ArticleMechanisms of ageing and development2019
High intensity interval training improves physical performance in aged female mice: A comparison of mouse frailty assessment tools.
Article in Mechanisms of ageing and development, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07253714 (THE EFFECT OF PROPRIOCEPTIVE EXERCISE TRAINING ON CERVICAL PROPRIOCEPTION, KINESIOPHOBIA, AND PAIN CATASTROPHIZING LEVELS IN SARCOPENIC GERIATRIC INDIVIDUALS RESIDING IN NURSING HOMES), which is not on this map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The effect of proprioceptive exercise training on cervical proprioception, kinesiophobia, and pain catastrophizing levels in sarcopenic geriatric individuals residing in nursing homes
Who cites it
19 citing papers in PubMed, 32 citations in OpenAlex.
- High-intensity interval training in aged female mice preserves physical, cognitive, and cardiovascular function.GeroScience · 2026Article
- Effect of high-intensity interval training and resistance training on the follistatin and myostatin levels in gastrocnemius muscle of aged female rats.Biogerontology · 2025Article
- Article
- Provocative testing in community dwelling older adults: a path to identify physical resilience.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Evaluating frailty assessment tools and biological frailty markers in C57BL/6 female mice.GeroScience · 2025Article
- A Narrative Review Evaluating Diet and Exercise as Complementary Medicine for the Management of Alzheimer's Disease.Nutrients · 2025Review
- Editorial: Clinical uses and alternative approaches of frailty determination.Frontiers in physiology · 2025Article
- Effects of high-intensity interval training on physical and cognitive function in middle-aged male mice.Frontiers in aging · 2025Article
- Comprehensive longitudinal non-invasive quantification of healthspan and frailty in a large cohort (n = 546) of geriatric C57BL/6 J mice.GeroScience · 2023Article
- Impact of Diet and Exercise Interventions on Cognition and Brain Health in Older Adults: A Narrative Review.Nutrients · 2023Review
- Exercise and Exercise Mimetics for the Treatment of Musculoskeletal Disorders.Current osteoporosis reports · 2022Review
- Animal Models of Exercise From Rodents to Pythons.Circulation research · 2022Review
- Physiological Systems in Promoting Frailty.Comprehensive Physiology · 2022Review
- Aerobic Exercise Attenuates Frailty in Aging Male and Female C57Bl/6 Mice and Effects Systemic Cytokines Differentially by Sex.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
- Alteration of skeletal and cardiac muscles function inIntractable & rare diseases research · 2021Article
- The degree of frailty as a translational measure of health in aging.Nature aging · 2021Review
- Pinpointing a Role for Vitamin D in Frailty: A Time for Animal Models?Advances in geriatric medicine and research · 2021Article
- Vitamin D Insufficiency Reduces Grip Strength, Grip Endurance and Increases Frailty in Aged C57Bl/6J Mice.Nutrients · 2020Article
- Short-term nicotinamide riboside treatment improves muscle quality and function in mice and increases cellular energetics and differentiating capacity of myogenic progenitors.Nutrition (Burbank, Los Angeles County, Calif.)Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Frailty syndrome increases the risk for disability and mortality, and is a major health concern amidst the geriatric shift in the population. High intensity interval training (HIIT), which couples bursts of vigorous activity interspersed with active recovery intervals, shows promise for the treatment of frailty. Here we compare and contrast five Fried physical phenotype and one deficit accumulation based mouse frailty assessment tools for identifying the impacts of HIIT on frailty and predicting functional capacity, underlying pathology, and survival in aged female mice. Our data reveal a 10-minute HIIT regimen administered 3-days-a-week for 8-weeks increased treadmill endurance, gait speed and maintained grip strength. One frailty tool identified a benefit of HIIT for frailty, but many were trending suggesting HIIT was beneficial for physical performance in these mice, but the 8-week timeframe may have been insufficient to induce frailty benefits. Finally, most frailty tools distinguished between surviving or non-surviving mice, whereas half correlated with functional capacity measured by nest building ability, and none correlated with underlying pathology. In summary, this study supports the ongoing development of mouse assessment tools as useful instruments for frailty research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.