Evidence map›Paper›PMID 30952157›Full record

ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2019

White matter microstructure is associated with hyperactive/inattentive symptomatology and polygenic risk for attention-deficit/hyperactivity disorder in a population-based sample of adolescents.

Matthew D Albaugh, James J Hudziak, Alex Ing, Bader Chaarani, Edward Barker, Tianye Jia, Herve Lemaitre, Richard Watts, Catherine Orr, Philip A Spechler and 28 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.

  1. Pooled it
  2. Polygenic Scores for ADHD: A Meta-Analysis.Research on child and adolescent psychopathology · 2021
    Pooled it
  3. Article
  4. Article
  5. Research progress of tDCS in the treatment of ADHD.Journal of neural transmission (Vienna, Austria : 1996) · 2025
    Review
  6. Article
  7. Article
  8. Attention-deficit/hyperactivity disorder.Nature reviews. Disease primers · 2024
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. The structural connectome in ADHD.Psychoradiology · 2021
    Review
  17. Review
  18. Review
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

38 authors at 16 institutions in 6 countries.

Matthew D AlbaughDepartment of Psychiatry, Vermont Center for Children, Youth, and Families, University of Vermont College of Medicine, Burlington, VT, USA. malbaugh@uvm.edu.
James J HudziakDepartment of Psychiatry, Vermont Center for Children, Youth, and Families, University of Vermont College of Medicine, Burlington, VT, USA.
Alex IngMedical Research Council - Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Bader ChaaraniDepartment of Psychiatry, University of Vermont College of Medicine, Burlington, VT, USA.
Edward BarkerMedical Research Council - Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Tianye JiaMedical Research Council - Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0001-5399-2953
Herve LemaitreInstitut National de la Santé et de la Recherche Médicale, UMR 992 INSERM, CEA, Faculté de médecine, Université Paris-Sud, Université Paris-Saclay, NeuroSpin, F-91191, Gif-sur-Yvette, France.ORCID http://orcid.org/0000-0002-5952-076X
Richard WattsDepartment of Psychiatry, University of Vermont College of Medicine, Burlington, VT, USA.
Catherine OrrDepartment of Psychiatry, University of Vermont College of Medicine, Burlington, VT, USA.
Philip A SpechlerDepartment of Psychiatry, University of Vermont College of Medicine, Burlington, VT, USA.
Claude LepageMcConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, QC, Canada.
Vladimir FonovMcConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, QC, Canada.
Louis CollinsMcConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, QC, Canada.
Pierre RiouxMcConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, QC, Canada.
Alan C EvansMcConnell Brain Imaging Centre, Montreal Neurological Institute, McGill University, Montreal, QC, Canada.
Tobias BanaschewskiDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, 68159, Mannheim, Germany.
Arun L W BokdeDiscipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland.
Uli BrombergUniversity Medical Centre Hamburg-Eppendorf, House W34, 3.OG, Martinistrasse 52, 20246, Hamburg, Germany.ORCID http://orcid.org/0000-0003-4974-971X
Christian BüchelUniversity Medical Centre Hamburg-Eppendorf, House W34, 3.OG, Martinistrasse 52, 20246, Hamburg, Germany.
Erin Burke QuinlanMedical Research Council - Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Sylvane DesrivièresMedical Research Council - Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0002-9120-7060
Herta FlorDepartment of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, Mannheim, Germany.
Vincent FrouinNeuroSpin, CEA, Université Paris-Saclay, 91191, Gif-sur-Yvette, France.ORCID http://orcid.org/0000-0001-9360-6623
Penny GowlandSir Peter Mansfield Imaging Centre School of Physics and Astronomy, University of Nottingham, University Park, Nottingham, UK.
Andreas HeinzCharité - Universitätsmedizin Berlin, Department of Psychiatry and Psychotherapy, Campus Charité Mitte, Charitéplatz 1, Berlin, Germany.
Bernd IttermannPhysikalisch-Technische Bundesanstalt (PTB), Abbestrasse 2 - 12, Berlin, Germany.
Jean-Luc MartinotInstitut National de la Santé et de la Recherche Médicale, INSERM Unit 1000 "Neuroimaging & Psychiatry", University Paris Sud, University Paris Descartes - Sorbonne Paris Cité; and Maison de Solenn, Paris, France.
Frauke NeesDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Square J5, 68159, Mannheim, Germany.
Dimitri Papadopoulos OrfanosNeuroSpin, CEA, Université Paris-Saclay, 91191, Gif-sur-Yvette, France.ORCID http://orcid.org/0000-0002-1242-8990
Tomáš PausBloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital and Departments of Psychology and Psychiatry, University of Toronto, Toronto, ON, M6A 2E1, Canada.
Luise PoustkaDepartment of Child and Adolescent Psychiatry and Psychotherapy, University Medical Centre Göttingen, von-Siebold-Strasse 5, 37075, Göttingen, Germany.
Juliane H FröhnerDepartment of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, Germany.
Michael N SmolkaDepartment of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, Germany.ORCID http://orcid.org/0000-0001-5398-5569
Henrik WalterNeuroSpin, CEA, Université Paris-Saclay, 91191, Gif-sur-Yvette, France.ORCID http://orcid.org/0000-0002-9403-6121
Robert WhelanSchool of Psychology and Global Brain Health Institute, Trinity College Dublin, Dublin, Ireland.
Gunter SchumannMedical Research Council - Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Hugh GaravanDepartment of Psychiatry, University of Vermont College of Medicine, Burlington, VT, USA.
Alexandra PotterDepartment of Psychiatry, University of Vermont College of Medicine, Burlington, VT, USA.ORCID http://orcid.org/0000-0001-5813-6259
University of Vermont · USKing's College London · GBMontreal Neurological Institute and Hospital · CACommissariat à l'Énergie Atomique et aux Énergies Alternatives · FRHeidelberg University · DETechnische Universität Dresden · DETrinity College Dublin · IEUniversität Hamburg · DECharité - Universitätsmedizin Berlin · DEDélégation Paris 5 · FRHolland Bloorview Kids Rehabilitation Hospital · CAPhysikalisch-Technische Bundesanstalt · DEUniversité Paris-Sud · FRUniversity of Göttingen · DEUniversity of Mannheim · DEUniversity of Nottingham · GB

Funding

Medical Research Council MR/N000390/1Medical Research Council MR/N027558/1Medical Research Council MR/R00465X/1MRF_ MRF-058-0004-RG-DESRINIMH NIH HHS L40 MH108486
6 · The paper itself

Abstract

Few studies have investigated the link between putative biomarkers of attention-deficit/hyperactivity disorder (ADHD) symptomatology and genetic risk for ADHD. To address this, we investigate the degree to which ADHD symptomatology is associated with white matter microstructure and cerebral cortical thickness in a large population-based sample of adolescents. Critically, we then test the extent to which multimodal correlates of ADHD symptomatology are related to ADHD polygenic risk score (PRS). Neuroimaging, genetic, and behavioral data were obtained from the IMAGEN study. A dimensional ADHD composite score was derived from multi-informant ratings of ADHD symptomatology. Using tract-based spatial statistics, whole brain voxel-wise regressions between fractional anisotropy (FA) and ADHD composite score were calculated. Local cortical thickness was regressed on ADHD composite score. ADHD PRS was based on a very recent genome-wide association study, and calculated using PRSice. ADHD composite score was negatively associated with FA in several white matter pathways, including bilateral superior and inferior longitudinal fasciculi (p < 0.05, corrected). ADHD composite score was negatively associated with orbitofrontal cortical thickness (p < 0.05, corrected). The ADHD composite score was correlated with ADHD PRS (p < 0.001). FA correlates of ADHD symptomatology were significantly associated with ADHD PRS, whereas cortical thickness correlates of ADHD symptomatology were unrelated to ADHD PRS. Variation in hyperactive/inattentive symptomatology was associated with white matter microstructure, which, in turn, was related to ADHD PRS. Results suggest that genetic risk for ADHD symptomatology may be tied to biological processes affecting white matter microstructure.

Indexed as

AdolescentAnisotropyAttentionAttention Deficit Disorder with HyperactivityBrainCerebral CortexChildFemaleHumansMaleMultifactorial InheritanceNeural PathwaysOrgan SizePrefrontal CortexRisk AssessmentWhite Matter

Identifiers

PMID30952157
PMCPMC6784993
OpenAlexW2933447091

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.