Evidence map›Paper›PMID 30951400›Full record

ArticlemAbs2019

Diabody-Ig: a novel platform for the generation of multivalent and multispecific antibody molecules.

Oliver Seifert, Alexander Rau, Nadine Beha, Fabian Richter, Roland E Kontermann

Open access · goldAbstract read
In one paragraph

Article in mAbs, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. The potential of monoclonal antibodies for colorectal cancer therapy.Medical oncology (Northwood, London, England) · 2023
    Review
  5. Review
  6. HER3 in cancer: from the bench to the bedside.Journal of experimental & clinical cancer research : CR · 2022
    Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Oliver Seiferta Institute of Cell Biology and Immunology , University of Stuttgart , Stuttgart , Germany.ORCID 0000-0003-1876-4212
Alexander Raua Institute of Cell Biology and Immunology , University of Stuttgart , Stuttgart , Germany.ORCID 0000-0001-6810-2714
Nadine Behaa Institute of Cell Biology and Immunology , University of Stuttgart , Stuttgart , Germany.ORCID 0000-0002-9385-9740
Fabian Richtera Institute of Cell Biology and Immunology , University of Stuttgart , Stuttgart , Germany.ORCID 0000-0002-9655-4723
Roland E Kontermanna Institute of Cell Biology and Immunology , University of Stuttgart , Stuttgart , Germany.ORCID 0000-0001-7139-1350
University of Stuttgart · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multivalent mono- or bispecific antibodies are of increasing interest for therapeutic applications, such as efficient receptor clustering and activation, or dual targeting approaches. Here, we present a novel platform for the generation of Ig-like molecules, designated diabody-Ig (Db-Ig). The antigen-binding site of Db-Ig is composed of a diabody in the V

Indexed as

DimerizationAntibodies, BispecificApoptosisErbB ReceptorsHumansImmunoglobulin GImmunoglobulin MReceptor, ErbB-3Antibodies, BispecificEGFR protein, humanERBB3 protein, humanErbB ReceptorsImmunoglobulin GImmunoglobulin MReceptor, ErbB-3Antibodybispecificdiabodydual targetingEGFRHER3heterodimerizationhomodimerizationplatformtetravalent

Identifiers

PMID30951400
PMCPMC6601561
OpenAlexW2931445906

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.