Evidence map›Paper›PMID 30953478›Full record

ArticleBMC cardiovascular disorders2019

Association of sex, age and education level with patient reported outcomes in atrial fibrillation.

Kelly T Gleason, Cheryl R Dennison Himmelfarb, Daniel E Ford, Harold Lehmann, Laura Samuel, Hae Ra Han, Sandeep K Jain, Gerald V Naccarelli, Vikas Aggarwal, Saman Nazarian

Registry-linked trialAbstract readComparative StudyMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cardiovascular disorders, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02485288 (PaTH Clinical Data Research Network), which is not on this map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02485288 active not recruitingnot on this map

PaTH Clinical Data Research Network (CDRN) Atrial Fibrillation (AF) Clinician-Patient Partnership Cohort

Typeobservational_patient_registrySponsorUniversity of PittsburghRan2015 to 2030Enrolled1,500ConditionsAtrial Fibrillation
3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. The impact of screening-detected atrial fibrillation and associated outcomes on quality of life.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2025
    Trial
  3. Article
  4. Article
  5. Article
  6. Observational
  7. Article
  8. Article
  9. Article
  10. Article
  11. Sex- and age-specific differences in the use of antiarrhythmic therapies among atrial fibrillation patients: a nationwide cohort study.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2024
    Article
  12. Review
  13. Review
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  15. Article
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  17. Article
  18. Women and atrial fibrillation.Journal of cardiovascular electrophysiology · 2021
    Review
  19. Article
  20. Patient-reported outcomes and the identification of subgroups of atrial fibrillation patients: a retrospective cohort study of linked clinical registry and administrative data.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kelly T GleasonSchool of Nursing, Johns Hopkins University, 525 N Wolfe Street, Baltimore, MD, 21205, USA. kgleaso2@jhmi.edu.ORCID 0000-0002-4203-6517
Cheryl R Dennison HimmelfarbSchool of Nursing, Johns Hopkins University, 525 N Wolfe Street, Baltimore, MD, 21205, USA.
Daniel E FordSchool of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Harold LehmannSchool of Medicine, Johns Hopkins University, Baltimore, MD, USA.
Laura SamuelSchool of Nursing, Johns Hopkins University, 525 N Wolfe Street, Baltimore, MD, 21205, USA.
Hae Ra HanSchool of Nursing, Johns Hopkins University, 525 N Wolfe Street, Baltimore, MD, 21205, USA.
Sandeep K JainSchool of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Gerald V NaccarelliPenn State Milton S. Hershey Medical Center, State College, Hershey, PA, USA.
Vikas AggarwalUniversity of Michigan Health System/Frankel Cardiovascular Center, Ann Harbor, MI, USA.
Saman NazarianSchool of Medicine, Johns Hopkins University, Baltimore, MD, USA.

Funding

Household income, financial stress and physiologic aging markers in low income adults across the life courseK01AG054751 · NIA · JOHNS HOPKINS UNIVERSITY · PI SAMUEL, LAURA · 2018 to 2022
$651k
NIA NIH HHS K01 AG054751
6 · The paper itself

Abstract

backgroundIn atrial fibrillation (AF), there are known sex and sociodemographic disparities in clinical outcomes such as stroke. We investigate whether disparities also exist with respect to patient-reported outcomes. We explored the association of sex, age, and education level with patient-reported outcomes (AF-related quality of life, symptom severity, and emotional and functional status).

methodsThe PaTH AF cohort study recruited participants (N = 953) with an AF diagnosis and age ≥ 18 years across 4 academic medical centers. We performed longitudinal multiple regression with random effects to determine if individual characteristics were associated with patient-reported outcomes.

resultsWomen reported poorer functional status (β - 2.23, 95% CI: -3.52, - 0.94) and AF-related quality of life (β - 4.12, 95% CI: -8.10, - 0.14), and higher symptoms of anxiety (β 2.08, 95% CI: 0.76, 3.40), depression (β 1.44, 95% CI: 0.25, 2.63), and AF (β 0.29, 95% CI: 0.08, 0.50). Individuals < 60 years were significantly (p < 0.05) more likely to report higher symptoms of depression, anxiety, and AF, and poorer AF-related quality of life. Lack of college education was associated with reporting higher symptoms of AF (β 0.42, 95% CI: 0.17, 0.68), anxiety (β 1.86, 95% CI: 0.26, 3.45), and depression (β 1.11, 95% CI: 0.15, 2.38), and lower AF-related quality of life (β - 4.41, 95% CI: -8.25, - 0.57) and functional status.

conclusionWomen, younger adults, and individuals with lower levels of education reported comparatively poor patient-reported outcomes. These findings highlight the importance of understanding why individuals experience AF differently based on certain characteristics.

Indexed as

Educational StatusHealth Status DisparitiesPatient Reported Outcome MeasuresSocial Determinants of HealthAdolescentAdultAgedAged, 80 and overAge FactorsAtrial FibrillationEmotionsFemaleHealth StatusHumansMaleMental HealthAgeAtrial fibrillationLongitudinal cohort studyPatient-reported outcomesQuality of lifeSexSymptoms

Identifiers

PMID30953478
PMCPMC6451250

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.