Evidence map›Paper›PMID 30952509›Full record

Trial reportThe Journal of pediatrics2019

Markers of Systemic Inflammation and Environmental Enteric Dysfunction Are Not Reduced by Zinc or Multivitamins in Tanzanian Infants: A Randomized, Placebo-Controlled Trial.

Jacqueline M Lauer, Christine M McDonald, Rodrick Kisenge, Said Aboud, Wafaie W Fawzi, Enju Liu, Hao Q Tran, Andrew T Gewirtz, Karim P Manji, Christopher P Duggan

Registry-linked trialOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of pediatrics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00421668 (A Trial of Zinc and Micronutrients in Tanzanian Children), which is not on this map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00421668 phase3completednot on this map

A Trial of Zinc and Micronutrients in Tanzanian Children

TypeinterventionalSponsorHarvard School of Public Health (HSPH)Ran2007 to 2012Enrolled2,400ConditionsDiarrheal Illnesses, Respiratory Illness, Growth FalteringArmsZinc, Multivitamins, Placebo
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Trial
  5. Maternal Aflatoxin Exposure, Birth Outcomes, and Infant Growth in Uganda.The American journal of tropical medicine and hygiene · 2026
    Article
  6. Article
  7. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Jacqueline M LauerDivision of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, MA. Electronic address: Jacqueline.Lauer@childrens.harvard.edu.
Christine M McDonaldChildren's Hospital Oakland Research Institute, Oakland, CA.
Rodrick KisengeDepartment of Pediatrics and Child Health, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
Said AboudDepartment of Microbiology and Immunology, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
Wafaie W FawziDepartment of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, MA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA.
Enju LiuDivision of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, MA; Institutional Centers of Clinical and Translational Research, Boston Children's Hospital, Boston, MA.
Hao Q TranInstitute for Biomedical Sciences, Georgia State University, Atlanta, GA.
Andrew T GewirtzInstitute for Biomedical Sciences, Georgia State University, Atlanta, GA.
Karim P ManjiDepartment of Pediatrics and Child Health, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
Christopher P DugganDivision of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, MA; Department of Pediatrics and Child Health, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania; Department of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, MA; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA.
Boston Children's Hospital · USMuhimbili University of Health and Allied Sciences · TZGeorgia State University · USHarvard University · US

Funding

ROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI CHRISTOPHER P DUGGAN · 1994 to 2026
$31.6M
A Trial of Zinc and Micronutrients in Tanzanian ChildrenR01HD048969 · NICHD · HARVARD SCHOOL OF PUBLIC HEALTH · PI DUGGAN, CHRISTOPHER P · 2006 to 2010
$2.0M
Patient-oriented Research in Pediatric Diarrheal DiseasesK24DK104676 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI DUGGAN, CHRISTOPHER P · 2015 to 2019
$903k
NICHD NIH HHS R01 HD048969NIDDK NIH HHS K24 DK104676NIDDK NIH HHS P30 DK040561
6 · The paper itself

Abstract

objectiveTo examine whether daily zinc and/or multivitamin supplementation reduce biomarkers of environmental enteric dysfunction (EED), systemic inflammation, or markers of growth in a sample of infants from Dar es Salaam, Tanzania. STUDY

designSubgroup analysis of infants participating in a randomized, double-blind, placebo-controlled trial received daily oral supplementation of zinc, multivitamins, zinc + multivitamins, or placebo for 18 months starting at 6 weeks of age. EED (anti-flagellin and anti-lipopolysaccharide immunoglobulins), systemic inflammation (C-reactive protein and alpha-1-acid glycoprotein), and growth biomarkers (insulin-like growth factor-1 and insulin-like growth factor binding protein-3) were measured via enzyme-linked immunosorbent assay in a subsample of 590 infants at 6 weeks and 6 months of age. EED biomarkers also were measured in 162 infants at 12 months of age.

resultsWith the exception of anti-lipopolysaccharide IgG concentrations, which were significantly greater in infants who received multivitamins compared with those who did not (1.41 ± 0.61 vs 1.26 ± 0.65, P = .006), and insulin-like growth factor binding protein-3 concentrations, which were significantly lower in children who received zinc compared with those who did not (981.13 ± 297.59 vs 1019.10 ± 333.01, P = .03), at 6 months of age, we did not observe any significant treatment effects of zinc or multivitamins on EED, systemic inflammation, or growth biomarkers.

conclusionsNeither zinc nor multivitamin supplementation ameliorated markers of EED or systemic inflammation during infancy. Other interventions should be prioritized for future trials.

trial registrationClinicaltrials.gov: NCT00421668.

Indexed as

Dietary SupplementsIntestine, SmallBiomarkersDouble-Blind MethodFemaleHumansInfantInflammationIntestinal DiseasesMaleTanzaniaTreatment OutcomeVitaminsZincBiomarkersVitaminsZincalpha-1-acid glycoproteinanti-flagellinanti-LPSC-reactive proteininsulin-like growth factor-1insulin-like growth factor binding protein-3

Identifiers

PMID30952509
PMCPMC6590867
OpenAlexW2934801635

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.