Evidence map›Paper›PMID 30952808›Full record

ArticleClinical science (London, England : 1979)2019

Rhinovirus-induces progression of lung disease in a mouse model of COPD via IL-33/ST2 signaling axis.

Joao A Gimenes, Vikram Srivastava, Hymavathi ReddyVari, Sudhir Kotnala, Rahul Mishra, Mohamed Farazuddin, Wuyan Li, Umadevi S Sajjan

Open access · greenAbstract read
In one paragraph

Article in Clinical science (London, England : 1979), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. In Vivo Model to Assess the Nasal Infection by Minor Group Rhinovirus.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  3. Serum IL-33/ST2 Axis Expression in Acute Exacerbations of COPD: Correlation with Pulmonary Function.International journal of chronic obstructive pulmonary disease · 2025
    Article
  4. Article
  5. Respiratory virus infections and adenovirus characteristics during acute exacerbation of chronic obstructive pulmonary disease.Technology and health care : official journal of the European Society for Engineering and Medicine · 2024
    Article
  6. Review
  7. Review
  8. Article
  9. Review
  10. Article
  11. Rhinovirus and Innate Immune Function of Airway Epithelium.Frontiers in cellular and infection microbiology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Joao A GimenesDepartment of Thoracic Medicine and Surgery, Temple University, Philadelphia, PA, U.S.A.
Vikram SrivastavaDepartment of Thoracic Medicine and Surgery, Temple University, Philadelphia, PA, U.S.A.
Hymavathi ReddyVariDepartment of Thoracic Medicine and Surgery, Temple University, Philadelphia, PA, U.S.A.
Sudhir KotnalaDepartment of Thoracic Medicine and Surgery, Temple University, Philadelphia, PA, U.S.A.
Rahul MishraDepartment of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, MI, U.S.A.
Mohamed FarazuddinDepartment of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, MI, U.S.A.
Wuyan LiDepartment of Thoracic Medicine and Surgery, Temple University, Philadelphia, PA, U.S.A.
Umadevi S SajjanDepartment of Thoracic Medicine and Surgery, Temple University, Philadelphia, PA, U.S.A. uma.sajjan@temple.edu.ORCID 0000-0003-4967-413X
Temple University · USUniversity of Michigan · US

Funding

Quercetin prevents progression of COPD lung disease by modulating Foxo3AactivityR01AT007620 · NCCIH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SAJJAN, UMADEVI SIVANAPPA · 2014 to 2018
$2.0M
NCCIH NIH HHS R01 AT007620
6 · The paper itself

Abstract

Rhinovirus (RV), which is associated with acute exacerbations, also causes persistent lung inflammation in patients with chronic obstructive pulmonary disease (COPD), but the underlying mechanisms are not well-known. Recently, we demonstrated that RV causes persistent lung inflammation with accumulation of a subset of macrophages (CD11b

Indexed as

AnimalsChemokine CCL3Chemokine CXCL10Disease Models, AnimalDisease ProgressionFemaleHumansInterferon-gammaInterleukin-1 Receptor-Like 1 ProteinInterleukin-33LungMacrophagesMaleMiceMice, Inbred C57BLNeutrophilsChemokine CCL3Chemokine CXCL10Il1rl1 protein, mouseInterferon-gammaInterleukin-1 Receptor-Like 1 ProteinInterleukin-33CXCL-10EmphysemaexacerbationMacrophagesT cells

Identifiers

PMID30952808
PMCPMC9585538
OpenAlexW2934864598

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.