Evidence map›Paper›PMID 30951614›Full record

ArticleJournal of surgical oncology2019

Preoperative risk evaluation for pancreatic fistula after pancreaticoduodenectomy.

Ryan J Ellis, D Brock Hewitt, Jason B Liu, Mark E Cohen, Ryan P Merkow, David J Bentrem, Karl Y Bilimoria, Anthony D Yang

Abstract readMulticenter Study
In one paragraph

Article in Journal of surgical oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. Trial
  2. Preoperative weight loss and postoperative pancreatic fistula risk affected by body mass index: a National Surgical Quality Improvement Program study.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2025
    Article
  3. Review
  4. Preoperative body composition measured by bioelectrical impedance analysis can predict pancreatic fistula after pancreatic surgery.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ryan J EllisDivision of Research and Optimal Patient Care, American College of Surgeons, Chicago, Illinois.
D Brock HewittDepartment of Surgery, Surgical Outcomes and Quality Improvement Center, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
Jason B LiuDivision of Research and Optimal Patient Care, American College of Surgeons, Chicago, Illinois.ORCID http://orcid.org/0000-0002-7083-5703
Mark E CohenDivision of Research and Optimal Patient Care, American College of Surgeons, Chicago, Illinois.
Ryan P MerkowDepartment of Surgery, Surgical Outcomes and Quality Improvement Center, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
David J BentremDepartment of Surgery, Surgical Outcomes and Quality Improvement Center, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
Karl Y BilimoriaDivision of Research and Optimal Patient Care, American College of Surgeons, Chicago, Illinois.
Anthony D YangDepartment of Surgery, Surgical Outcomes and Quality Improvement Center, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.ORCID http://orcid.org/0000-0002-9053-0974

Funding

Tailored Adaptation of the AHRQ VTE QI Guide to Local Hospital Context.K08HL145139 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI YANG, ANTHONY D. · 2019 to 2023
$800k
Agency for Healthcare Research and Quality 5T32HS000078AHRQ HHS T32 HS000078National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health K08HL145139NHLBI NIH HHS K08 HL145139
6 · The paper itself

Abstract

backgroundPancreatic fistula remains common, with limited ability to risk stratify patients preoperatively. The objective of this study was to identify risk factors for clinically-relevant postoperative pancreatic fistula (CR-POPF) that are routinely available in the preoperative setting.

methodsPreoperatively available variables for all pancreaticoduodenectomies from 2014-2017 were examined using a national clinical registry. The cohort was separated into risk factor identification and internal validation subgroups.

resultsAmong 15 033 pancreaticoduodenectomies, the CR-POPF rate was 16.7%. CR-POPF was more likely in patients that were male (odds ratio [OR], 1.51), obese (body mass index [BMI] > 30, OR, 1.97), had minimal preoperative weight loss (OR, 1.25), had a nondilated pancreatic duct (OR, 1.81), did not have diabetes, (OR, 1.80), did not receive neoadjuvant therapy (OR, 1.78), had no evidence of biliary obstruction (OR, 1.18), or had nonadenocarcinoma pathology (OR, 1.96; all P < 0.01). Patients with three or fewer risk factors had a CR-POPF rate of 7.1%, while those with six or more risk factors had a CR-POPF rate of 26.3% (P < 0.001).

conclusionPreoperative CR-POPF risk evaluation could be a useful tool in patient counseling and surgical planning, and risk may allow for more well-informed decisions regarding perioperative management, including enhanced recovery protocols and use of somatostatin analogs.

Indexed as

AdolescentAdultAgedAged, 80 and overCohort StudiesFemaleHumansMaleMiddle AgedPancreatic FistulaPancreaticoduodenectomyPreoperative CareRegistriesReproducibility of ResultsRetrospective StudiesRisk Factorspancreatic fistulapancreaticoduodenectomypancreatic surgeryWhipple procedure

Identifiers

PMID30951614
PMCPMC6894415

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.