ArticleImmunity2019
Loss of Neurological Disease HSAN-I-Associated Gene SPTLC2 Impairs CD8
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Article in Immunity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 54 citations in OpenAlex.
- Metabolites beyond metabolism: Exploring their atypical roles in protein modification and signaling transduction.Chinese medical journal · 2026Review
- The SGLT2 Inhibitor Dapagliflozin Disrupts the Cell Cycle at High Concentrations Without Altering Glycosphingolipid (De Novo)Biosynthesis.International journal of molecular sciences · 2025Article
- Ceramide signaling in immunity: a molecular perspective.Lipids in health and disease · 2025Review
- Metabolic reprogram and T cell differentiation in inflammation: current evidence and future perspectives.Cell death discovery · 2025Review
- SPTLC2 drives an EGFR-FAK-HBEGF signaling axis to promote ovarian cancer progression.Oncogene · 2025Article
- Altered metabolomics and inflammatory transcriptomics in human bone marrow adipocytes after acute high calorie diet and acute fasting.Frontiers in endocrinology · 2025Article
- Evaluation of the diagnostic utility of immune microenvironment-related biomarkers in endometriosis using multidimensional transcriptomic data.Journal of assisted reproduction and genetics · 2024Article
- Sphinganine recruits TLR4 adaptors in macrophages and promotes inflammation in murine models of sepsis and melanoma.Nature communications · 2024Article
- Cellular metabolism regulates the differentiation and function of T-cell subsets.Cellular & molecular immunology · 2024Review
- Sphingolipid biosynthesis is essential for metabolic rewiring during TScience advances · 2024Article
- Article
- Navigating the landscape of the unfolded protein response in CD8Frontiers in immunology · 2024Review
- Article
- The malate shuttle detoxifies ammonia in exhausted T cells by producing 2-ketoglutarate.Nature immunology · 2023Article
- Mutation screening of SPTLC1 and SPTLC2 in amyotrophic lateral sclerosis.Human genomics · 2023Article
- Unraveling the phenotypic and genomic background of behavioral plasticity and temperament in North American Angus cattle.Genetics, selection, evolution : GSE · 2023Article
- Metabolic regulation of immune responses to cancer.Cancer biology & medicine · 2022Review
- Population genomics of an icefish reveals mechanisms of glacier-driven adaptive radiation in Antarctic notothenioids.BMC biology · 2022Article
- 1-Deoxysphingolipid synthesis compromises anchorage-independent growth and plasma membrane endocytosis in cancer cells.Journal of lipid research · 2022Article
- Screening of sphingolipid metabolism-related genes associated with immune cells in myocardial infarction: a bioinformatics analysis.Journal of thoracic disease · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
28 authors at 9 institutions in 6 countries.
Jingxia WuT Cell Metabolism Group (D140), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.
Sicong MaT Cell Metabolism Group (D140), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany; Medical Faculty Heidelberg, Heidelberg University, 69120 Heidelberg, Germany.
Roger SandhoffLipid Pathobiochemistry Group (G131), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.
Yanan MingInternal Medicine IV, University Heidelberg Hospital, Im Neuenheimer Feld 345, 69120 Heidelberg, Germany.
Agnes Hotz-WagenblattCore Facility Omics IT and Data Management, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.
Vincent TimmermanPeripheral Neuropathy Research Group, Department of Biomedical Sciences, Institute Born Bunge, B-2610, University of Antwerp, Antwerpen, Belgium.
Nathalie Bonello-PalotDepartment of Medical Genetics, Children Timone Hospital, 264 Rue Saint Pierre & Aix Marseille University, INSERM, MMG, U1251, 13385 Marseille, France.
Beate Schlotter-WeigelFriedrich-Baur-Institut, Neurologische Klinik and Poliklinik Ludwig-Maximilians-Universität, 80336 München, Germany.
Michaela Auer-GrumbachDepartment of Orthopaedics and Trauma Surgery, Medical University of Vienna, Vienna, Austria.
Pavel SeemanDNA Laboratory, Department of Child Neurology, 2nd Medical School, University Hospital Motol, Charles University, Prague, Czech Republic.
Wolfgang N LöscherClinical Department of Neurology, Medical University Innsbruck, Anichstr. 35, 6020 Innsbruck, Austria.
Markus ReindlClinical Department of Neurology, Medical University Innsbruck, Anichstr. 35, 6020 Innsbruck, Austria.
Florian WeissDepartment of Psychiatry and Psychotherapy, University Hospital of Psychiatry, Bolligenstrasse 111, 3000 Bern, Germany.
Eric MahSchool of Medicine, UC San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
Nina WeisshaarT Cell Metabolism Group (D140), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany; Faculty of Biosciences, Heidelberg University, 69120 Heidelberg, Germany.
Alaa MadiT Cell Metabolism Group (D140), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany; Faculty of Biosciences, Heidelberg University, 69120 Heidelberg, Germany.
Kerstin MohrT Cell Metabolism Group (D140), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.
Tilo SchlimbachT Cell Metabolism Group (D140), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.
Rubí M-H Velasco CárdenasT Cell Metabolism Group (D140), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.
Jonas KoeppelT Cell Metabolism Group (D140), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.
Florian GrünschlägerT Cell Metabolism Group (D140), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.
Lisann MüllerT Cell Metabolism Group (D140), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.
Maren BaumeisterT Cell Metabolism Group (D140), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.
Britta BrüggerHeidelberg University Biochemistry Center (BZH), Im Neuenheimer Feld 328, Heidelberg, Germany.
Michael SchmittInternal Medicine V, University Heidelberg Hospital, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.
Guido WabnitzSection Molecular Immunology, Institute of Immunology, Heidelberg University, Im Neuenheimer Feld 305, 69120 Heidelberg, Germany.
Yvonne SamstagSection Molecular Immunology, Institute of Immunology, Heidelberg University, Im Neuenheimer Feld 305, 69120 Heidelberg, Germany.
Guoliang CuiT Cell Metabolism Group (D140), German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany; Faculty of Biosciences, Heidelberg University, 69120 Heidelberg, Germany. Electronic address: g.cui@dkfz.de.
German Cancer Research Center · DEHeidelberg University · DEInnsbruck Medical University · ATCharles University · CZInserm · FRLudwig-Maximilians-Universität München · DEMedical University of Vienna · ATUniversity of Antwerp · BEUniversity of California San Diego · US
Funding
UC San Diego Clinical and Translational Research InstituteUL1TR001442 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S, HOGARTH, MICHAEL · 2015 to 2024
$88.3MAustrian Science Fund FWF P 27634NCATS NIH HHS UL1 TR001442
Abstract
Patients with the neurological disorder HSAN-I suffer frequent infections, attributed to a lack of pain sensation and failure to seek care for minor injuries. Whether protective CD8
Indexed as
AnimalsCD8-Positive T-LymphocytesCell ProliferationCells, CulturedCytokinesEndoplasmic Reticulum StressFemaleHereditary Sensory and Autonomic NeuropathiesHumansLymphocytic ChoriomeningitisLymphocytic choriomeningitis virusMaleMechanistic Target of Rapamycin Complex 1MiceMice, Inbred C57BLMiddle AgedCytokinesMechanistic Target of Rapamycin Complex 1Serine C-PalmitoyltransferaseSphingolipidsSPTLC2 protein, humanCD8+ T cellsER stressHSAN-Ineurological diseasesSPTLC2
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.