Evidence map›Paper›PMID 30952677›Full record

ArticleDrug metabolism and disposition: the biological fate of chemicals2019

Rolapitant Is a Reversible Inhibitor of CYP2D6.

Sarah M Glass, Sabrina M Leddy, Michael C Orwin, Garret P Miller, Kyle A Furge, Laura Lowe Furge

Abstract read
In one paragraph

Article in Drug metabolism and disposition: the biological fate of chemicals, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Rolapitant treats lung cancer by targeting deubiquitinase OTUD3.Cell communication and signaling : CCS · 2024
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sarah M GlassDepartment of Chemistry, Kalamazoo College, Kalamazoo, Michigan.
Sabrina M LeddyDepartment of Chemistry, Kalamazoo College, Kalamazoo, Michigan.
Michael C OrwinDepartment of Chemistry, Kalamazoo College, Kalamazoo, Michigan.
Garret P MillerDepartment of Chemistry, Kalamazoo College, Kalamazoo, Michigan.
Kyle A FurgeDepartment of Chemistry, Kalamazoo College, Kalamazoo, Michigan.
Laura Lowe FurgeDepartment of Chemistry, Kalamazoo College, Kalamazoo, Michigan Laura.Furge@kzoo.edu.

Funding

The Effect of Genetic Diversity on Mechanism-Based Inactivation of CYP2D6R15GM086767 · NIGMS · KALAMAZOO COLLEGE · PI FURGE, KYLE A, FURGE, LAURA L · 2009 to 2017
$1.1M
Howard Hughes Medical Institute 52006304NIGMS NIH HHS R15 GM086767
6 · The paper itself

Abstract

Rolapitant [(Varubi), 5

Indexed as

Catalytic DomainCytochrome P-450 CYP2D6Cytochrome P-450 CYP2D6 InhibitorsDextromethorphanDrug InteractionsEthanolaminesHumansSpiro CompoundsbufuralolCytochrome P-450 CYP2D6Cytochrome P-450 CYP2D6 InhibitorsDextromethorphanEthanolaminesrolapitantSpiro Compounds

Identifiers

PMID30952677
PMCPMC6505376

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.