Evidence map›Paper›PMID 30952156›Full record

ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2019

Withdrawal from escalated cocaine self-administration impairs reversal learning by disrupting the effects of negative feedback on reward exploitation: a behavioral and computational analysis.

Peter Zhukovsky, Mickael Puaud, Bianca Jupp, Júlia Sala-Bayo, Johan Alsiö, Jing Xia, Lydia Searle, Zoe Morris, Aryan Sabir, Chiara Giuliano and 4 more

Erratum issuedOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 37 citations in OpenAlex.

  1. Trial
  2. Orbitofrontal noradrenaline supports adaptive learning-rate adjustment in probabilistic reversal learning.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. From Computation to Clinic.Biological psychiatry global open science · 2023
    Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Prior Cocaine Use Alters the Normal Evolution of Information Coding in Striatal Ensembles during Value-Guided Decision-Making.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021
    Article
  16. Midbrain DBiological psychiatry · 2020
    Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Peter ZhukovskyDepartment of Psychology, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK.
Mickael PuaudDepartment of Psychology, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK.
Bianca JuppDepartment of Psychology, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK.
Júlia Sala-BayoDepartment of Psychology, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK.
Johan AlsiöDepartment of Psychology, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK.
Jing XiaDepartment of Psychology, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK.
Lydia SearleDepartment of Psychology, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK.
Zoe MorrisDepartment of Psychology, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK.
Aryan SabirDepartment of Psychology, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK.
Chiara GiulianoDepartment of Psychology, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK.
Barry J EverittDepartment of Psychology, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK.
David BelinDepartment of Psychology, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK.ORCID http://orcid.org/0000-0002-7383-372X
Trevor W RobbinsDepartment of Psychology, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK.
Jeffrey W DalleyDepartment of Psychology, University of Cambridge, Downing Street, Cambridge, CB2 3EB, UK. jwd20@cam.ac.uk.
University of Cambridge · GB

Funding

Medical Research Council G0001354Medical Research Council G1000183Medical Research Council G1002231Medical Research Council MR/N02530X/1Wellcome Trust
6 · The paper itself

Abstract

Addiction is regarded as a disorder of inflexible choice with behavior dominated by immediate positive rewards over longer-term negative outcomes. However, the psychological mechanisms underlying the effects of self-administered drugs on behavioral flexibility are not well understood. To investigate whether drug exposure causes asymmetric effects on positive and negative outcomes we used a reversal learning procedure to assess how reward contingencies are utilized to guide behavior in rats previously exposed to intravenous cocaine self-administration (SA). Twenty-four rats were screened for anxiety in an open field prior to acquisition of cocaine SA over six daily sessions with subsequent long-access cocaine SA for 7 days. Control rats (n = 24) were trained to lever-press for food under a yoked schedule of reinforcement. Higher rates of cocaine SA were predicted by increased anxiety and preceded impaired reversal learning, expressed by a decrease in lose-shift as opposed to win-stay probability. A model-free reinforcement learning algorithm revealed that rats with high, but not low cocaine escalation failed to exploit previous reward learning and were more likely to repeat the same response as the previous trial. Eight-day withdrawal from high cocaine escalation was associated, respectively, with increased and decreased dopamine receptor D2 (DRD2) and serotonin receptor 2C (HTR2C) expression in the ventral striatum compared with controls. Dopamine receptor D1 (DRD1) expression was also significantly reduced in the orbitofrontal cortex of high cocaine-escalating rats. These findings indicate that withdrawal from escalated cocaine SA disrupts how negative feedback is used to guide goal-directed behavior for natural reinforcers and that trait anxiety may be a latent variable underlying this interaction.

Indexed as

RewardAnimalsCocaineConditioning, OperantDrug-Seeking BehaviorMaleModels, NeurologicalPrefrontal CortexRatsReceptors, Dopamine D1Receptors, Dopamine D2Receptors, Serotonin, 5-HT2Reversal LearningVentral StriatumCocaineReceptors, Dopamine D1Receptors, Dopamine D2Receptors, Serotonin, 5-HT2

Identifiers

PMID30952156
PMCPMC6895115
OpenAlexW2930709511

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.