ArticleIEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society2019
A Carbon Slurry Separated Interface Nerve Electrode for Electrical Block of Nerve Conduction.
Article in IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Single-Electrode, Bidirectional Control of Heart Rate via Vagus Nerve Modulation in Rat Model.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2026Article
- Closed-loop bioelectronic block of stellate ganglia reduces neurotransmitter release and improves recovery following programmed ventricular pacing.Frontiers in bioengineering and biotechnology · 2026Article
- Temporal properties of direct current sensory block of the rat sciatic nerve using the C-fiber reflex.Journal of neural engineering · 2025Article
- Effect of Ultrasonic Treatment of Dispersed Carbon Nanocomposite Media on the Formation, Electrical Conductivity, and Degradation of a Hydrogel for Metallic Stimulation Electrodes.Gels (Basel, Switzerland) · 2025Article
- Electrophysiological Methods to Assess Peripheral Pain Block in an Anesthetized Rat.Journal of visualized experiments : JoVE · 2025Article
- Closed-loop electrical block of vagus nerve scales from rodent to porcine cardiac models.Journal of neural engineering · 2025Article
- Ramped kilohertz-frequency signals produce nerve conduction block without onset response.Journal of neural engineering · 2025Article
- Bioelectronic block of stellate ganglia mitigates pacing-induced heterogeneous release of catecholamine and neuropeptide Y in the infarcted pig heart.The Journal of physiology · 2025Article
- Temporal properties of transcutaneous direct current motor conduction block.Journal of neural engineering · 2025Article
- Peripheral direct current reduces naturally evoked nociceptive activity at the spinal cord in rodent models of pain.Journal of neural engineering · 2024Article
- Model Analysis of Post-Stimulation Block of a Myelinated Axon by Direct Current.IEEE transactions on bio-medical engineering · 2023Article
- Effects on heart rate from direct current block of the stimulated rat vagus nerve.Journal of neural engineering · 2023Article
- Effects of waveform shape and electrode material on KiloHertz frequency alternating current block of mammalian peripheral nerve.Bioelectronic medicine · 2022Article
- A Hydrogel-Based Microfluidic Nerve Cuff for Neuromodulation of Peripheral Nerves.Micromachines · 2021Article
- Model Analysis of Post-Stimulation Effect on Axonal Conduction and Block.IEEE transactions on bio-medical engineering · 2021Article
- Fuzzy Logic Control of Heartrate by Electrical Block of Vagus Nerve.International IEEE/EMBS Conference on Neural Engineering : [proceedings]. International IEEE EMBS Conference on Neural Engineering · 2021Article
- Combining direct current and kilohertz frequency alternating current to mitigate onset activity during electrical nerve block.Journal of neural engineering · 2021Article
- Non-monotonic kilohertz frequency neural block thresholds arise from amplitude- and frequency-dependent charge imbalance.Scientific reports · 2021Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Direct current (DC) nerve block has been shown to provide a complete block of nerve conduction without unwanted neural firing. Previous work shows that high capacitance electrodes can be used to safely deliver a DC block. Another way of delivering DC safely is through a separated interface nerve electrode (SINE), such that any reactive species that are generated by the passage of DC are contained in a vessel away from the nerve. This design has been enhanced by using a high capacitance carbon "slurry" as the electrode in the external vessel to extend the capacity of the electrode (CSINE). With this new design, it was possible to provide 50 min of continuous nerve block without recharge while still maintaining complete recovery of neural signals. Up to 46 C of charge delivery was applied for a total of 4 h of nerve block with complete recovery. Because of the extended delivery time, it was possible to explore several properties of DC block that would not be revealed without the capability of a long-duration continuous block. It was possible to achieve complete block at lower values of DC if the block was applied for a longer period of time. Depending on the amount of charge applied during the block, the recovery was delayed for a period of time before complete force recovery was restored. These new properties provide novel techniques for device development to optimize charge delivery time and device powering concerns.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.