Evidence map›Paper›PMID 30951672›Full record

ArticleCell2019

exRNA Atlas Analysis Reveals Distinct Extracellular RNA Cargo Types and Their Carriers Present across Human Biofluids.

Oscar D Murillo, William Thistlethwaite, Joel Rozowsky, Sai Lakshmi Subramanian, Rocco Lucero, Neethu Shah, Andrew R Jackson, Srimeenakshi Srinivasan, Allen Chung, Clara D Laurent and 48 more

Abstract readDataset
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 210 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
210citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

210 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
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  12. The Common Fund Data Ecosystem (CFDE).bioRxiv : the preprint server for biology · 2026
    Article
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  15. Article
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  17. Article
  18. Exosomes in ocular graft-versus-host disease: an overview.International journal of ophthalmology · 2026
    Review
  19. Article
  20. Article

150 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

58 authors.

Oscar D MurilloDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
William ThistlethwaiteDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
Joel RozowskyDepartment of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA.
Sai Lakshmi SubramanianDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
Rocco LuceroDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
Neethu ShahDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
Andrew R JacksonDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
Srimeenakshi SrinivasanDepartment of Obstetrics, Gynecology, and Reproductive Sciences and Sanford Consortium for Regenerative Medicine, University of California, San Diego, La Jolla, CA 92037, USA.
Allen ChungDepartment of Surgery, University of California, San Francisco, San Francisco, CA 94143, USA; Surgical Service, San Francisco Veterans Affairs Medical Center, San Francisco, CA 94121, USA.
Clara D LaurentDepartment of Obstetrics, Gynecology, and Reproductive Sciences and Sanford Consortium for Regenerative Medicine, University of California, San Diego, La Jolla, CA 92037, USA.
Robert R KitchenExosome Diagnostics, Inc., Waltham, MA 02451, USA.
Timur GaleevDepartment of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA.
Jonathan WarrellDepartment of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA.
James A DiaoDepartment of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA; Harvard-MIT Division of Health Sciences and Technology, Harvard Medical School, Boston, MA 02115, USA.
Joshua A WelshTranslational Nanobiology Section, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Kristina HanspersGladstone Institutes, San Francisco, CA 94158, USA.
Anders RiuttaGladstone Institutes, San Francisco, CA 94158, USA.
Sebastian Burgstaller-MuehlbacherDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Ravi V ShahCardiovascular Research Center, Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Ashish YeriCardiovascular Research Center, Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Lisa M JenkinsLaboratory of Cell Biology, Center for Cancer Research, NIH, Bethesda, MD 20892, USA.
Mehmet E AhsenDepartment of Genetics and Genomics Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Carlos Cordon-CardoDepartment of Pathology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Navneet DograDepartment of Genetics and Genomics Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; IBM T.J. Watson Research Center, IBM Research, Yorktown Heights, NY 10598, USA.
Stacey M GiffordIBM T.J. Watson Research Center, IBM Research, Yorktown Heights, NY 10598, USA.
Joshua T SmithIBM T.J. Watson Research Center, IBM Research, Yorktown Heights, NY 10598, USA.
Gustavo StolovitzkyDepartment of Genetics and Genomics Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; IBM T.J. Watson Research Center, IBM Research, Yorktown Heights, NY 10598, USA.
Ashutosh K TewariDepartment of Urology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Benjamin H WunschIBM T.J. Watson Research Center, IBM Research, Yorktown Heights, NY 10598, USA.
Kamlesh K YadavDepartment of Urology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Sema4, Stamford, CT 06902, USA.
Kirsty M DanielsonCardiovascular Research Center, Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Justyna FilantDepartment of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Courtney MoellerDepartment of Obstetrics, Gynecology, and Reproductive Sciences and Sanford Consortium for Regenerative Medicine, University of California, San Diego, La Jolla, CA 92037, USA.
Parham NejadDepartment of Neurology, Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Anu PaulDepartment of Neurology, Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Bridget SimonsonCardiovascular Research Center, Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
David K WongDepartment of Surgery, University of California, San Francisco, San Francisco, CA 94143, USA; Surgical Service, San Francisco Veterans Affairs Medical Center, San Francisco, CA 94121, USA.
Xuan ZhangExosome Diagnostics, Inc., Waltham, MA 02451, USA.
Leonora BalajDepartment of Neurosurgery, Massachusetts General Hospital, Boston, MA 02114, USA.
Roopali GandhiDepartment of Neurology, Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Anil K SoodDepartment of Gynecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Center for RNA Interference and Non-Coding RNAs, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Roger P AlexanderPacific Northwest Research Institute, Seattle, WA 98122, USA.
Liang WangDepartment of Pathology and MCW Cancer Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Chunlei WuDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
David T W WongSchool of Dentistry, University of California, Los Angeles, Los Angeles, CA 90095, USA.
David J GalasPacific Northwest Research Institute, Seattle, WA 98122, USA.
Kendall Van Keuren-JensenNeurogenomics, The Translational Genomics Research Institute (TGen), Phoenix, AZ 85004, USA.
Tushar PatelDepartment of Transplantation, Mayo Clinic, Jacksonville, FL 32224, USA.
Jennifer C JonesTranslational Nanobiology Section, Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Saumya DasCardiovascular Research Center, Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Kei-Hoi CheungDepartment of Emergency Medicine, Yale University School of Medicine, New Haven, CT 06520, USA.
Alexander R PicoGladstone Institutes, San Francisco, CA 94158, USA.
Andrew I SuDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Robert L RaffaiDepartment of Surgery, University of California, San Francisco, San Francisco, CA 94143, USA; Surgical Service, San Francisco Veterans Affairs Medical Center, San Francisco, CA 94121, USA.
Louise C LaurentDepartment of Obstetrics, Gynecology, and Reproductive Sciences and Sanford Consortium for Regenerative Medicine, University of California, San Diego, La Jolla, CA 92037, USA.
Matthew E RothDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
Mark B GersteinDepartment of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA; Program in Computational Biology & Bioinformatics, Yale University, New Haven, CT 06520, USA; Department of Computer Science, Yale University, New Haven, CT 06520, USA.
Aleksandar MilosavljevicDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address: amilosav@bcm.edu.

Funding

Research BaseP30DK063720 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GERMAN, MICHAEL S · 2003 to 2019
$21.8M
SOC CoreU54DA036134 · NIDA · BAYLOR COLLEGE OF MEDICINE · PI GALAS, DAVID J., GERSTEIN, MARK BENDER · 2013 to 2018
$15.0M
Initiative for Maximizing Student Development (IMSD) ProgramR25GM056929 · NIGMS · BAYLOR COLLEGE OF MEDICINE · PI PEREIRA, FRED A · 1998 to 2023
$12.4M
Development and use of nanoFACS for analysis and sorting of nanoparticlesZIABC011502 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI JONES, JENNIFER · 2013 to 2025
$8.6M
U.T. M. D. Anderson Cancer Center SPORE in Ovarian CancerP50CA217685 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI BAST, ROBERT C, SOOD, ANIL K · 2017 to 2021
$7.9M
Transcellular epigenetic regulation by ex-small RNA in C. elegantU19CA179512 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BLELLOCH, ROBERT · 2013 to 2017
$7.4M
PROGRAM IN HUMAN MOLECULAR GENETICST32GM008307 · NIGMS · BAYLOR COLLEGE OF MEDICINE · PI SHAULSKY, GAD · 1990 to 2020
$6.6M
Harnessing the power of exosomes for non-coding RNA deliveryR35CA209904 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI SOOD, ANIL K · 2017 to 2023
$5.0M
Reference Profiles of ExRNAs in Normal Human PregnancyU01HL126494 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LAURENT, LOUISE CHANG · 2014 to 2018
$3.4M
Plasma miRNA predictors of adverse mechanical and electrical remodeling after MIUH3TR000901 · NCATS · MASSACHUSETTS GENERAL HOSPITAL · PI DAS, SAUMYA, KWONG, RAYMOND Y · 2015 to 2017
$3.2M
Novel extra cellular RNA-based combinatorial RNA inhibition therapyUH3TR000943 · NCATS · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI CALIN, GEORGE A., LOPEZ-BERESTEIN, GABRIEL · 2015 to 2017
$3.2M
Implications of metabolism on healthy aging in African and Caucasian Americans: the Health ABC studyR01AG059729 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MURTHY, VENKATESH LOCHARLA, NEWMAN, ANNE B. · 2018 to 2022
$3.1M
NCATS NIH HHS UH2 TR000901NCATS NIH HHS UH2 TR000906NCATS NIH HHS UH2 TR000923NCATS NIH HHS UH3 TR000891NCATS NIH HHS UH3 TR000901NCATS NIH HHS UH3 TR000906NCATS NIH HHS UH3 TR000923NCATS NIH HHS UH3 TR000943NCI NIH HHS P50 CA217685NCI NIH HHS R01 CA163849NCI NIH HHS R35 CA209904NCI NIH HHS U19 CA179512NHLBI NIH HHS K23 HL127099NHLBI NIH HHS R01 HL122547NHLBI NIH HHS R01 HL133575NHLBI NIH HHS R01 HL136685NHLBI NIH HHS U01 HL126494NIA NIH HHS R01 AG059729NIDA NIH HHS U54 DA036134NIDDK NIH HHS P30 DK063720NIGMS NIH HHS R25 GM056929NIGMS NIH HHS T32 GM008307
6 · The paper itself

Abstract

To develop a map of cell-cell communication mediated by extracellular RNA (exRNA), the NIH Extracellular RNA Communication Consortium created the exRNA Atlas resource (https://exrna-atlas.org). The Atlas version 4P1 hosts 5,309 exRNA-seq and exRNA qPCR profiles from 19 studies and a suite of analysis and visualization tools. To analyze variation between profiles, we apply computational deconvolution. The analysis leads to a model with six exRNA cargo types (CT1, CT2, CT3A, CT3B, CT3C, CT4), each detectable in multiple biofluids (serum, plasma, CSF, saliva, urine). Five of the cargo types associate with known vesicular and non-vesicular (lipoprotein and ribonucleoprotein) exRNA carriers. To validate utility of this model, we re-analyze an exercise response study by deconvolution to identify physiologically relevant response pathways that were not detected previously. To enable wide application of this model, as part of the exRNA Atlas resource, we provide tools for deconvolution and analysis of user-provided case-control studies.

Indexed as

AdultBody FluidsCell CommunicationCell-Free Nucleic AcidsCirculating MicroRNAExtracellular VesiclesFemaleHumansMaleReproducibility of ResultsRNASequence Analysis, RNASoftwareCell-Free Nucleic AcidsCirculating MicroRNARNAdeconvolutionERCCexosomesexRNAextracellular RNAextracellular vesicleslipoproteinsribonucleoproteins

Identifiers

PMID30951672
PMCPMC6616370

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.