Evidence map›Paper›PMID 30950790›Full record

ArticleeLife2019

A bacterial riboswitch class for the thiamin precursor HMP-PP employs a terminator-embedded aptamer.

Ruben M Atilho, Gayan Mirihana Arachchilage, Etienne B Greenlee, Kirsten M Knecht, Ronald R Breaker

Abstract read
In one paragraph

Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. NaNature chemical biology · 2022
    Article
  6. Key players in regulatory RNA realm of bacteria.Biochemistry and biophysics reports · 2022
    Review
  7. Variants of the guanine riboswitch class exhibit altered ligand specificities for xanthine, guanine, or 2'-deoxyguanosine.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  8. Article
  9. Riboswitch RSApplied and environmental microbiology · 2022
    Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ruben M Atilho *Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, United States.
Gayan Mirihana Arachchilage *Howard Hughes Medical Institute, Yale University, New Haven, United States.
Etienne B GreenleeDepartment of Molecular, Cellular and Developmental Biology, Yale University, New Haven, United States.
Kirsten M KnechtDepartment of Molecular Biophysics and Biochemistry, Yale University, New Haven, United States.
Ronald R BreakerDepartment of Molecular Biophysics and Biochemistry, Yale University, New Haven, United States.ORCID 0000-0002-2165-536X

Funding

X-RAY ANALYSIS OF PROTEIN STRUCTURE AND FUNCTIONP01GM022778 · NIGMS · YALE UNIVERSITY · PI BREAKER, RONALD R · 1985 to 2019
$26.1M
Translational CoreP01DK057751 · NIDDK · YALE UNIVERSITY · PI NATHANSON, MICHAEL H · 2001 to 2020
$25.6M
INSTITUTIONAL NATIONAL RESEARCH SERVICE AWARDT32GM007324 · NIGMS · YALE UNIVERSITY · PI BENNETT, ANTON M · 1987 to 2022
$6.2M
YALE BIOMEDICAL SUPERCOMPUTER: NEUROSCIENCES10RR019895 · NCRR · YALE UNIVERSITY · PI WILLIAMS, KENNETH ROBERT · 2004 to 2004
$1.6M
Howard Hughes Medical Institute Investigator FundingNational Science Foundation Graduate Student FellowshipNCRR NIH HHS S10 RR019895NIDDK NIH HHS P01 DK057751NIGMS NIH HHS P01 GM022778NIGMS NIH HHS T32 GM007324NIH HHS P01 GM022778
6 · The paper itself

Abstract

We recently implemented a bioinformatics pipeline that can uncover novel, but rare, riboswitch candidates as well as other noncoding RNA structures in bacteria. A prominent candidate revealed by our initial search efforts was called the '

Indexed as

Gene Expression Regulation, BacterialRiboswitchAptamers, NucleotideBacillus subtilisDiphosphatesNucleic Acid ConformationPyrimidinesRNA, BacterialSulfuric Acid EstersThiamine4-amino-5-hydroxymethyl-2-methylpyrimidine pyrophosphateAptamers, NucleotideDiphosphateshydroxyethyl thiosulfatePyrimidinesRiboswitchRNA, BacterialSulfuric Acid EstersThiaminebiochemistrychemical biologyE. coligene regulationpseudoknotRNA transcriptionthiamin pyrophosphate

Identifiers

PMID30950790
PMCPMC6478431

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.