Evidence map›Paper›PMID 30953062›Full record

ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2020

Adherence and Viral Suppression Among Participants of the Patient-centered Human Immunodeficiency Virus (HIV) Care Model Project: A Collaboration Between Community-based Pharmacists and HIV Clinical Providers.

Kathy K Byrd, John G Hou, Tim Bush, Ron Hazen, Heather Kirkham, Ambrose Delpino, Paul J Weidle, Michael D Shankle, Nasima M Camp, Sumihiro Suzuki and 2 more

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In one paragraph

Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  20. Pharmacist-delivered HIV point-of-care testing in Ontario: Lessons learned from the GetaTest pilot.Canadian pharmacists journal : CPJ = Revue des pharmaciens du Canada : RPC · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Kathy K ByrdDivision of Human Immunodeficiency Virus (HIV)/ Acquired Immunodeficiency Syndrome (AIDS) Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia.
John G HouHealth Analytics, Research, and Reporting, Walgreen Company, Deerfield, Illinois.
Tim BushDivision of Human Immunodeficiency Virus (HIV)/ Acquired Immunodeficiency Syndrome (AIDS) Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia.
Ron HazenHealth Analytics, Research, and Reporting, Walgreen Company, Deerfield, Illinois.
Heather KirkhamHealth Analytics, Research, and Reporting, Walgreen Company, Deerfield, Illinois.
Ambrose DelpinoPatient Care and Advocacy Department, Walgreen Company, Deerfield, Illinois.
Paul J WeidleDivision of Human Immunodeficiency Virus (HIV)/ Acquired Immunodeficiency Syndrome (AIDS) Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia.
Michael D ShankleHealthHIV, Washington, District of Columbia.
Nasima M CampDepartment of Health, Research, Informatics, and Technology, ICF, Atlanta, Georgia.
Sumihiro SuzukiDepartment of Biostatistics and Epidemiology, University of North Texas Health Science Center, Fort Worth.
Patrick G ClayDepartment of Pharmacotherapy, System College of Pharmacy, University of North Texas Health Science Center, Fort Worth.
Patient-centered HIV Care Model Team

Funding

Intramural CDC HHS CC999999
6 · The paper itself

Abstract

backgroundHuman immunodeficiency virus (HIV) viral suppression (VS) decreases morbidity, mortality, and transmission risk.

methodsThe Patient-centered HIV Care Model integrated community-based pharmacists with HIV medical providers and required them to share patient clinical information, identify therapy-related problems, and develop therapy-related action plans.Proportions adherent to antiretroviral therapy (proportion of days covered [PDC] ≥90%) and virally suppressed (HIV RNA <200 copies/mL), before and after model implementation, were compared. Factors associated with postimplementation VS were determined using multivariable logistic regression; participant demographics, baseline viral load, and PDC were explanatory variables. PDC was modified to account for time to last viral load in the year postimplementation, and stratified as <50%, 50% to <80%, 80% to <90%, and ≥90%.

resultsThe 765 enrolled participants were 43% non-Hispanic black, 73% male, with a median age of 48 years; 421 and 649 were included in the adherence and VS analyses, respectively. Overall, proportions adherent to therapy remained unchanged. However, VS improved a relative 15% (75% to 86%, P < .001). Higher PDC (adjusted odds ratio [AOR], 1.74 per 1-level increase in PDC category [95% confidence interval {CI}, 1.30-2.34]) and baseline VS (AOR, 7.69 [95% CI, 3.96-15.7]) were associated with postimplementation VS. Although non-Hispanic black persons (AOR, 0.29 [95% CI, .12-.62]) had lower odds of suppression, VS improved a relative 23% (63% to 78%, P < .001).

conclusionsIntegrated care models between community-based pharmacists and primary medical providers may identify and address HIV therapy-related problems and improve VS among persons with HIV.

Indexed as

Anti-HIV AgentsHIV InfectionsFemaleHIVHumansMaleMedication AdherenceMiddle AgedPatient-Centered CarePharmacistsViral LoadAnti-HIV Agentsantiretroviral therapyHIVmedication adherencepatient-centered HIV care modelsustained virologic response

Identifiers

PMID30953062
PMCPMC6821576

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.