ArticleScientific reports2019
Pseudomonas aeruginosa inhibits Rhizopus microsporus germination through sequestration of free environmental iron.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 41 citations in OpenAlex.
- Bacterial-fungal interactions: connections and consequences.Essays in biochemistry · 2026Review
- Role of Iron Availability in ModulatingJournal of fungi (Basel, Switzerland) · 2026Article
- Quantitative Estimation of Auxin, Siderophore, and Hydrogen Cyanide Production in Halo and Drought-Tolerant Bacterial Isolates for Cucumber Growth.Bio-protocol · 2025Article
- The pathobiology of human fungal infections.Nature reviews. Microbiology · 2024Review
- Prospects of iron solubilizing Bacillus species for improving growth and iron in maize (Zea mays L.) under axenic conditions.Scientific reports · 2024Article
- Exploring the dynamics of mixed-species biofilms involving Candida spp. and bacteria in cystic fibrosis.Archives of microbiology · 2024Review
- Co-Occurrence of Gram-Negative Rods in Patients with Hematologic Malignancy and Sinopulmonary Mucormycosis.Journal of fungi (Basel, Switzerland) · 2024Article
- Evaluation of Tunisian wheat endophytes as plant growth promoting bacteria and biological control agents against Fusarium culmorum.PloS one · 2024Article
- AlternativeFrontiers in cellular and infection microbiology · 2024Review
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- Diagnostic and Treatment Challenges of Emergent COVID-Associated-Mucormycosis: A Case Report and Review of the Literature.Antibiotics (Basel, Switzerland) · 2022Article
- Resistance evolution can disrupt antibiotic exposure protection through competitive exclusion of the protective species.The ISME journal · 2022Article
- Quantitative High-Throughput Screening Methods Designed for Identification of Bacterial Biocontrol Strains with Antifungal Properties.Microbiology spectrum · 2022Article
- Pseudomonas Synergizes with Fluconazole againstInfection and immunity · 2022Article
- Isolated Cerebral Mucormycosis in Immunocompetent Adults who Inject Drugs: Case Reports and Systematic Review of the Literature.Open forum infectious diseases · 2020Article
- Article
- Rhizoferrin Glycosylation inJournal of fungi (Basel, Switzerland) · 2020Article
- Review
- Review
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Rhizopus spp are the most common etiological agents of mucormycosis, causing over 90% mortality in disseminated infection. Key to pathogenesis is the ability of fungal spores to swell, germinate, and penetrate surrounding tissues. Antibiotic treatment in at-risk patients increases the probability of the patient developing mucormycosis, suggesting that bacteria have the potential to control the growth of the fungus. However, research into polymicrobial relationships involving Rhizopus spp has not been extensively explored. Here we show that co-culturing Rhizopus microsporus and Pseudomonas aeruginosa results in the inhibition of spore germination. This inhibition was mediated via the secretion of bacterial siderophores, which induced iron stress on the fungus. Addition of P. aeruginosa siderophores to R. microsporus spores in the zebrafish larval model of infection resulted in inhibition of fungal germination and reduced host mortality. Therefore, during infection antibacterial treatment may relieve bacterial imposed nutrient restriction resulting in secondary fungal infections.
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Registered trials
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