ArticleScientific reports2019
Neural correlates of abnormal auditory feedback processing during speech production in Alzheimer's disease.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- A randomised controlled trial investigating the causal role of the medial prefrontal cortex in mediating self-agency during speech monitoring and reality monitoring.Scientific reports · 2024Trial
- Altered Inter-Network Functional Integration Underlies Speech Impairment in Parkinson's Disease: A Resting-State fMRI Analysis.Brain and behavior · 2026Article
- Disorders of the Basal Ganglia and Cerebellum: A Comprehensive Review of Speech Sensorimotor Symptoms and Responses to Feedback Perturbations.Neurobiology of language (Cambridge, Mass.) · 2026Review
- Enhanced pitch centering in individuals with laryngeal dystonia.Frontiers in human neuroscience · 2026Article
- Phase-Specific Contributions and Interactions of the Left and Right Posterior Middle Temporal Gyri in Vocal Feedback Control: Evidence From Dual-Site TMS.Human brain mapping · 2025Article
- Causal role of medial superior frontal cortex on enhancing neural information flow and self-agency judgments in the self-agency network.NeuroImage · 2025Article
- Impairment of the internal forward model and feedback mechanisms for vocal sensorimotor control in post-stroke aphasia: evidence from directional responses to altered auditory feedback.Experimental brain research · 2024Article
- Pitch corrections occur in natural speech and are abnormal in patients with Alzheimer's disease.Frontiers in human neuroscience · 2024Article
- Article
- Aging-related decline in the neuromotor control of speech production: current and future.Frontiers in aging neuroscience · 2023Article
- Transcranial direct current stimulation over left dorsolateral prefrontal cortex facilitates auditory-motor integration for vocal pitch regulation.Frontiers in neuroscience · 2023Article
- The pattern of cortical thickness underlying disruptive behaviors in Alzheimer's disease.Psychoradiology · 2022Article
- Early auditory responses to speech sounds in Parkinson's disease: preliminary data.Scientific reports · 2022Article
- Temporal specificity of abnormal neural oscillations during phonatory events in laryngeal dystonia.Brain communications · 2022Article
- A Causal Role of the Cerebellum in Auditory Feedback Control of Vocal Production.Cerebellum (London, England) · 2021Article
- Processing of Degraded Speech in Brain Disorders.Brain sciences · 2021Review
- The Role of the Medial Prefontal Cortex in Self-Agency in Schizophrenia.Journal of psychiatry and brain science · 2021Article
- Neurobehavioral Effects of LSVTFrontiers in neuroscience · 2021Article
- Contribution of sensory memory to speech motor learning.Journal of neurophysiology · 2020Article
- Cerebellar contribution to auditory feedback control of speech production: Evidence from patients with spinocerebellar ataxia.Human brain mapping · 2019Article
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Authors and funding
13 authors.
Funding
Abstract
Accurate integration of sensory inputs and motor commands is essential to achieve successful behavioral goals. A robust model of sensorimotor integration is the pitch perturbation response, in which speakers respond rapidly to shifts of the pitch in their auditory feedback. In a previous study, we demonstrated abnormal sensorimotor integration in patients with Alzheimer's disease (AD) with an abnormally enhanced behavioral response to pitch perturbation. Here we examine the neural correlates of the abnormal pitch perturbation response in AD patients, using magnetoencephalographic imaging. The participants phonated the vowel /α/ while a real-time signal processor briefly perturbed the pitch (100 cents, 400 ms) of their auditory feedback. We examined the high-gamma band (65-150 Hz) responses during this task. AD patients showed significantly reduced left prefrontal activity during the early phase of perturbation and increased right middle temporal activity during the later phase of perturbation, compared to controls. Activity in these brain regions significantly correlated with the behavioral response. These results demonstrate that impaired prefrontal modulation of speech-motor-control network and additional recruitment of right temporal regions are significant mediators of aberrant sensorimotor integration in patients with AD. The abnormal neural integration mechanisms signify the contribution of cortical network dysfunction to cognitive and behavioral deficits in AD.
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