Evidence map›Paper›PMID 30952813›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2019

AMPA Receptor Dysregulation and Therapeutic Interventions in a Mouse Model of CDKL5 Deficiency Disorder.

Madhumita Yennawar, Rachel S White, Frances E Jensen

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
7.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 79 citations in OpenAlex.

  1. Article
  2. Review
  3. Transcriptomic Profiling of Zebrafish Mutant forInternational journal of molecular sciences · 2025
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  15. Roles of AMPA receptors in social behaviors.Frontiers in synaptic neuroscience · 2024
    Review
  16. Article
  17. Article
  18. Article
  19. mGluR5 PAMs rescue cortical and behavioural defects in a mouse model of CDKL5 deficiency disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023
    Article
  20. Epilepsy-Related CDKL5 Deficiency Slows Synaptic Vesicle Endocytosis in Central Nerve Terminals.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Madhumita YennawarDepartment of Systems Pharmacology and Translational Therapeutics, and.
Rachel S WhiteDepartment of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania 19104.ORCID 0000-0002-9645-057X
Frances E JensenDepartment of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania 19104 frances.jensen@uphs.upenn.edu.ORCID 0000-0001-7844-5518
University of Pennsylvania · USTranslational Therapeutics (United States) · US

Funding

The Intellectual and Developmental Disabilities Research Center at CHOP/PennU54HD086984 · NICHD · CHILDREN'S HOSP OF PHILADELPHIA · PI YUDKOFF, MARC · 2016 to 2020
$6.3M
Understanding the Cognitive Impact of Early Life EpilepsyDP1OD003347 · OD · UNIVERSITY OF PENNSYLVANIA · PI JENSEN, FRANCES E · 2007 to 2011
$4.2M
The Epileptogenic Effect of Perinatal HypoxiaR01NS031718 · NINDS · CHILDREN'S HOSPITAL BOSTON · PI JENSEN, FRANCES E · 1997 to 2011
$3.8M
Early Life Seizures Disrupt Critical Period PlasticityR01NS080565 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI HENSCH, TAKAO K, JENSEN, FRANCES E · 2013 to 2016
$1.8M
The Epileptogenic Effect of Perinatal HypoxiaR56NS031718 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI JENSEN, FRANCES E · 2007 to 2013
$907k
NICHD NIH HHS U54 HD086984NIH HHS DP1 OD003347NINDS NIH HHS R01 NS031718NINDS NIH HHS R01 NS080565NINDS NIH HHS R56 NS031718
6 · The paper itself

Abstract

Pathogenic mutations in cyclin-dependent kinase-like 5 (

Indexed as

AdultAnimalsBehavior, AnimalChild, PreschoolDisease Models, AnimalEpileptic SyndromesExcitatory Postsynaptic PotentialsFemaleGene Knock-In TechniquesHumansLearning DisabilitiesMaleMemory DisordersMiceMice, Inbred C57BLMice, Neurologic MutantsCDKL5 protein, mouseglutamate receptor ionotropic, AMPA 2Protein Serine-Threonine KinasesReceptors, AMPAautismbehaviorCDKL5excitabilitylearning and memory

Identifiers

PMID30952813
PMCPMC6561688
OpenAlexW2911295890

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.