Evidence map›Paper›PMID 3095335›Full record

ArticleThe Journal of cell biology1986

Talin at myotendinous junctions.

J G Tidball, T O'Halloran, K Burridge

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of cell biology, 1986. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 154 citations in OpenAlex.

  1. Article
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  4. Review
  5. Talin1 is required for cardiac Z-disk stabilization and endothelial integrity in zebrafish.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2015
    Article
  6. Morphogenesis of rat myotendinous junction.Muscles, ligaments and tendons journal · 2013
    Article
  7. Localization and function of Xinα in mouse skeletal muscle.American journal of physiology. Cell physiology · 2013
    Article
  8. The development of the myotendinous junction. A review.Muscles, ligaments and tendons journal · 2012
    Article
  9. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

J G Tidball
T O'Halloran
K Burridge
University of California, Riverside · US

Funding

STRUCTURE/FUNCTION OF FOCAL ADHESIONSR01GM029860 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BURRIDGE, KEITH · 1985 to 2018
$6.7M
NIGMS NIH HHS GM-29860
6 · The paper itself

Abstract

Junctions formed by skeletal muscles where they adhere to tendons, called myotendinous junctions, are sites of tight adhesion and where forces generated by the cell are placed on the substratum. In this regard, myotendinous junctions and focal contacts of fibroblasts in vitro are analogues. Talin is a protein located at focal contacts that may be involved in force transmission from actin filaments to the plasma membrane. This study investigates whether talin is also found at myotendinous junctions. Protein separations on SDS polyacrylamide gels and immunolabeling procedures show that talin is present in skeletal muscle. Immunofluorescence microscopy using anti-talin indicates that talin is found concentrated at myotendinous junctions and in lesser amounts in periodic bands over nonjunctional regions. Electron microscopic immunolabeling shows talin is a component of the digitlike processes of muscle cells that extend into tendons at myotendinous junctions. These findings indicate that there may be similarities in the molecular composition of focal contacts and myotendinous junctions in addition to functional analogies.

Indexed as

AnimalsChickensCytoskeletal ProteinsFluorescent Antibody TechniqueIntercellular JunctionsMusclesStress, MechanicalTalinTendonsCytoskeletal ProteinsTalin

Identifiers

PMID3095335
PMCPMC2114324
OpenAlexW1991201761

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.