Evidence map›Paper›PMID 30951834›Full record

ReviewMethods (San Diego, Calif.)2019

How to benchmark RNA secondary structure prediction accuracy.

David H Mathews

Abstract readReview
In one paragraph

Review in Methods (San Diego, Calif.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed.

  1. Markov models of SHAPE data improve secondary structure prediction.bioRxiv : the preprint server for biology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

David H MathewsCenter for RNA Biology, Department of Biochemistry & Biophysics, and Department of Biostatistics & Computational Biology, University of Rochester Medical Center, 601 Elmwood Avenue, Box 712, Rochester, NY 14642, United States. Electronic address: David_Mathews@urmc.rochester.edu.

Funding

Supporting RNAstructure: Software for RNA AnalysisR01GM076485 · NIGMS · UNIVERSITY OF ROCHESTER · PI MATHEWS, DAVID H. · 2006 to 2021
$4.7M
NIGMS NIH HHS R01 GM076485
6 · The paper itself

Abstract

RNA secondary structure prediction is widely used. As new methods are developed, these are often benchmarked for accuracy against existing methods. This review discusses good practices for performing these benchmarks, including the choice of benchmarking structures, metrics to quantify accuracy, the importance of allowing flexibility for pairs in the accepted structure, and the importance of statistical testing for significance.

Indexed as

Nucleic Acid ConformationAlgorithmsComputational BiologyRNASequence Analysis, RNASoftwareRNAComparative sequence analysisRNA folding

Identifiers

PMID30951834
PMCPMC7202366

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.