Evidence map›Paper›PMID 30953027›Full record

ArticleBone marrow transplantation2019

Fevers post infusion of T-cell replete hla mismatched haploidentical hematopoietic stem cells with post-transplant cyclophosphamide: risk factors and impact on transplant outcomes.

Melhem M Solh, Elizabeth Dickhaus, Scott R Solomon, Lawrence E Morris, Xu Zhang, H Kent Holland, Asad Bashey

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in Bone marrow transplantation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06828796 (Early Use of Tacrolimus in HLA-Mismatched Haploidentical Allogeneic Hematopoietic Transplantation With Post-Transplant Cyclophosphamide), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06828796 phase2recruitingnot on this mapstarted 2025, after this paper: background citation

Early Use of Tacrolimus in HLA-Mismatched Haploidentical Allogeneic Hematopoietic Transplantation With Post-Transplant Cyclophosphamide

TypeinterventionalSponsorNorthside Hospital, Inc.Ran2025 to 2028Enrolled20ConditionsHematologic Disease and Disorders, Hematopoietic Cell TransplantArmsTacrolimus, Cyclophosphamide, Mycofenolate mofetil
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

  1. Trial
  2. Observational
  3. Anti-thymocyte globulin-resistant CD4Blood science (Baltimore, Md.) · 2026
    Article
  4. Review
  5. Haploidentical Related Donor Hematopoietic Stem Cell Transplantation for Dedicator-of-Cytokinesis 8 Deficiency Using Post-Transplantation Cyclophosphamide.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Melhem M SolhBlood and Marrow Transplant Program at Northside Hospital, Atlanta, GA, USA. msolh@bmtga.com.
Elizabeth DickhausBlood and Marrow Transplant Program at Northside Hospital, Atlanta, GA, USA.
Scott R SolomonBlood and Marrow Transplant Program at Northside Hospital, Atlanta, GA, USA.
Lawrence E MorrisBlood and Marrow Transplant Program at Northside Hospital, Atlanta, GA, USA.
Xu ZhangCenter for Clinical and Translational Sciences, University of Texas Health Science Center at Houston, Houston, TX, USA.
H Kent HollandBlood and Marrow Transplant Program at Northside Hospital, Atlanta, GA, USA.
Asad BasheyBlood and Marrow Transplant Program at Northside Hospital, Atlanta, GA, USA.
Northside Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fever is a common early complication after infusion of stem cells in patients undergoing T-replete HLA haploidentical transplantation using post-transplant cyclophosphamide (PTCY). We analyzed the records of 172 haploidentical transplant patients to identify risk factors and to assess the impact of such fevers on transplant morbidity and mortality. One hundred and seventy-two patients received haploidential hematopoietic stem cell transplantation (haplo-HSCT) using PBSC (n = 103) or marrow (n = 69) grafts. One hundred and forty patients (81%) experienced fever (T ≥ 100.5 °F or >38 °C) with median onset on d + 2. Compared to patients who did not develop fevers, patients with fevers received higher median CD34+ cell dose (5.00 vs. 3.08 × 10

Indexed as

FeverLymphocyte DepletionPeripheral Blood Stem Cell TransplantationT-LymphocytesAdultAgedAllograftsFemaleHLA AntigensHumansMaleMiddle AgedRetrospective StudiesRisk FactorsHLA Antigens

Identifiers

PMID30953027
OpenAlexW2927629451

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.