ArticleMolecular biology and evolution2019
Ancestry-Specific Analyses Reveal Differential Demographic Histories and Opposite Selective Pressures in Modern South Asian Populations.
Article in Molecular biology and evolution, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed.
- Layers in the sand: The genetic imprint of migration, culture, and Indus craft in the Thar Desert.HGG advances · 2026Article
- The Persian plateau served as hub for Homo sapiens after the main out of Africa dispersal.Nature communications · 2024Article
- Cross-continental admixture in the Kho population from northwest Pakistan.European journal of human genetics : EJHG · 2022Article
- The genomic signatures of natural selection in admixed human populations.American journal of human genetics · 2022Article
- Genetic Connections and Convergent Evolution of Tropical Indigenous Peoples in Asia.Molecular biology and evolution · 2022Article
- Contrasting maternal and paternal genetic histories among five ethnic groups from Khyber Pakhtunkhwa, Pakistan.Scientific reports · 2022Article
- Evaluation of Personalized Skincare Through in-silico Gene Interactive Networks and Cellular Responses to UVR and Oxidative Stress.Clinical, cosmetic and investigational dermatology · 2022Article
- Continental-scale genomic analysis suggests shared post-admixture adaptation in the Americas.Human molecular genetics · 2021Article
- Improving Selection Detection with Population Branch Statistic on Admixed Populations.Genome biology and evolution · 2021Article
- A Chromosome-Painting-Based Pipeline to Infer Local Ancestry under Limited Source Availability.Genome biology and evolution · 2021Article
- Systematic Review on Local Ancestor Inference From a Mathematical and Algorithmic Perspective.Frontiers in genetics · 2021Review
- Positive selection in admixed populations from Ethiopia.BMC genetics · 2020Article
- West Asian sources of the Eurasian component in Ethiopians: a reassessment.Scientific reports · 2019Article
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9 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Genetic variation in contemporary South Asian populations follows a northwest to southeast decreasing cline of shared West Eurasian ancestry. A growing body of ancient DNA evidence is being used to build increasingly more realistic models of demographic changes in the last few thousand years. Through high-quality modern genomes, these models can be tested for gene and genome level deviations. Using local ancestry deconvolution and masking, we reconstructed population-specific surrogates of the two main ancestral components for more than 500 samples from 25 South Asian populations and showed our approach to be robust via coalescent simulations. Our f3 and f4 statistics-based estimates reveal that the reconstructed haplotypes are good proxies for the source populations that admixed in the area and point to complex interpopulation relationships within the West Eurasian component, compatible with multiple waves of arrival, as opposed to a simpler one wave scenario. Our approach also provides reliable local haplotypes for future downstream analyses. As one such example, the local ancestry deconvolution in South Asians reveals opposite selective pressures on two pigmentation genes (SLC45A2 and SLC24A5) that are common or fixed in West Eurasians, suggesting post-admixture purifying and positive selection signals, respectively.
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