ReviewDigestive diseases and sciences2019
Chronic Megacolon Presenting in Adolescents or Adults: Clinical Manifestations, Diagnosis, and Genetic Associations.
Review in Digestive diseases and sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04340856 (Retrospective, Uncontrolled Multcentric Cohort Study on the Therapy of Chronic Megalon), which is not on this map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Retrospective, Uncontrolled Multcentric Cohort Study on the Therapy of Chronic Megalon (CoMeC)
Who cites it
12 citing papers in PubMed, 22 citations in OpenAlex.
- Sigmoid volvulus, acute colonic pseudo-obstruction, and chronic megacolon in Parkinson disease.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2026Article
- National Medical Expenditures Associated With Pediatric Disorders of Gut-Brain Interaction in the United States.Neurogastroenterology and motility · 2026Article
- Familial adult-onset chronic idiopathic megacolon: diagnostic and surgical challenges-a case report.Journal of surgical case reports · 2026Article
- Forensic considerations in cases of fatal constipation.Forensic science, medicine, and pathology · 2025Review
- A Rare Case of Idiopathic Megacolon and Megarectum.Cureus · 2024Article
- Adult patients with allied disorders of Hirschsprung's disease in emergency department: An 11-year retrospective study.World journal of gastrointestinal surgery · 2022Article
- Idiopathic megabowel causing acute bowel obstruction: A case report.Annals of medicine and surgery (2012) · 2022Article
- Bowel perforation due to chronic idiopathic megacolon: Case report and literature review.International journal of surgery case reports · 2022Article
- The Classification and Surgical Treatments in Adult Hirschsprung's Disease: A Retrospective Study.Frontiers in medicine · 2022Article
- Idiopathic Megacolon-Short Review.Diagnostics (Basel, Switzerland) · 2021Review
- Characterization of gut contractility and microbiota in patients with severe chronic constipation.PloS one · 2020Article
- [Chronic Megacolon in Young Patients: Epidemiological, Clinical, and Manometric Characteristics].Acta gastroenterologica LatinoamericanaArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
objectiveChronic megacolon is rarely encountered in clinical practice beyond infancy or early childhood. Most cases are sporadic, and some are familial megacolon and present during adolescence or adulthood. There is a need for diagnostic criteria and identifying genetic variants reported in non-Hirschsprung's megacolon.
methodsPubMed search was conducted using specific key words.
resultsThis article reviews the clinical manifestations, current diagnostic criteria, and intraluminal measurements of colonic compliance to confirm the diagnosis when the radiological imaging is not conclusive. Normal ranges of colonic compliance at 20, 30, and 44 mmHg distension are provided. The diverse genetic associations with chronic acquired megacolon beyond childhood are reviewed, including the potential association of SEMA3F gene in a family with megacolon.
conclusionsMeasuring colonic compliance could be standardized and simplified by measuring volume at 20, 30, and 44 mmHg distension to identify megacolon when radiology is inconclusive. Diverse genetic associations with chronic acquired megacolon beyond childhood have been identified.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.