaGenetic correlationGenetic varianceLewy bodies

Identifiers

PMID30953760
PMCPMC6588425
OpenAlexW2950081290

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.