Evidence map›Paper›PMID 30953678›Full record

ArticleNeurotoxicology2019

Do you feel it now? Route of administration and Δ

Jenny L Wiley, Timothy W Lefever, Michelle Glass, Brian F Thomas

Abstract readComparative Study
In one paragraph

Article in Neurotoxicology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. ΔDrug and alcohol dependence reports · 2023
    Article
  7. ΔCardiovascular toxicology · 2023
    Article
  8. Article
  9. Article
  10. The chemistry and toxicology of vaping.Pharmacology & therapeutics · 2021
    Review
  11. ΔDrug and alcohol dependence · 2021
    Article
  12. Sex, species and age: Effects of rodent demographics on the pharmacology of ∆Progress in neuro-psychopharmacology & biological psychiatry · 2021
    Article
  13. Article
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jenny L WileyRTI International, 3040 E. Cornwallis Road, Research Triangle Park, 27709, NC, USA. Electronic address: jwiley@rti.org.
Timothy W LefeverRTI International, 3040 E. Cornwallis Road, Research Triangle Park, 27709, NC, USA.
Michelle GlassUniversity of Otago, Department of Pharmacology and Toxicology, Dunedin, New Zealand.
Brian F ThomasRTI International, 3040 E. Cornwallis Road, Research Triangle Park, 27709, NC, USA.

Funding

THC RECEPTORSR01DA003672 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI WILEY, JENNY L. · 1985 to 2018
$4.9M
Investigation of Synthetic Cannabinoid Exposures and Pharmacological ConsequencesR01DA040460 · NIDA · RESEARCH TRIANGLE INSTITUTE · PI RANGAN MAITRA, Yanan Zhang · 2016 to 2026
$4.5M
THC RECEPTORSR37DA003672 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI MARTIN, BILLY R · 1997 to 2006
$2.8M
Comparative Pharmacology of Cannabinoids in Rodent ModelsR01DA045003 · NIDA · RESEARCH TRIANGLE INSTITUTE · PI MARUSICH, JULIE A · 2018 to 2022
$2.3M
NIDA NIH HHS R01 DA003672NIDA NIH HHS R01 DA040460NIDA NIH HHS R01 DA045003NIDA NIH HHS R37 DA003672
6 · The paper itself

Abstract

A recent push to provide more translationally relevant preclinical models for examination of pharmacological mechanisms underlying inhaled substances of abuse has resulted in the development of equipment and methods that allows exposure of freely moving rodents to aerosolized psychoactive drugs. In the present study, synthetic cannabinoids (CP55,940, AB-CHMINACA, and AMB-FUBINACA) were administered intraperitoneally (i.p.) or aerosolized via a modified electronic cigarette device. Subsequently, the compounds were evaluated in adult male and female C57/Bl6 mice trained to discriminate i.p. 5.6 mg/kg Δ

Indexed as

Electronic Nicotine Delivery SystemsVapingAdministration, InhalationAerosolsAnimalsBehavior, AnimalCannabinoidsConditioning, OperantCyclohexanolsFemaleIndazolesInjections, IntraperitonealMaleMice, Inbred C57BLValine3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanolAerosolsCannabinoidsCyclohexanolsIndazolesmethyl 2-(1-(4-fluorobenzyl)-1H-indazole-3-carboxamido)-3-methylbutanoateN-(1-(aminocarbonyl)-2-methylpropyl)-1-(cyclohexylmethyl)-1H-indazole-3-carboxamideValineDrug discriminationSynthetic cannabinoidsTetrahydrocannabinolVaping

Identifiers

PMID30953678
PMCPMC6635084

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.