Evidence map›Paper›PMID 30953684›Full record

ArticleReproductive toxicology (Elmsford, N.Y.)2019

Impact of prenatal arsenate exposure on gene expression in a pure population of migratory cranial neural crest cells.

Partha Mukhopadhyay, Ratnam S Seelan, Robert M Greene, M Michele Pisano

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Reproductive toxicology (Elmsford, N.Y.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Partha MukhopadhyayDepartment of Oral Immunology and Infectious Diseases, Division of Craniofacial Development and Anomalies, ULSD, University of Louisville, Louisville, KY 40202, United States.
Ratnam S SeelanDepartment of Oral Immunology and Infectious Diseases, Division of Craniofacial Development and Anomalies, ULSD, University of Louisville, Louisville, KY 40202, United States.
Robert M GreeneDepartment of Oral Immunology and Infectious Diseases, Division of Craniofacial Development and Anomalies, ULSD, University of Louisville, Louisville, KY 40202, United States. Electronic address: dr.bob.greene@gmail.com.
M Michele PisanoDepartment of Oral Immunology and Infectious Diseases, Division of Craniofacial Development and Anomalies, ULSD, University of Louisville, Louisville, KY 40202, United States.
University of Louisville · US

Funding

U-SHAPED DEVELOPMENT IN INFANT COGNITION AND PERCEPTIONP20RR017702 · NCRR · UNIVERSITY OF LOUISVILLE · PI PISANO, M. MICHELE · 2002 to 2011
$15.0M
Molecular Determinants of Developmental DefectsP20GM103453 · NIGMS · UNIVERSITY OF LOUISVILLE · PI GREENE, ROBERT M · 2012 to 2012
$1.7M
Transcriptional Coactivators and Pregnancy OutcomesR01HD053509 · NICHD · UNIVERSITY OF LOUISVILLE · PI GREENE, ROBERT M · 2008 to 2012
$1.5M
NUTRITIONAL EPIGENETICS AND OROFACIAL DEVELOPMENTR01DE018215 · NIDCR · UNIVERSITY OF LOUISVILLE · PI GREENE, ROBERT M · 2008 to 2011
$1.3M
NCRR NIH HHS P20 RR017702NICHD NIH HHS R01 HD053509NIDCR NIH HHS R01 DE018215NIGMS NIH HHS P20 GM103453
6 · The paper itself

Abstract

Prenatal exposure to arsenic, a naturally occurring toxic element, causes neural tube defects (NTDs) and, in animal models, orofacial anomalies. Since aberrant development or migration of cranial neural crest cells (CNCCs) can also cause similar anomalies within developing embryos, we examined the effects of in utero exposure to sodium arsenate on gene expression patterns in pure populations of CNCCs, isolated by fluorescence activated cell sorting (FACS), from Cre/LoxP reporter mice. Changes in gene expression were analyzed using Affymetrix GeneChip

Indexed as

Maternal-Fetal ExchangeAnimalsArsenatesEmbryo, MammalianFemaleGene Expression Regulation, DevelopmentalMice, TransgenicNeural CrestPregnancyArsenatessodium arsenateArsenateCraniofacial developmentEmbryoGene expression profilingMicroarrayNeural crest cells

Identifiers

PMID30953684
PMCPMC6545154
OpenAlexW2928581501

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.