Evidence map›Paper›PMID 30952606›Full record

ArticleImmunity2019

Keratinocyte-Mediated Activation of the Cytokine TGF-β Maintains Skin Recirculating Memory CD8

Toshiro Hirai, Yukari Zenke, Yi Yang, Laurent Bartholin, Lalit K Beura, David Masopust, Daniel H Kaplan

Open access · bronzeAbstract read
In one paragraph

Article in Immunity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 1 pooled it
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 1 synthesis or guideline pooled it, 82 citations in OpenAlex.

  1. Tissue-Resident Memory T Cells in Skin Diseases: A Systematic Review.International journal of molecular sciences · 2021
    Pooled it
  2. Article
  3. Review
  4. Article
  5. PD-1 is requisite for skin TNature immunology · 2025
    Article
  6. Article
  7. Cutaneous T cell immunity.Nature immunology · 2025
    Review
  8. CXCR6 promotes dermal CD8bioRxiv : the preprint server for biology · 2025
    Article
  9. Review
  10. Review
  11. CD4Frontiers in immunology · 2025
    Article
  12. Review
  13. Article
  14. Intraepithelial Lymphocytes of the Intestine.Annual review of immunology · 2024
    Review
  15. Review
  16. CD8Frontiers in immunology · 2024
    Review
  17. Review
  18. From the Skin to Distant Sites: T Cells in Psoriatic Disease.International journal of molecular sciences · 2023
    Review
  19. Cross-presenting Langerhans cells are required for the early reactivation of resident CD8Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  20. Lung dopaminergic nerves facilitate the establishment of TThe Journal of allergy and clinical immunology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 4 countries.

Toshiro HiraiDepartment of Dermatology, University of Pittsburgh, Pittsburgh, PA 15261, USA; Department of Immunology, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Yukari ZenkeDepartment of Dermatology, University of Pittsburgh, Pittsburgh, PA 15261, USA; Department of Immunology, University of Pittsburgh, Pittsburgh, PA 15261, USA; Department of Dermatology, St. Luke's International Hospital, Tokyo, Japan.
Yi YangDepartment of Dermatology, University of Pittsburgh, Pittsburgh, PA 15261, USA; Department of Immunology, University of Pittsburgh, Pittsburgh, PA 15261, USA; Department of Dermatology, Xiangya Hospital, Central South University, Changsha, China; The Third Xiangya Hospital, Central South University, Changsha, China.
Laurent BartholinUniversité de Lyon, Université Claude Bernard Lyon 1, INSERM 1052, CNRS 5286, Centre Léon Bérard, Centre de Recherche en Cancérologie de Lyon (CRCL), Lyon 69008, France.
Lalit K BeuraDepartment of Microbiology and Immunology, Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA.
David MasopustDepartment of Microbiology and Immunology, Center for Immunology, University of Minnesota, Minneapolis, MN 55455, USA.
Daniel H KaplanDepartment of Dermatology, University of Pittsburgh, Pittsburgh, PA 15261, USA; Department of Immunology, University of Pittsburgh, Pittsburgh, PA 15261, USA. Electronic address: dankaplan@pitt.edu.
University of Minnesota · USUniversity of Pittsburgh · USCentre de Recherche en Cancérologie de Lyon · FRSt. Luke's International Hospital · JPXiangya Hospital Central South University · CN

Funding

Women's CancerP30CA077598 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Douglas Yee · 1998 to 2026
$100.4M
REGULATION OF LACTOSAMINYL GLYCAN BIOSYNTHESIS IN HEMATOPOIETIC CELLSP01HL107146 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SACKSTEIN, ROBERT · 2011 to 2017
$17.7M
Regulated Activation of Latent-TGFb Determines Leukocyte Occupancy of the Epidermal NicheR01AR060744 · NIAMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KAPLAN, DANIEL H · 2011 to 2020
$4.0M
Special BD LSRFortessaTMS10OD011925 · OD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BORGHESI, LISA · 2012 to 2012
$383k
NCI NIH HHS P30 CA077598NHLBI NIH HHS P01 HL107146NIAMS NIH HHS R01 AR060744NIH HHS S10 OD011925
6 · The paper itself

Abstract

Regulated activation of the cytokine TGF-β by integrins α

Indexed as

AnimalsAntigens, NeoplasmCD8-Positive T-LymphocytesCell DifferentiationCytokinesEnzyme ActivationFemaleImmunologic MemoryIntegrinsKeratinocytesMaleMiceMice, Inbred C57BLSkinTransforming Growth Factor betaVaccinia virusAntigens, NeoplasmCytokinesintegrin alphavbeta6integrin alphavbeta8IntegrinsTransforming Growth Factor betaCD8(+) T cell memorykeratinocytesskintransforming growth factor betaα(v)β(6)α(v)β(8)

Identifiers

PMID30952606
PMCPMC6531326
OpenAlexW2930723622

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.