ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2019
Integrative analysis of the forkhead box A2 (FOXA2) cistrome for the human endometrium.
Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 28 citations in OpenAlex.
- Generation and Characterization of a Rdh1-iCre Line to Study Uterine Glandular Biology.Genesis (New York, N.Y. : 2000) · 2026Article
- Molecular signature of human endometrial stem/progenitor cells at the single-cell level.Stem cell reports · 2026Article
- Progesterone receptor in uterine glands is required for pregnancy establishment in mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- FOXA2 loss results in an increase of endometriosis development and LIF reveals a therapeutic effect for endometriosis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- Foxa2-dependent uterine glandular cell differentiation is essential for successful implantation.Nature communications · 2025Article
- The endometrial transcriptome of infertile women with and without implantation failure.Acta obstetricia et gynecologica Scandinavica · 2024Article
- An Integrative ATAC-Seq and RNA-Seq Analysis of the Endometrial Tissues of Meishan and Duroc Pigs.International journal of molecular sciences · 2023Article
- Deciphering a shared transcriptomic regulation and the relative contribution of each regulator type through endometrial gene expression signatures.Reproductive biology and endocrinology : RB&E · 2023Article
- Basolateral secretions of human endometrial epithelial organoids impact stromal cell decidualization.Molecular human reproduction · 2023Article
- Role of EZH2 in Uterine Gland Development.International journal of molecular sciences · 2022Article
- Single-cell transcriptomic analysis highlights origin and pathological process of human endometrioid endometrial carcinoma.Nature communications · 2022Article
- Mouse Cre drivers: tools for studying disorders of the human female neuroendocrine-reproductive axis†.Biology of reproduction · 2022Review
- Roles of WNT6 in Sheep Endometrial Epithelial Cell Cycle Progression and Uterine Glands Organogenesis.Veterinary sciences · 2021Article
- Generation and analysis of Prss28 and Prss29 deficient mice using CRISPR-Cas9 genome-editing.Molecular reproduction and development · 2021Article
- In vitro models of the human endometrium: evolution and application for women's health.Biology of reproduction · 2021Review
- Endometrial epithelial ARID1A is critical for uterine gland function in early pregnancy establishment.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021Article
- Single-cell transcriptomic atlas of the human endometrium during the menstrual cycle.Nature medicine · 2020Article
- Sexually dimorphic effects of forkhead box a2 (FOXA2) and uterine glands on decidualization and fetoplacental development.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Self-renewing endometrial epithelial organoids of the human uterus.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Uterine Glands: Developmental Biology and Functional Roles in Pregnancy.Endocrine reviews · 2019Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
The pioneer forkhead box (FOX)A2 transcription factor is specifically expressed in the glands of the uterus, which are central to endometrial function and fertility. In mice, FOXA2 is a critical regulator of uterine gland development in the neonate and gland function in the adult. An integrative approach was used here to define the FOXA2 cistrome in the human endometrium. Genome-wide mapping of FOXA2 binding intervals by chromatin immunoprecipitation sequencing was performed using proliferative (P)- and midsecretory (MS)-phase endometrium and integrated with the transcriptome determined by RNA sequencing. Distinctive FOXA2 binding intervals, enriched for different transcription factor binding site motifs, were detected in the P and MS endometrium. Pathway analysis revealed different biologic processes regulated by genes with FOXA2 binding intervals in the P and MS endometrium. Thus, FOXA2 is postulated to regulate gene expression in concert with other transcription factors and impact uterine gland development and function in a cycle phase-dependent manner. Analyses also identified potential FOXA2-regulated genes that influence uterine receptivity, blastocyst implantation, and stromal cell decidualization, which are key events in pregnancy establishment.-Kelleher, A. M., Behura, S. K., Burns, G. W., Young, S. L., DeMayo, F. J., Spencer, T. E. Integrative analysis of the forkhead box A2 (FOXA2) cistrome for the human endometrium.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.