Evidence map›Paper›PMID 30952781›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2019

Complete biosynthetic pathways of ascofuranone and ascochlorin in

Yasuko Araki, Takayoshi Awakawa, Motomichi Matsuzaki, Rihe Cho, Yudai Matsuda, Shotaro Hoshino, Yasutomo Shinohara, Masaichi Yamamoto, Yasutoshi Kido, Daniel Ken Inaoka and 4 more

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed
7.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 104 citations in OpenAlex.

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  14. Sequential Reconstruction of Calicheamicin γAngewandte Chemie (International ed. in English) · 2025
    Article
  15. Article
  16. Article
  17. Article
  18. Advances in the Study of Halogenated Natural Products.Current topics in medicinal chemistry · 2025
    Review
  19. Genome Sequencing and Metabolic Potential Analysis ofJournal of fungi (Basel, Switzerland) · 2024
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 1 country.

Yasuko ArakiResearch and Development Division, Kikkoman Corporation, Noda City, Chiba 278-0037, Japan.
Takayoshi AwakawaGraduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-0033, Japan.ORCID 0000-0003-2575-3175
Motomichi MatsuzakiDepartment of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan; matsuzaki@05.alumni.u-tokyo.ac.jp abei@mol.f.u-tokyo.ac.jp.ORCID 0000-0001-5811-798X
Rihe ChoDepartment of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan.
Yudai MatsudaGraduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-0033, Japan.ORCID 0000-0001-5650-4732
Shotaro HoshinoGraduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-0033, Japan.
Yasutomo ShinoharaResearch and Development Division, Kikkoman Corporation, Noda City, Chiba 278-0037, Japan.
Masaichi YamamotoInstitute of Mitochondrial Science Company, Ltd., Tokyo 176-0025, Japan.
Yasutoshi KidoDepartment of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan.
Daniel Ken InaokaDepartment of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan.
Kisaburo NagamuneDepartment of Parasitology, National Institute of Infectious Diseases, Tokyo 162-8640, Japan.
Kotaro ItoResearch and Development Division, Kikkoman Corporation, Noda City, Chiba 278-0037, Japan.
Ikuro AbeGraduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo 113-0033, Japan; matsuzaki@05.alumni.u-tokyo.ac.jp abei@mol.f.u-tokyo.ac.jp.ORCID 0000-0002-3640-888X
Kiyoshi KitaDepartment of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan.ORCID 0000-0002-0426-4308
The University of Tokyo · JPKikkoman (Japan) · JPNagasaki University · JPNational Institute of Infectious Diseases · JPOsaka City University · JPUniversity of Tsukuba · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ascofuranone (AF) and ascochlorin (AC) are meroterpenoids produced by various filamentous fungi, including

Indexed as

AcremoniumAlkenesPhenolsSesquiterpenesBiosynthetic PathwaysFungal ProteinsGenes, FungalModels, MolecularMultigene FamilyAlkenesascochlorinascofuranoneFungal ProteinsPhenolsSesquiterpenesAfrican trypanosomiasisascochlorinascofuranonesecondary metabolismterpene cyclase

Identifiers

PMID30952781
PMCPMC6486709
OpenAlexW2928034087

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.