Evidence map›Paper›PMID 30952038›Full record

ArticleMedical image analysis2019

A modality-adaptive method for segmenting brain tumors and organs-at-risk in radiation therapy planning.

Mikael Agn, Per Munck Af Rosenschöld, Oula Puonti, Michael J Lundemann, Laura Mancini, Anastasia Papadaki, Steffi Thust, John Ashburner, Ian Law, Koen Van Leemput

Abstract read
In one paragraph

Article in Medical image analysis, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Article
  2. Review
  3. Synthetic data in generalizable, learning-based neuroimaging.Imaging neuroscience (Cambridge, Mass.) · 2024
    Article
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  13. Analyzing magnetic resonance imaging data from glioma patients using deep learning.Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society · 2021
    Review
  14. Article
  15. Article
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  17. Article
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mikael AgnDepartment of Applied Mathematics and Computer Science, Technical University of Denmark, Denmark. Electronic address: miag@dtu.dk.
Per Munck Af RosenschöldRadiation Physics, Department of Hematology, Oncology and Radiation Physics, Skåne University Hospital, Lund, Sweden.
Oula PuontiDanish Research Centre for Magnetic Resonance, Copenhagen University Hospital Hvidovre, Denmark.
Michael J LundemannDepartment of Oncology, Copenhagen University Hospital Rigshospitalet, Denmark.
Laura ManciniNeuroradiological Academic Unit, Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, University College London, UK; Lysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery, UCLH NHS Foundation Trust, UK.
Anastasia PapadakiNeuroradiological Academic Unit, Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, University College London, UK; Lysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery, UCLH NHS Foundation Trust, UK.
Steffi ThustNeuroradiological Academic Unit, Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, University College London, UK; Lysholm Department of Neuroradiology, National Hospital for Neurology and Neurosurgery, UCLH NHS Foundation Trust, UK.
John AshburnerWellcome Centre for Human Neuroimaging, UCL Institute of Neurology, University College London, UK.
Ian LawDepartment of Clinical Physiology, Nuclear Medicine and PET, Copenhagen University Hospital Rigshospitalet, Denmark.
Koen Van LeemputDepartment of Applied Mathematics and Computer Science, Technical University of Denmark, Denmark; Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, USA.

Funding

ULTRAHIGH FIELD TECHNOLOGY FOR FUNCTIONAL IMAGINGP41RR014075 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI ROSEN, BRUCE R · 1999 to 2011
$16.4M
Automated Segmentation of Subregions of the Medial Temporal Lobe in in vivo MRIR01EB013565 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI VAN LEEMPUT, KOEN · 2011 to 2014
$1.9M
SILICON GRAPHICS PRISM EXTREME 128P/1TBS10RR023043 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI SORENSEN, ALMA GREGORY · 2006 to 2006
$1.5M
NCRR NIH HHS P41 RR014075NCRR NIH HHS S10 RR023043NIBIB NIH HHS R01 EB013565Wellcome Trust
6 · The paper itself

Abstract

In this paper we present a method for simultaneously segmenting brain tumors and an extensive set of organs-at-risk for radiation therapy planning of glioblastomas. The method combines a contrast-adaptive generative model for whole-brain segmentation with a new spatial regularization model of tumor shape using convolutional restricted Boltzmann machines. We demonstrate experimentally that the method is able to adapt to image acquisitions that differ substantially from any available training data, ensuring its applicability across treatment sites; that its tumor segmentation accuracy is comparable to that of the current state of the art; and that it captures most organs-at-risk sufficiently well for radiation therapy planning purposes. The proposed method may be a valuable step towards automating the delineation of brain tumors and organs-at-risk in glioblastoma patients undergoing radiation therapy.

Indexed as

Magnetic Resonance ImagingNeural Networks, ComputerRadiotherapy Planning, Computer-AssistedBrain NeoplasmsGlioblastomaHumansImage Processing, Computer-AssistedOrgans at RiskGenerative probabilistic modelGliomaRestricted Boltzmann machineWhole-brain segmentation

Identifiers

PMID30952038
PMCPMC6554451

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.