ArticleSchizophrenia bulletin2019
Increased and Decreased Superficial White Matter Structural Connectivity in Schizophrenia and Bipolar Disorder.
Article in Schizophrenia bulletin, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 84 citations in OpenAlex.
- White Matter Tract Alterations in Bipolar Disorder: A Systematic Review and Meta-Analysis of Diffusion Tensor Imaging Studies.Brain and behavior · 2026Pooled it
- Widespread white matter microstructural abnormalities in bipolar disorder: evidence from mega- and meta-analyses across 3033 individuals.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Pooled it
- Schizophrenia and bipolar disorder: a comparative analysis of genetic and brain network connectivity.Psychological medicine · 2026Article
- Altered white matter integrity in pediatric bipolar disorder and the potential role of psychotic symptoms revealed by free water elimination corrected and superficial white matter DTI analyses.European child & adolescent psychiatry · 2026Article
- Superficial white matter (SWM) microstructural alterations in Parkinson's disease: a neurite orientation dispersion and density imaging and diffusion tensor imaging study.Quantitative imaging in medicine and surgery · 2026Article
- Identifying transdiagnostic neurobiomarkers for precision major psychiatric disordersJournal of translational internal medicine · 2026Article
- Mendelian randomization analysis: causal link between hyperthyroidism/thyrotoxicosis and ovarian cancer.Discover oncology · 2025Article
- Common and unique white matter fractional anisotropy patterns in patients with schizophrenia with medication-resistant auditory verbal hallucinations: a retrospective tract-based spatial statistics study.Schizophrenia (Heidelberg, Germany) · 2025Article
- Neurophysiological Markers of Auditory Verbal Hallucinations in Patients with Schizophrenia: An EEG Microstates Study.Brain topography · 2025Article
- Sensory and Multisensory Processing Changes and Their Contributions to Autism and Schizophrenia.Current topics in behavioral neurosciences · 2025Review
- Comparative analysis of the chimpanzee and human brain superficial structural connectivities.Brain structure & function · 2024Article
- Assessment of the Depiction of Superficial White Matter Using Ultra-High-Resolution Diffusion MRI.Human brain mapping · 2024Article
- Structural network disruption of corticothalamic pathways in cerebral small vessel disease.Brain imaging and behavior · 2024Article
- Neuropeptide FF (NPFF)-positive nerve cells of the human cerebral cortex and white matter in controls, selected neurodegenerative diseases, and schizophrenia.Acta neuropathologica communications · 2024Article
- Genetic architecture of the structural connectome.Nature communications · 2024Article
- Phybers: a package for brain tractography analysis.Frontiers in neuroscience · 2024Article
- Imaging of the superficial white matter in health and disease.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Enhanced Dynamic Laterality Based on Functional Subnetworks in Patients with Bipolar Disorder.Brain sciences · 2023Article
- In vivo mapping of the deep and superficial white matter connectivity in the chimpanzee brain.NeuroImage · 2023Article
- Structural impairment in superficial and deep white matter in schizophrenia.Acta neuropsychiatrica · 2023Article
Corrections and comments
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Authors and funding
14 authors at 9 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Schizophrenia (SZ) and bipolar disorder (BD) are often conceptualized as "disconnection syndromes," with substantial evidence of abnormalities in deep white matter tracts, forming the substrates of long-range connectivity, seen in both disorders. However, the study of superficial white matter (SWM) U-shaped short-range tracts remained challenging until recently, although findings from postmortem studies suggest they are likely integral components of SZ and BD neuropathology. This diffusion weighted imaging (DWI) study aimed to investigate SWM microstructure in vivo in both SZ and BD for the first time. We performed whole brain tractography in 31 people with SZ, 32 people with BD and 54 controls using BrainVISA and Connectomist 2.0. Segmentation and labeling of SWM tracts were performed using a novel, comprehensive U-fiber atlas. Analysis of covariances yielded significant generalized fractional anisotropy (gFA) differences for 17 SWM bundles in frontal, parietal, and temporal cortices. Post hoc analyses showed gFA reductions in both patient groups as compared with controls in bundles connecting regions involved in language processing, mood regulation, working memory, and motor function (pars opercularis, insula, anterior cingulate, precentral gyrus). We also found increased gFA in SZ patients in areas overlapping the default mode network (inferior parietal, middle temporal, precuneus), supporting functional hyperconnectivity of this network evidenced in SZ. We thus illustrate that short U-fibers are vulnerable to the pathological processes in major psychiatric illnesses, encouraging improved understanding of their anatomy and function.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.