ArticleCell2019
Structure of Microbial Nanowires Reveals Stacked Hemes that Transport Electrons over Micrometers.
Article in Cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 201 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
201 citing papers in PubMed, 558 citations in OpenAlex.
- Electroactive Microbiomes: Electron Transfer Mechanisms and Environmental Biotechnology Applications.Environmental microbiology reports · 2026Review
- Overview of pathways and dynamic interactions of c-type cytochromes in Geobacter sulfurreducens.Biochemical Society transactions · 2026Review
- Model Structures and Electron Transfer Properties of Conductive Nickel-Organic Nanoribbons in Cable Bacteria.The journal of physical chemistry letters · 2026Article
- Highly efficient long-range conduction through a biosynthetic nickel-organic framework.Nature communications · 2026Article
- Heme handling in the system II heme lyase CcsBA from Bacteroides thetaiotaomicron.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2026Article
- Quantifying the Sequence-Dependent Kinetic Protection of Reduced Heme in Peptide Amphiphile Nanofibers.The journal of physical chemistry. B · 2026Article
- Silicate-bound iron drives abiotic solar energy conversion in terrestrial environments.Nature communications · 2026Article
- Inspiration from humans and microbes-and maybe a lot of luck: the "discovery" ofJournal of bacteriology · 2026Review
- Environmental considerations and bioremediation applications of the metal-, nitrate-, and organohalide-respiring bacteriumApplied and environmental microbiology · 2026Review
- To Biotic or Abiotic: Biohybrid Systems for Artificial Photosynthesis.Chemical reviews · 2026Review
- Bioelectrode Healing via Engineered Electrode Reconstruction on Biofilms under Strong Acid and Ultrahigh Current Density.Chem & bio engineering · 2026Article
- Synthesis and biophysical characterization of bioengineered cytochrome nanowires.European biophysics journal : EBJ · 2026Article
- Solvent Environment Influences Molecular Conformation and Electron Transport in Peptides.The journal of physical chemistry letters · 2026Article
- Ghost-rocks' microbiota: metagenomic insights into their influence on the biogeochemistry of karstic cave and groundwater.FEMS microbiology ecology · 2026Article
- Designing Microbe-Semiconductor Interfaces for Semibiological Photosynthesis.Chemical reviews · 2026Review
- Sources of non-Arrhenius electron transport in bacterial nanowires.Physical chemistry chemical physics : PCCP · 2026Article
- Genome-centric metagenomics reveals electroactive syntrophs in a conductive particle-dependent consortium from coastal sediments.Nature communications · 2026Article
- Article
- Living Photoanodes for Solar-Driven Water Oxidation.Chemical reviews · 2026Review
- From single step hops to emergent biological phenomena.Journal of inorganic biochemistry · 2026Review
141 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 3 institutions in 1 country.
Funding
Abstract
Long-range (>10 μm) transport of electrons along networks of Geobacter sulfurreducens protein filaments, known as microbial nanowires, has been invoked to explain a wide range of globally important redox phenomena. These nanowires were previously thought to be type IV pili composed of PilA protein. Here, we report a 3.7 Å resolution cryoelectron microscopy structure, which surprisingly reveals that, rather than PilA, G. sulfurreducens nanowires are assembled by micrometer-long polymerization of the hexaheme cytochrome OmcS, with hemes packed within ∼3.5-6 Å of each other. The inter-subunit interfaces show unique structural elements such as inter-subunit parallel-stacked hemes and axial coordination of heme by histidines from neighboring subunits. Wild-type OmcS filaments show 100-fold greater conductivity than other filaments from a ΔomcS strain, highlighting the importance of OmcS to conductivity in these nanowires. This structure explains the remarkable capacity of soil bacteria to transport electrons to remote electron acceptors for respiration and energy sharing.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.