ArticleNature communications2019
Genetic studies of accelerometer-based sleep measures yield new insights into human sleep behaviour.
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In one paragraph
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 200 papers, 5 of them syntheses that pooled it.
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200citing papers in PubMed, 5 pooled it
30.1field-weighted citation impact, top 1% of its field
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Who cites it
200 citing papers in PubMed, 5 syntheses or guidelines pooled it, 322 citations in OpenAlex.
- Genome-wide gene-sleep interaction study identifies novel lipid loci in 732,564 participants.Atherosclerosis · 2026Pooled it
- Establishing causal relationships between sleep and adiposity traits using Mendelian randomization.Obesity (Silver Spring, Md.) · 2023Pooled it
- Putative Animal Models of Restless Legs Syndrome: A Systematic Review and Evaluation of Their Face and Construct Validity.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023Pooled it
- Using Mendelian Randomisation methods to understand whether diurnal preference is causally related to mental health.Molecular psychiatry · 2021Pooled it
- Genome-wide association analysis of self-reported daytime sleepiness identifies 42 loci that suggest biological subtypes.Nature communications · 2019Pooled it
- Estimating sleep parameters using an accelerometer without sleep diary.Scientific reports · 2018Trial
- Molecular correlates of sleep deprivation in the mouse brain identified by meta-analysis of microarray data.Neurobiology of sleep and circadian rhythms · 2026Article
- Epigenetic Insights and Exosome-Based Therapeutics for Insomnia: Bridging Sleep Biology and Precision Medicine.Molecular neurobiology · 2026Review
- Dissecting the shared genetic architecture and biological mechanisms linking sleep traits and suicide attempts: from variants to genes.Molecular psychiatry · 2026Article
- Association of Daily Activity Regularity With Functional Recovery in Patients With Stroke and Spinal Cord Injury: A Prospective Actigraphy Study.Annals of rehabilitation medicine · 2026Article
- The combined association between sleep duration and insomnia symptoms with dementia and cognitive deficits: a multivariable-adjusted and genetic liability study.GeroScience · 2026Article
- Poor sleep is robustly correlated with accelerated aging but the evidence for causation is mixed.medRxiv : the preprint server for health sciences · 2026Article
- Polygenic risk scores in neurological disorders: restless legs syndrome as a translational model.Medizinische Genetik : Mitteilungsblatt des Berufsverbandes Medizinische Genetik e.V · 2026Article
- Longitudinal Infant Sleep Monitoring Using a Sensor-Enabled Responsive Bassinet: A Population-Scale Feasibility Study.Sensors (Basel, Switzerland) · 2026Article
- Rare Coding Variants Reveal Distinct Genetic Architectures Across Multidimensional Sleep Phenotypes.medRxiv : the preprint server for health sciences · 2026Article
- Sleep and circadian health in the UK Biobank: report on the 2023 sleep questionnaire enhancement.Sleep · 2026Article
- Plasma proteomics of sleep traits reveals systemic immune-metabolic pathways and genetically prioritized proteins.Molecular psychiatry · 2026Article
- Multi-Omics Dissection of the Shared Genetic Architecture Between Sleep Traits and Epilepsy.Biology · 2026Article
- The Impact of Sunlight and Artificial Light at Night on Sleep Stages: Evidence From a 7-Day Sensor-Based Observational Study.JMIR mHealth and uHealth · 2026Observational
- Insomnia With Objective Short Sleep Duration Is Associated With Incident Cardiovascular and Cerebrovascular Disease: Evidence from the UK Biobank Data.Journal of the American Heart Association · 2026Article
140 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
32 authors at 13 institutions in 6 countries.
Samuel E JonesGenetics of Complex Traits, College of Medicine and Health, University of Exeter, Exeter, EX2 5DW, UK.ORCID http://orcid.org/0000-0003-0153-922X
Vincent T van HeesNetherlands eScience Center, Amsterdam, 1098 XG, The Netherlands.ORCID http://orcid.org/0000-0003-0182-9008
Diego R MazzottiCenter for Sleep and Circadian Neurobiology, University of Pennsylvania, Philadelphia, 19104, PA, USA.
Pedro Marques-VidalDepartment of Medicine, Internal Medicine, Lausanne University Hospital, Lausanne, 1011, Switzerland.ORCID http://orcid.org/0000-0002-4548-8500
Séverine SabiaResearch Department of Epidemiology and Public Health, University College London, London, WC1E 6BT, UK.
Ashley van der SpekDepartment of Epidemiology, Erasmus MC University Medical Center, Rotterdam, 3000 CA, The Netherlands.
Hassan S DashtiCenter for Genomic Medicine, Massachusetts General Hospital, Boston, MA, 02114, USA.ORCID http://orcid.org/0000-0002-1650-679X
Jorgen EngmannUCL Institute of Cardiovascular Science, Research department of Population Science and Experimental Medicine, Centre for Translational Genomics, 222 Euston Road, London, NW1 2DA, UK.
Desana KocevskaDepartment of Epidemiology, Erasmus MC University Medical Center, Rotterdam, 3000 CA, The Netherlands.
Jessica TyrrellGenetics of Complex Traits, College of Medicine and Health, University of Exeter, Exeter, EX2 5DW, UK.ORCID http://orcid.org/0000-0002-9256-6065
Robin N BeaumontGenetics of Complex Traits, College of Medicine and Health, University of Exeter, Exeter, EX2 5DW, UK.ORCID http://orcid.org/0000-0003-0750-8248
Melvyn HillsdonSport and Health Sciences, College of Life and Environmental Sciences, University of Exeter, Exeter, EX1 2LU, UK.
Katherine S RuthGenetics of Complex Traits, College of Medicine and Health, University of Exeter, Exeter, EX2 5DW, UK.ORCID http://orcid.org/0000-0003-4966-9170
Marcus A TukeGenetics of Complex Traits, College of Medicine and Health, University of Exeter, Exeter, EX2 5DW, UK.ORCID http://orcid.org/0000-0003-0008-9263
Hanieh YaghootkarGenetics of Complex Traits, College of Medicine and Health, University of Exeter, Exeter, EX2 5DW, UK.
Seth A SharpGenetics of Complex Traits, College of Medicine and Health, University of Exeter, Exeter, EX2 5DW, UK.
Yingjie JiGenetics of Complex Traits, College of Medicine and Health, University of Exeter, Exeter, EX2 5DW, UK.
Jamie W HarrisonGenetics of Complex Traits, College of Medicine and Health, University of Exeter, Exeter, EX2 5DW, UK.ORCID http://orcid.org/0000-0002-8314-9411
Rachel M FreathyGenetics of Complex Traits, College of Medicine and Health, University of Exeter, Exeter, EX2 5DW, UK.ORCID http://orcid.org/0000-0003-4152-2238
Anna MurrayGenetics of Complex Traits, College of Medicine and Health, University of Exeter, Exeter, EX2 5DW, UK.
Annemarie I LuikDepartment of Epidemiology, Erasmus MC University Medical Center, Rotterdam, 3000 CA, The Netherlands.
Najaf AminDepartment of Epidemiology, Erasmus MC University Medical Center, Rotterdam, 3000 CA, The Netherlands.
Jacqueline M LaneCenter for Genomic Medicine, Massachusetts General Hospital, Boston, MA, 02114, USA.
Richa SaxenaCenter for Genomic Medicine, Massachusetts General Hospital, Boston, MA, 02114, USA.
Martin K RutterDivision of Diabetes, Endocrinology and Gastroenterology, Faculty of Medicine, Biology and Health, University of Manchester, Manchester, M13 9PL, UK.
Henning TiemeierDepartment of Epidemiology, Erasmus MC University Medical Center, Rotterdam, 3000 CA, The Netherlands.
Zoltán KutalikInstitute of Social and Preventive Medicine (IUMSP), Lausanne University Hospital, Lausanne, 1010, Switzerland.ORCID http://orcid.org/0000-0001-8285-7523
Meena KumariISER, University of Essex, Colchester, Essex, CO4 3SQ, UK.
Timothy M FraylingGenetics of Complex Traits, College of Medicine and Health, University of Exeter, Exeter, EX2 5DW, UK.
Michael N WeedonGenetics of Complex Traits, College of Medicine and Health, University of Exeter, Exeter, EX2 5DW, UK. m.n.weedon@exeter.ac.uk.
Philip R GehrmanCenter for Sleep and Circadian Neurobiology, University of Pennsylvania, Philadelphia, 19104, PA, USA.
Andrew R WoodGenetics of Complex Traits, College of Medicine and Health, University of Exeter, Exeter, EX2 5DW, UK. a.r.wood@exeter.ac.uk.
University of Exeter · GBErasmus MC · NLBroad Institute · USCircadian (United States) · USBrigham and Women's Hospital · USGenomics (United Kingdom) · GBHarvard University · USInserm · FRManchester Academic Health Science Centre · GBNetherlands eScience Center · NLSIB Swiss Institute of Bioinformatics · CHUniversity of Essex · GBUniversity of Lausanne · CH
Funding
Genetics of chronotype and impact on metabolic diseaseR01DK107859 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Richa Saxena · 2016 to 2026
$4.0MElucidation of Genetic Effects on Sleep and Circadian TraitsR01HL143790 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI GEHRMAN, PHILIP RICHARD, GRANT, STRUAN F A · 2018 to 2021
$3.6MSocio-economic status and heterogeneity in agingR01AG013196 · NIA · UNIVERSITY OF LONDON INST OF NEUROLOGY · PI MARMOT, MICHAEL G, SINGH-MANOUX, ARCHANA · 1996 to 2013
$3.5MImpact of Malatonin, Food Timing and Receptor Variant on Type 2 Diabetes RiskR01DK105072 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI SAXENA, RICHA, SCHEER, FRANK A · 2016 to 2020
$3.2MHealth behaviors over the adult lifecourse and cognitive agingR01AG034454 · NIA · UNIVERSITY COLLEGE LONDON · PI KIVIMAKI, MIKA J, SINGH-MANOUX, ARCHANA · 2009 to 2013
$1.5MGenetic and molecular basis of circadian rhythm disordersK01HL136884 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI LANE, JACQUELINE MARIE · 2018 to 2022
$848kBritish Heart Foundation RG/16/11/32334Medical Research Council MR/M005070/1Medical Research Council MR/P012167/1Medical Research Council MR/R024227/1Medical Research Council MR/S011676/1NHLBI NIH HHS K01 HL136884NHLBI NIH HHS R01 HL143790NIA NIH HHS R01 AG013196NIA NIH HHS R01 AG034454NIDDK NIH HHS R01 DK105072NIDDK NIH HHS R01 DK107859Wellcome Trust
Abstract
Sleep is an essential human function but its regulation is poorly understood. Using accelerometer data from 85,670 UK Biobank participants, we perform a genome-wide association study of 8 derived sleep traits representing sleep quality, quantity and timing, and validate our findings in 5,819 individuals. We identify 47 genetic associations at P < 5 × 10
Indexed as
AccelerometryCircadian RhythmHumansPolymorphism, Single NucleotidePolysomnographySerotoninSleepSleep Wake DisordersWaist-Hip RatioSerotonin
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.