Evidence map›Paper›PMID 30951657›Full record

ArticleCell stem cell2019

Stars in the Night Sky: iPSC-Cardiomyocytes Return the Patient Context to Drug Screening.

Anna Hnatiuk, Mark Mercola

Open access · bronzeAbstract readComment
PubMed Publisher
In one paragraph

Article in Cell stem cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Stem cells and lung regeneration.American journal of physiology. Cell physiology · 2020
    Review
  5. Article
  6. Application of iPSC to Modelling of Respiratory Diseases.Advances in experimental medicine and biology · 2020
    Review
  7. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Anna HnatiukStanford Cardiovascular Institute and Department of Medicine, Stanford University, 1651 Page Mill Road, Palo Alto, CA 94305, USA.
Mark MercolaStanford Cardiovascular Institute and Department of Medicine, Stanford University, 1651 Page Mill Road, Palo Alto, CA 94305, USA. Electronic address: mmercola@stanford.edu.
Cardiovascular Institute of the South · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

iPSC-derived cardiomyocytes have the potential to revolutionize the discovery of new medicines for serious heart conditions; however, heart failure remains a major cause of mortality worldwide. In this issue of Cell Stem Cell, Fiedler et al. (2019) describe using iPSC-derived cardiomyocytes to screen new chemical entities, discovering a small molecule for ischemic injury.

Indexed as

Induced Pluripotent Stem CellsMyocytes, CardiacCell DifferentiationDrug Evaluation, PreclinicalHumansInfarctionIntracellular Signaling Peptides and ProteinsProtein Serine-Threonine KinasesIntracellular Signaling Peptides and ProteinsMAP4K4 protein, humanProtein Serine-Threonine Kinases

Identifiers

PMID30951657
OpenAlexW2935636634

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.