ArticleThe ISME journal2019
Establishment of an induced memory response in Pseudomonas aeruginosa during infection of a eukaryotic host.
Article in The ISME journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- The insect- and plant-associated lifestyles of Pseudomonas protegens CHA0 are preserved following serial passage through insect larvae.PLoS pathogens · 2026Article
- MiaA-mediated tRNA modifications couple tryptophan attenuation and changes in tRNA abundance to complex phenotypes in Pseudomonas aeruginosa.Nucleic acids research · 2026Article
- An antibiotic-responsive regulator orchestrates chronic-to-acute virulence switch in Pseudomonas aeruginosa.Nucleic acids research · 2025Article
- Establishment and characterization of persistentInfection and immunity · 2025Article
- Environment-mediated interactions cause an externalized and collective memory in bacteria.The ISME journal · 2025Article
- AI-2 quorum sensing controlled delivery of cytolysin-A by tryptophan auxotrophic low-endotoxic Salmonella and its anticancer effects in CT26 mice with colon cancer.Journal of advanced research · 2024Article
- tRNA epitranscriptome determines pathogenicity of the opportunistic pathogenProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Bacterial Adaptive Memory in Methicillin-ResistantPathogens (Basel, Switzerland) · 2024Article
- Bacterial memory in antibiotic resistance evolution and nanotechnology in evolutionary biology.iScience · 2023Review
- How Three Self-Secreted Biofilm Exopolysaccharides ofInternational journal of molecular sciences · 2023Review
- Challenges in using transcriptome data to study the c-di-GMP signaling network inFEMS microbes · 2023Article
- Genome-Based Analysis of Virulence Factors and Biofilm Formation in NovelMicroorganisms · 2022Article
- Novel prokaryotic system employing previously unknown nucleic acids-based receptors.Microbial cell factories · 2022Article
- Targeting primary and metastatic tumor growth in an aggressive breast cancer by engineered tryptophan auxotrophicMolecular therapy oncolytics · 2022Article
- Evolution of biofilm-adapted gene expression profiles in lasR-deficient clinical Pseudomonas aeruginosa isolates.NPJ biofilms and microbiomes · 2022Article
- What Makes Pseudomonas aeruginosa a Pathogen?Advances in experimental medicine and biology · 2022Article
- Memory shapes microbial populations.PLoS computational biology · 2021Article
- Expression of the MexXY Aminoglycoside Efflux Pump and Presence of an Aminoglycoside-Modifying Enzyme in Clinical Pseudomonas aeruginosa Isolates Are Highly Correlated.Antimicrobial agents and chemotherapy · 2020Article
- Unsaturated Fatty Acids Control Biofilm Formation ofAntibiotics (Basel, Switzerland) · 2020Article
- Untargeted LC-MS Metabolomics Differentiates Between Virulent and Avirulent Clinical Strains ofBiomolecules · 2020Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In a given habitat, bacterial cells often experience recurrent exposures to the same environmental stimulus. The ability to memorize the past event and to adjust current behaviors can lead to efficient adaptation to the recurring stimulus. Here we demonstrate that the versatile bacterium Pseudomonas aeruginosa adopts a virulence phenotype after serial passage in the invertebrate model host Galleria mellonella. The virulence phenotype was not linked to the acquisition of genetic variations and was sustained for several generations, despite cultivation of the ex vivo virulence-adapted P. aeruginosa cells under rich medium conditions in vitro. Transcriptional reprogramming seemed to be induced by a host-specific food source, as reprogramming was also observed upon cultivation of P. aeruginosa in rich medium supplemented with polyunsaturated long-chain fatty acids. The establishment of induced memory responses adds a time dimension and seems to fill the gap between long-term evolutionary genotypic adaptation and short-term induced individual responses. Efforts to unravel the fundamental mechanisms that underlie the carry-over effect to induce such memory responses will continue to be of importance as hysteretic behavior can serve survival of bacterial populations in changing and challenging habitats.
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