Evidence map›Paper›PMID 30952214›Full record

ArticleJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine2019

A Global Comparison of Anatomic Risk Factors and Their Relationship to Obstructive Sleep Apnea Severity in Clinical Samples.

Kate Sutherland, Brendan T Keenan, Lia Bittencourt, Ning-Hung Chen, Thorarinn Gislason, Sarah Leinwand, Ulysses J Magalang, Greg Maislin, Diego R Mazzotti, Nigel McArdle and 8 more

Open access · bronzeAbstract readComparative StudyMulticenter Study
In one paragraph

Article in Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 3 pooled it
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 3 syntheses or guidelines pooled it, 73 citations in OpenAlex.

  1. Effectiveness of mandibular advancement devices in obstructive sleep apnea therapy for East Asian patients: a systematic review and meta-analysis.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025
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  4. Should weight loss be the first-line treatment for obstructive sleep apnoea? A pro-con debate.European respiratory review : an official journal of the European Respiratory Society · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 8 institutions in 6 countries.

Kate SutherlandDepartment of Respiratory and Sleep Medicine, Royal North Shore Hospital, Sydney, New South Wales, Australia.
Brendan T KeenanCenter for Sleep and Circadian Neurobiology, University of Pennsylvania, Philadelphia, Pennsylvania.
Lia BittencourtDisciplilna de Medicina e Biologia do Sono, Departamento de Psicobiologia, Universidade Federal de Sao Paulo, Sao Paulo, Brazil.
Ning-Hung ChenSleep Center, Department of Pulmonary and Critical Care Medicine; Chang Gung Memorial Hospital, Taoyuan, Taiwan.
Thorarinn GislasonDepartment of Respiratory Medicine and Sleep, Landspitali -The National University Hospital of Iceland and Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
Sarah LeinwandCenter for Sleep and Circadian Neurobiology, University of Pennsylvania, Philadelphia, Pennsylvania.
Ulysses J MagalangDivision of Pulmonary, Critical Care, and Sleep Medicine, The Ohio State Wexner Medical Center, Columbus, Ohio.
Greg MaislinDivision of Sleep Medicine, Perelman School of Medicine at the University of Pennsylvania.
Diego R MazzottiCenter for Sleep and Circadian Neurobiology, University of Pennsylvania, Philadelphia, Pennsylvania.
Nigel McArdleWest Australian Sleep Disorders Research Institute; Department of Pulmonary Physiology and Sleep Medicine, Sir Charles Gairdner Hospital; University of Western Australia, Perth, Western Australia, Australia.
Jesse MindelDivision of Pulmonary, Critical Care, and Sleep Medicine, The Ohio State Wexner Medical Center, Columbus, Ohio.
Allan I PackCenter for Sleep and Circadian Neurobiology, University of Pennsylvania, Philadelphia, Pennsylvania.
Thomas PenzelCenter of Sleep Medicine, Charité University Hospital, Berlin, Germany.
Bhajan SinghWest Australian Sleep Disorders Research Institute; Department of Pulmonary Physiology and Sleep Medicine, Sir Charles Gairdner Hospital; University of Western Australia, Perth, Western Australia, Australia.
Sergio TufikDisciplilna de Medicina e Biologia do Sono, Departamento de Psicobiologia, Universidade Federal de Sao Paulo, Sao Paulo, Brazil.
Richard J SchwabCenter for Sleep and Circadian Neurobiology, University of Pennsylvania, Philadelphia, Pennsylvania.
Peter A CistulliDepartment of Respiratory and Sleep Medicine, Royal North Shore Hospital, Sydney, New South Wales, Australia.
SAGIC Investigators
University of Pennsylvania · USThe Ohio State University Wexner Medical Center · USThe University of Sydney · AUThe University of Western Australia · AUUniversidade Federal de São Paulo · BRChang Gung Memorial Hospital · TWCharité - Universitätsmedizin Berlin · DEUniversity of Iceland · IS

Funding

Understanding the relationship between obesity and tongue fat in humans and ratsP01HL094307 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI PACK, ALLAN I · 2009 to 2020
$23.7M
The Ohio State University Center for clinical and Translational ScienceUL1TR001070 · NCATS · OHIO STATE UNIVERSITY · PI JACKSON, REBECCA D · 2013 to 2017
$22.6M
NCATS NIH HHS UL1 TR001070NHLBI NIH HHS P01 HL094307
6 · The paper itself

Abstract

STUDY

objectivesObstructive sleep apnea (OSA) is a global health issue and is associated with obesity and oropharyngeal crowding. Global data are limited on the effect of ethnicity and sex on these relationships. We compare associations between the apnea-hypopnea index (AHI) and these risk factors across ethnicities and sexes within sleep clinics.

methodsThis is a cross-sectional, multicenter study of patients with OSA from eight sleep centers representing the Sleep Apnea Global Interdisciplinary Consortium (SAGIC). Four distinct ethnic groups were analyzed, using a structured questionnaire: Caucasians (Australia, Iceland, Germany, United States), African Americans (United States), Asians (Taiwan), and South Americans (Brazil). Regression analyses and interaction tests were used to assess ethnic and sex differences in relationships between AHI and anthropometric measures (body mass index [BMI], neck circumference, waist circumference) or Mallampati score.

resultsAnalyses included 1,585 individuals from four ethnic groups: Caucasian (60.6%), African American (17.5%), Asian (13.1%), and South American (8.9%). BMI was most strongly associated with AHI in South Americans (7.8% increase in AHI per 1 kg/m

conclusionsWe demonstrate ethnic and sex variations in associations between obesity and OSA. For similar BMI increases, South American patients show greatest AHI increases compared to African Americans. Findings highlight the importance of considering ethnicity and sex in clinical assessments of OSA risk.

Indexed as

Body Mass IndexCross-Sectional StudiesFemaleHumansMaleMiddle AgedNeckRacial GroupsRisk FactorsSeverity of Illness IndexSex FactorsSleep Apnea, ObstructiveWaist CircumferenceanthropometryethnicityMallampati scoreobesityobstructive sleep apnea

Identifiers

PMID30952214
PMCPMC6457518
OpenAlexW2938530255

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.