Evidence map›Paper›PMID 30951015›Full record

ReviewTransplantation2019

Is There a Role for Natural Antibodies in Rejection Following Transplantation?

Emmanuel Zorn, Sarah B See

Open access · greenAbstract readReview
In one paragraph

Review in Transplantation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 21 citations in OpenAlex.

  1. Best practices of heart transplantation in mice.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2025
    Review
  2. Marginal zone B cells are required for optimal humoral responses to allograft.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2025
    Article
  3. Review
  4. Review
  5. Autoantibodies against DNA topoisomerase I promote renal allograft rejection by increasing alloreactive T cell responses.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2023
    Article
  6. Article
  7. Article
  8. Article
  9. B cell clonal expansion within immune infiltrates in human cardiac allograft vasculopathy.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2020
    Article
  10. Novel insights into non-HLA alloimmunity in kidney transplantation.Transplant international : official journal of the European Society for Organ Transplantation · 2020
    Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Emmanuel ZornColumbia Center for Translational Immunology, Columbia University Medical Center, New York, NY.
Sarah B SeeColumbia Center for Translational Immunology, Columbia University Medical Center, New York, NY.
Columbia University Irving Medical Center · US

Funding

Innate B cell immunity and antibody-mediated rejection of human kidney allograftsR01AI123342 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Emmanuel Zorn · 2016 to 2026
$3.3M
Contribution of B cells to human cardiac allograft vasculopathyR01AI116814 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ZORN, EMMANUEL · 2015 to 2019
$1.8M
NIAID NIH HHS R01 AI116814NIAID NIH HHS R01 AI123342
6 · The paper itself

Abstract

Antibody-mediated rejection continues to hinder long-term survival of solid organ allografts. Natural antibodies (Nabs) with polyreactive and autoreactive properties have recently emerged as potential contributors to antibody-mediated graft rejection. This review discusses Nabs, their functions in health and disease, their significance in rejection following kidney, heart, and lung transplantation, and their implication in serum reactivity to key antigens associated with rejection. Finally, potential effector mechanisms of Nabs in the context of transplantation are explored.

Indexed as

AutoimmunityOrgan TransplantationAntibodiesGraft RejectionGraft SurvivalHLA AntigensHumansAntibodiesHLA Antigens

Identifiers

PMID30951015
PMCPMC6660357
OpenAlexW2938200930

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.