Evidence map›Paper›PMID 30953480›Full record

ArticleBMC pediatrics2019

Delayed appearance of mature ganglia in an infant with an atypical presentation of total colonic and small bowel aganglionosis: a case report.

Fereshteh Salimi Jazi, Julia M Chandler, Chad M Thorson, Tiffany J Sinclair, Florette K Hazard, John A Kerner, Sanjeev Dutta, James C Y Dunn, Stephanie D Chao

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC pediatrics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Fereshteh Salimi JaziDepartment of Surgery, University of Texas at Galveston, 301 University Blvd, Galveston, TX, 77555, USA.
Julia M ChandlerDivision of Pediatric Surgery, Department of Surgery, Stanford University School of Medicine, 300 Pasteur Drive, Alway Building M116, MC: 5733, Stanford, CA, 94305, USA.
Chad M ThorsonDivision of Pediatric Surgery, Department of Surgery, University of Miami Health System, 1120 NW 14th Street, Suite 450, Miami, FL, 33136, USA.
Tiffany J SinclairDivision of Pediatric Surgery, Department of Surgery, Stanford University School of Medicine, 300 Pasteur Drive, Alway Building M116, MC: 5733, Stanford, CA, 94305, USA.
Florette K HazardDepartment of Pathology, Stanford University School of Medicine, 300 Pasteur Drive Rm H2110, Stanford, CA, 94305, USA.
John A KernerDepartment of Pediatrics - Gastroenterology, Stanford University School of Medicine, 730 Welch Rd 2nd Fl, Palo Alto, CA, 94304, USA.
Sanjeev Dutta
James C Y DunnDivision of Pediatric Surgery, Department of Surgery, Stanford University School of Medicine, 300 Pasteur Drive, Alway Building M116, MC: 5733, Stanford, CA, 94305, USA.
Stephanie D ChaoDivision of Pediatric Surgery, Department of Surgery, Stanford University School of Medicine, 300 Pasteur Drive, Alway Building M116, MC: 5733, Stanford, CA, 94305, USA. sdchao@stanford.edu.ORCID 0000-0003-0139-8551
Stanford University · USTexas A&M University at Galveston · USUniversity of Miami Health System · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTotal colonic and small bowel aganglionosis (TCSA) occurs in less than 1% of all Hirschsprung's disease patients. Currently, the mainstay of treatment is surgery. However, in patients with TCSA, functional outcomes are often poor. A characteristic transition zone in TCSA can be difficult to identify which may complicate surgery and may often require multiple operations. CASE PRESENTATION: We present the case of a male infant who was diagnosed with biopsy-proven total colonic aganglionosis with extensive small bowel involvement as a neonate. The patient was diverted at one month of age based on leveling biopsies at 10 cm from the Ligament of Treitz. At 7 months of age, during stoma revision for a prolapsed stoma, intra-operative peristalsis was observed in nearly the entire length of the previously aganglionic bowel, and subsequent biopsies demonstrated the appearance of mature ganglion cells in a previously aganglionic segment.

conclusionsTCSA remains a major challenge for pediatric surgeons. Our case introduces new controversy to our understanding of aganglionosis. Our observations warrant further research into the possibility of post-natal ganglion maturation and encourage surgeons to consider a more conservative surgical approach.

Indexed as

BiopsyColonGangliaHirschsprung DiseaseHumansInfant, NewbornIntestinal DiseasesIntestine, SmallMaleRadiographyAganglionosisHirschsprung’s diseaseTotal colonic aganglionosisTotal colonic and small bowel aganglionosis

Identifiers

PMID30953480
PMCPMC6449943
OpenAlexW4250584428

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.