ArticlePlant biotechnology journal2019
RrMYB5- and RrMYB10-regulated flavonoid biosynthesis plays a pivotal role in feedback loop responding to wounding and oxidation in Rosa rugosa.
Article in Plant biotechnology journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.
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64 citing papers in PubMed, 126 citations in OpenAlex.
- The RcDREB1E-RcMYB28 module improves drought tolerance in Rosa chinensis via RcLAR/RcCORA1-mediated proanthocyanidin biosynthesis and stress responses.The Plant journal : for cell and molecular biology · 2026Article
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- Unveiling Dynamic Defense Pathways: Transcriptome Analysis of Phenylpropanoids and (Iso)flavonoids in Cowpea Leaves Post-CABMV Inoculation.Biochemical genetics · 2026Article
- Plant Flavonoids: Biosynthesis, Regulation, and Roles in Biotic and Abiotic Stresses.Plant, cell & environment · 2026Review
- LlR3MYB-mediated flavonoid biosynthesis confers cold stress tolerance inHorticulture research · 2026Article
- Transcriptome analysis reveals the mechanism and key role of CdPER47 in bermudagrass (Cynodon dactylon) adaptation to submergence and post-submergence stresses.BMC plant biology · 2026Article
- Genome-Wide Identification of the R2R3-MYB Gene Family Members in Masson Pine and the Regulation of Secondary Cell Wall Formation and Lignin Biosynthesis byPlants (Basel, Switzerland) · 2026Article
- Improved Longan Genome Assembly Reveals Insights Into Flowering Mechanisms.Plant biotechnology journal · 2026Article
- An R2R3-MYB transcription factor TgMYB44 positively regulates petal senescence by enhancing ABA biosynthesis in tulip.Plant cell reports · 2026Article
- Transcriptomic and metabolomic analyses reveal the role of flavonoids in ectomycorrhizal symbiosis.Mycorrhiza · 2026Article
- JA Regulates Caffeine Biosynthesis in Tea Leaf for Resistance Against Fungal Infection and Antagonises With GA to Balance the Defence-Growth Trade-Off via CsDELLA-JAZ-MYC2-MYB184-TCS1 Module.Plant biotechnology journal · 2025Article
- Transcriptome analysis reveals the mechanism of anthocyanin accumulation induced by leaf breakage in foxtail millet.BMC plant biology · 2025Article
- Integrated transcriptome and metabolome analyses provide molecular insights into the transition of flower color in the rose cultivar 'Juicy Terrazza'.BMC plant biology · 2025Article
- Advancing ornamental plant breeding through genomic technologies: opportunities, challenges, and future directions.Functional & integrative genomics · 2025Review
- Characterization of a KANADI-like transcription factor that suppresses pear anthocyanin biosynthesis.Horticulture research · 2025Article
- Divergent MYB paralogs determine spatial distribution of linalool mediated by JA and DNA demethylation participating in aroma formation and cold tolerance of tea plants.Plant biotechnology journal · 2025Article
- Phenotypic and genomic signatures across wild Rosa species open new horizons for modern rose breeding.Nature plants · 2025Article
- Flavonoids as key players in cold tolerance: molecular insights and applications in horticultural crops.Horticulture research · 2025Article
- Article
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15 authors at 4 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Flavonoids play critical roles in plant responses to various stresses. Few studies have been reported on what the mechanism of activating flavonoid biosynthesis in plant responses to wounding and oxidation is. In this study, flavonoid metabolites and many MYB transcript factors from Rosa rugosa were verified to be induced by wounding and oxidation. RrMYB5 and RrMYB10, which belong to PA1- and TT2-type MYB TFs, respectively, showed extremely high induction. Overexpression of RrMYB5 and RrMYB10 resulted in an increased accumulation of proanthocyanidins in R. rugosa and tobacco by promoting the expression of flavonoid structural genes. Transcriptomic analysis of the transgenic plants showed that most genes, involved in wounding and oxidation response and ABA signalling modulation, were up-regulated by the overexpression of RrMYB10, which was very much similar to that observed in RrANR and RrDFR overexpression transgenics. RrMYB5 and RrMYB10 physically interacted and mutually activated each other's expressions. They solely or synergistically activated the different sets of flavonoid pathway genes in a bHLH TF EGL3-independent manner. Eventually, the accumulation of proanthocyanidins enhanced plant tolerance to wounding and oxidative stresses. Therefore, RrMYB5 and RrMYB10 regulated flavonoid synthesis in feedback loop responding to wounding and oxidation in R. rugosa. Our study provides new insights into the regulatory mechanisms of flavonoid biosynthesis by MYB TFs and their essential physiological functions in plant responses to wounding and oxidative stresses.
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