ReviewCell2019
The Extracellular RNA Communication Consortium: Establishing Foundational Knowledge and Technologies for Extracellular RNA Research.
Abstract readReview
In one paragraph
Review in Cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 152 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
152citing papers in PubMed, 2 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
152 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Rethinking Alzheimer's: novel miRNAs illuminate a disease beyond the brain.Molecular psychiatry · 2026Pooled it
- Prognostic value of miR-21 in colorectal cancer, pancreatic ductal adenocarcinoma, and esophageal squamous cell carcinoma: updated systematic review and meta-analysis.The oncologist · 2025Pooled it
- Extracellular Vesicles and Their Role in Osteogenesis.Bioengineering (Basel, Switzerland) · 2026Review
- Tumour-Derived Extracellular Vesicles Containing dsRNA Induce Degradation of Ribosomal Protein mRNA in Platelets.Journal of extracellular vesicles · 2026Article
- GLP-1 agonists in neurodegeneration: a multimodal biomarker-guided approach.Trends in molecular medicine · 2026Review
- Emerging signal transduction pathways and the role of bacterial extracellular vesicles linked to the pathogenesis of endometriosis.Communications medicine · 2026Review
- Nanopore direct RNA sequencing and the epitranscriptome: Advances in mapping native RNA landscapes.iMeta · 2026Review
- Analytical Validation of NETest2.0Cancers · 2026Article
- Ion channel and biophysical properties of extracellular vesicles.The Journal of biological chemistry · 2026Review
- Liquid biopsy in the clinical management of tumor of urinary system: current status and future developments.Cellular oncology (Dordrecht, Netherlands) · 2026Review
- The Common Fund Data Ecosystem (CFDE).bioRxiv : the preprint server for biology · 2026Article
- Review
- Dysregulation of Extracellular Vesicle Concentration, MicroRNAs, and Surface Proteins in Patients With Niemann-Pick Disease Type C.Journal of extracellular biology · 2026Article
- Long noncoding RNA GAS5 disrupts intestinal epithelial barrier function by increasing small vault RNA levels.JCI insight · 2026Article
- Circulating RNA as a Functional Component of Liquid Biopsy in Cancer: Concepts, Classification, and Clinical Applications.International journal of molecular sciences · 2026Review
- Mutual regulation of spermatogenesis-specific Argonaute proteins and Insulin/IGF-1 signaling in aging control.EMBO reports · 2026Article
- The role of microRNAs in modulating Wnt signaling pathway dynamics and their therapeutic implications in non-small cell lung cancer.Discover oncology · 2026Review
- exoRBase 3.0: an updated resource for extracellular RNAs from human biofluids.Nucleic acids research · 2026Article
- Noncoding RNA in Clinical Trials: Diagnostic and Therapeutical Prospects.Experientia supplementum (2012) · 2026Review
- Extracellular Vesicles, Nutrient Balance, and Redox Metabolism During Epididymal Sperm Maturation: A Perspective on the Complexity of Intercellular Interplay.Advances in anatomy, embryology, and cell biology · 2026Review
92 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors.
Saumya DasCardiovascular Research Center, Massachusetts General Hospital, Boston, MA 02114, USA.
Extracellular RNA Communication Consortiumhttp://exRNA.org/.
K Mark AnselDepartment Microbiology & Immunology and Sandler Asthma Basic Research Center, University of California San Francisco, San Francisco, CA 94143, USA.
Markus BitzerDepartment of Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
Xandra O BreakefieldDepartment of Neurology and Center for Molecular Imaging Research Department of Radiology, Massachusetts General Hospital, Charlestown, MA 02129 USA; Program in Neuroscience, Harvard Medical School, Boston, MA 02115, USA.
Alain CharestDepartment of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
David J GalasPacific Northwest Research Institute, Seattle, WA 98122, USA.
Mark B GersteinProgram in Computational Biology & Bioinformatics, Department of Molecular Biophysics & Biochemistry, Department of Computer Science, and Department of Statistics & Data Science, Yale University, New Haven, CT 06520, USA.
Mihir GuptaDepartment of Neurosurgery, University of California, San Diego, CA 92093, USA.
Aleksandar MilosavljevicMolecular and Human Genetics Department, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA; Program in Quantitative and Computational Biosciences, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA.
Michael T McManusDepartment of Microbiology and Immunology, University of California San Francisco Diabetes Center, WM Keck Center for Noncoding RNAs, University of California, San Francisco, San Francisco, CA 94143, USA.
Tushar PatelDepartment of Transplantation, Mayo Clinic, Jacksonville, FL 32224, USA.
Robert L RaffaiDepartment of Surgery, University of California San Francisco & Veterans Affairs Medical Center San Francisco, San Francisco, CA 94121, USA.
Joel RozowskyDepartment of Molecular Biophysics and Biochemistry, Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT 06520, USA.
Matthew E RothMolecular and Human Genetics Department, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA; Program in Quantitative and Computational Biosciences, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA.
Julie A SaugstadDepartment of Anesthesiology & Perioperative Medicine, Oregon Health & Science University, Portland, OR 97239, USA.
Kendall Van Keuren-JensenNeurogenomics, Translational Genomics Research Institute, Phoenix, AZ 85284, USA.
Alissa M WeaverDepartment of Cell and Developmental Biology, Vanderbilt University School of Medicine and Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Louise C LaurentDepartment of Obstetrics, Gynecology, and Reproductive Sciences and Sanford Consortium for Regenerative Medicine, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address: llaurent@ucsd.edu.
Funding
The role of microvesicles in giloma virotherapyP01CA069246 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI BREAKEFIELD, XANDRA OWENS, CHIOCCA, E. ANTONIO · 1996 to 2021
$30.9MRegional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mehboob A Hussain · 2013 to 2026
$24.3MSOC CoreU54DA036134 · NIDA · BAYLOR COLLEGE OF MEDICINE · PI GALAS, DAVID J., GERSTEIN, MARK BENDER · 2013 to 2018
$15.0MTransfer of microRNA regulators from glioblastoma to brain microenvironment U19CA179563 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI BREAKEFIELD, XANDRA OWENS, CHAREST, ALAIN · 2013 to 2017
$8.6MSidTI/2-dependent EC-RNA Biogenesis and UptalceU19CA179513 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MCMANUS, MICHAEL T · 2013 to 2017
$8.3MTranscellular epigenetic regulation by ex-small RNA in C. elegantU19CA179512 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BLELLOCH, ROBERT · 2013 to 2017
$7.4MExRNA composition in SLE patients and factors influencing exRNP abundance and thU19CA179564 · NCI · ROCKEFELLER UNIVERSITY · PI TUSCHL, THOMAS · 2013 to 2017
$7.1MTrafficking of eRNAs in K-Ras Mutant Colon CancerU19CA179514 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI COFFEY, ROBERT J. · 2013 to 2017
$5.3MHYDROGEN IONS AND BRAIN INFARCTIONR01NS019108 · NINDS · WEILL MEDICAL COLLEGE OF CORNELL UNIV · PI KRAIG, RICHARD P · 1985 to 2019
$5.2MRegenerative Musculoskeletal Medicine Training ProgramT32AR059033 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI John S Adams, Nicholas M. Bernthal · 2011 to 2026
$4.8MReference Profiles of Extracellular RNA in 4 Body Fluids of Healthy HumansU01HL126496 · NHLBI · PACIFIC NORTHWEST RESEARCH INSTITUTE · PI GALAS, DAVID J., NICKERSON, DEBORAH A · 2014 to 2018
$3.5MDefining A Comprehensive Reference Profile of Circulating Human Extracellular RNAU01HL126493 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ERLE, DAVID J, WOODRUFF, PRESCOTT G · 2014 to 2018
$3.5MNCATS NIH HHS UH2 TR000875NCATS NIH HHS UH2 TR000880NCATS NIH HHS UH2 TR000884NCATS NIH HHS UH2 TR000888NCATS NIH HHS UH2 TR000890NCATS NIH HHS UH2 TR000891NCATS NIH HHS UH2 TR000901NCATS NIH HHS UH2 TR000902NCATS NIH HHS UH2 TR000903NCATS NIH HHS UH2 TR000906NCATS NIH HHS UH2 TR000914NCATS NIH HHS UH2 TR000918NCATS NIH HHS UH2 TR000921NCATS NIH HHS UH2 TR000923NCATS NIH HHS UH2 TR000928NCATS NIH HHS UH2 TR000931NCATS NIH HHS UH2 TR000933NCATS NIH HHS UH2 TR000943NCATS NIH HHS UH3 TR000875NCATS NIH HHS UH3 TR000884NCATS NIH HHS UH3 TR000888NCATS NIH HHS UH3 TR000890NCATS NIH HHS UH3 TR000891NCATS NIH HHS UH3 TR000901NCATS NIH HHS UH3 TR000902NCATS NIH HHS UH3 TR000903NCATS NIH HHS UH3 TR000906NCATS NIH HHS UH3 TR000914NCATS NIH HHS UH3 TR000918NCATS NIH HHS UH3 TR000921NCATS NIH HHS UH3 TR000923NCATS NIH HHS UH3 TR000928NCATS NIH HHS UH3 TR000931NCATS NIH HHS UH3 TR000933NCATS NIH HHS UH3 TR000943NCI NIH HHS P01 CA069246NCI NIH HHS U19 CA179512NCI NIH HHS U19 CA179513NCI NIH HHS U19 CA179514NCI NIH HHS U19 CA179563NCI NIH HHS U19 CA179564NHLBI NIH HHS K24 HL137013NHLBI NIH HHS R01 HL128996NHLBI NIH HHS R01 HL145721NHLBI NIH HHS U01 HL126493NHLBI NIH HHS U01 HL126494NHLBI NIH HHS U01 HL126495NHLBI NIH HHS U01 HL126496NHLBI NIH HHS U01 HL126497NHLBI NIH HHS U01 HL126499NIAMS NIH HHS T32 AR059033NIA NIH HHS R01 AG041232NIDA NIH HHS U54 DA036134NIDDK NIH HHS P30 DK020572NIDDK NIH HHS R01 DK100449NINDS NIH HHS R01 NS019108
Abstract
The Extracellular RNA Communication Consortium (ERCC) was launched to accelerate progress in the new field of extracellular RNA (exRNA) biology and to establish whether exRNAs and their carriers, including extracellular vesicles (EVs), can mediate intercellular communication and be utilized for clinical applications. Phase 1 of the ERCC focused on exRNA/EV biogenesis and function, discovery of exRNA biomarkers, development of exRNA/EV-based therapeutics, and construction of a robust set of reference exRNA profiles for a variety of biofluids. Here, we present progress by ERCC investigators in these areas, and we discuss collaborative projects directed at development of robust methods for EV/exRNA isolation and analysis and tools for sharing and computational analysis of exRNA profiling data.
Indexed as
BiomarkersCell-Free Nucleic AcidsExtracellular VesiclesHumansKnowledge BasesMicroRNAsRNABiomarkersCell-Free Nucleic AcidsMicroRNAsRNA
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.