ArticleScience immunology2019
How C-terminal additions to insulin B-chain fragments create superagonists for T cells in mouse and human type 1 diabetes.
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In one paragraph
Article in Science immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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34citing papers in PubMed
5.6field-weighted citation impact, top 4% of its field
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 52 citations in OpenAlex.
- From Disposal to Display: Crinophagy as a β-Cell Source of Neoantigens in Type 1 Diabetes.Immunological reviews · 2026Review
- A microenvironment-driven HLA-II-associated insulin neoantigen elicits persistent memory T cell activation in diabetes.Nature immunology · 2026Article
- Structural insights into clonal restriction and diversity in T cell recognition of two immunodominant SARS-CoV-2 nucleocapsid epitopes.Nature communications · 2025Article
- Article
- Breakdown and Repair of Peripheral Immune Tolerance in Type 1 Diabetes.Cold Spring Harbor perspectives in medicine · 2024Review
- The insulin secretory granule is a hotspot for autoantigen formation in type 1 diabetes.Diabetologia · 2024Review
- Antigen-specific T cell responses in autoimmune diabetes.Frontiers in immunology · 2024Review
- Insulin-degrading enzyme regulates insulin-directed cellular autoimmunity in murine type 1 diabetes.Frontiers in immunology · 2024Article
- Tracking DNA-based antigen-specific T cell receptors during progression to type 1 diabetes.Science advances · 2023Article
- A mutagenesis study of autoantigen optimization for potential T1D vaccine design.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Regulatory T cells targeting a pathogenic MHC class II: Insulin peptide epitope postpone spontaneous autoimmune diabetes.Frontiers in immunology · 2023Article
- A guide to antigen processing and presentation.Nature reviews. Immunology · 2022Review
- Article
- Review
- Tolerogenic Delivery of a Hybrid Insulin Peptide Markedly Prolongs Islet Graft Survival in the NOD Mouse.Diabetes · 2022Article
- Calcitonin gene-related peptide is a potential autoantigen for CD4 T cells in type 1 diabetes.Frontiers in immunology · 2022Article
- A Novel Tolerogenic Antibody Targeting Disulfide-Modified Autoantigen Effectively Prevents Type 1 Diabetes in NOD Mice.Frontiers in immunology · 2022Article
- Structural plasticity in I-AFrontiers in immunology · 2022Article
- Peptide Centric Vβ Specific Germline Contacts Shape a Specialist T Cell Response.Frontiers in immunology · 2022Article
- Know thy immune self and non-self: Proteomics informs on the expanse of self and non-self, and how and where they arise.Proteomics · 2021Review
Corrections and comments
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Authors and funding
16 authors at 4 institutions in 1 country.
Yang WangDepartment of Biomedical Research, National Jewish Health, Denver, CO 80206, USA.ORCID 0000-0002-6510-6653
Tomasz SosinowskiBarbara Davis Center for Childhood Diabetes, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Andrey NovikovDepartment of Biomedical Research, National Jewish Health, Denver, CO 80206, USA.ORCID 0000-0002-1425-6109
Frances CrawfordDepartment of Biomedical Research, National Jewish Health, Denver, CO 80206, USA.
Janice WhiteDepartment of Biomedical Research, National Jewish Health, Denver, CO 80206, USA.
Niyun JinDepartment of Biomedical Research, National Jewish Health, Denver, CO 80206, USA.ORCID 0000-0002-7816-4211
Zikou LiuDepartment of Biomedical Research, National Jewish Health, Denver, CO 80206, USA.
Jinhao ZouDepartment of Biomedical Research, National Jewish Health, Denver, CO 80206, USA.ORCID 0000-0002-0710-9581
David NeauDepartment of Chemistry and Chemical Biology, Cornell University, NE-CAT, Advanced Photon Source, Argonne National Laboratory, Argonne, IL 60439, USA.
Howard W DavidsonDepartment of Immunology and Microbiology, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.ORCID 0000-0001-5605-3812
Maki NakayamaDepartment of Immunology and Microbiology, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.ORCID 0000-0002-0009-3687
William W KwokBenaroya Research Institute, Seattle, WA 98101, USA.ORCID 0000-0003-4843-4599
Laurent GapinDepartment of Immunology and Microbiology, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Philippa MarrackDepartment of Biomedical Research, National Jewish Health, Denver, CO 80206, USA.ORCID 0000-0003-1883-3687
John W KapplerDepartment of Biomedical Research, National Jewish Health, Denver, CO 80206, USA. kapplerj@njhealth.org shaodong.dai@ucdenver.edu.ORCID 0000-0002-5827-6240
Shaodong DaiDepartment of Biomedical Research, National Jewish Health, Denver, CO 80206, USA. kapplerj@njhealth.org shaodong.dai@ucdenver.edu.ORCID 0000-0003-4760-2773
National Jewish Health · USUniversity of Colorado Anschutz Medical Campus · USArgonne National Laboratory · USBenaroya Research Institute
Funding
User Training and OutreachP30GM124165 · NIGMS · CORNELL UNIVERSITY · PI Nozomi Ando, J Christopher Fromme · 2018 to 2026
$34.2MOverall EvaluationP41GM103403 · NIGMS · CORNELL UNIVERSITY · PI EALICK, STEVEN E · 2012 to 2017
$14.3MProject 3: Epitope Selection in Type 1 DiabetesP01AI118688 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KAPPLER, JOHN W · 2016 to 2020
$8.4MCHARACTERISTICS OF T CELL RECEPTORSR01AI018785 · NIAID · NATIONAL JEWISH HEALTH · PI MARRACK, PHILIPPA C. · 1985 to 2022
$7.3MMultiple Autoantigens/Multiple Epitopes of Type 1DMR01DK032083 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI MICHELS, AARON W · 1986 to 2025
$6.9MMolecular Dissection of Insulin Targeting in Anti-Islet AutoimmunityR01DK099317 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI AARON W MICHELS, Maki Nakayama · 2013 to 2026
$5.3MMolecular Mechanisms of Immune ToleranceT32AI074491 · NIAID · NATIONAL JEWISH HEALTH · PI CAMBIER, JOHN C, PELANDA, ROBERTA · 2009 to 2023
$4.1MInsulin Specific T Cell Response Shaped by Diabetes Protective MHC Class II MoleculesR01DK108868 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI AARON W MICHELS · 2017 to 2026
$3.6MColorado Clinical and Translational Sciences InstituteKL2TR001080 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2013 to 2017
$2.6MPixel Array Detector for X-ray CrystallographyS10RR029205 · NCRR · CORNELL UNIVERSITY · PI EALICK, STEVEN E · 2010 to 2010
$1.8MMolecular Basis of T Cell Recognition of Metal IonsR01ES025797 · NIEHS · UNIVERSITY OF COLORADO DENVER · PI DAI, SHAODONG · 2015 to 2019
$1.8MInsulin Specific T and B cells in Type 1 DiabetesDP3DK110845 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI CAMBIER, JOHN C, MICHELS, AARON W · 2016 to 2016
$1.7MNCATS NIH HHS KL2 TR001080NCRR NIH HHS S10 RR029205NIAID NIH HHS P01 AI118688NIAID NIH HHS R01 AI018785NIAID NIH HHS R37 AI018785NIAID NIH HHS R56 AI018785NIAID NIH HHS T32 AI074491NIDDK NIH HHS DP3 DK110845NIDDK NIH HHS R01 DK032083NIDDK NIH HHS R01 DK099317NIDDK NIH HHS R01 DK108868NIDDK NIH HHS R37 DK032083NIEHS NIH HHS R01 ES025797NIEHS NIH HHS R21 ES025885NIGMS NIH HHS P30 GM124165NIGMS NIH HHS P41 GM103403
Abstract
In type 1 diabetes (T1D), proinsulin is a major autoantigen and the insulin B:9-23 peptide contains epitopes for CD4
Indexed as
Amino Acid SequenceAnimalsAutoantigensCD4-Positive T-LymphocytesCell Line, TumorDiabetes Mellitus, Type 1Epitopes, T-LymphocyteHLA-DQ AntigensHumansHybridomasImmune ToleranceInsulinLysosomesMiceMice, Inbred NODMolecular Docking SimulationAutoantigensEpitopes, T-LymphocyteHLA-DQ AntigensInsulininsulin B (9-23)Peptide FragmentsReceptors, Antigen, T-Cell
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What OpenQuestion holds
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.