Evidence map›Paper›PMID 30951661›Full record

ReviewCell stem cell2019

Polycomb/Trithorax Antagonism: Cellular Memory in Stem Cell Fate and Function.

Marjorie Brand, Kiran Nakka, Jiayu Zhu, F Jeffrey Dilworth

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cell stem cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Marjorie BrandSprott Center for Stem Cell Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada K1H 8L6; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada K1H 8L6. Electronic address: mbrand@ohri.ca.
Kiran NakkaSprott Center for Stem Cell Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada K1H 8L6; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada K1H 8L6.
Jiayu ZhuSprott Center for Stem Cell Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada K1H 8L6; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada K1H 8L6.
F Jeffrey DilworthSprott Center for Stem Cell Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada K1H 8L6; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada K1H 8L6. Electronic address: jdilworth@ohri.ca.

Funding

Transcriptional Control During ErythropoiesisR01DK098449 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI Marjorie Carole Brand, JEFFREY A RANISH · 2013 to 2026
$5.8M
CIHR 201503MOPCIHR 201708IGHCIHR 201709PJTCIHR FDN-143330NIDDK NIH HHS R01 DK098449
6 · The paper itself

Abstract

Stem cells are continuously challenged with the decision to either self-renew or adopt a new fate. Self-renewal is regulated by a system of cellular memory, which must be bypassed for differentiation. Previous studies have identified Polycomb group (PcG) and Trithorax group (TrxG) proteins as key modulators of cellular memory. In this Perspective, we draw from embryonic and adult stem cell studies to discuss the complex roles played by PcG and TrxG in maintaining cell identity while allowing for microenvironment-mediated alterations in cell fate. Finally, we discuss the potential for targeting these proteins as a therapeutic approach in cancer.

Indexed as

AnimalsHumansPolycomb-Group ProteinsStem CellsPolycomb-Group Proteinscell fatecellular memoryepigeneticsEzh2histone methylationleukemiaPolycombtranscription factorsTrithoraxUTX

Identifiers

PMID30951661
PMCPMC6866673

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.