Evidence map›Paper›PMID 30950584›Full record

ArticleObesity (Silver Spring, Md.)2019

Parental Education and Genetics of BMI from Infancy to Old Age: A Pooled Analysis of 29 Twin Cohorts.

Karri Silventoinen, Aline Jelenkovic, Antti Latvala, Yoshie Yokoyama, Reijo Sund, Masumi Sugawara, Mami Tanaka, Satoko Matsumoto, Sari Aaltonen, Maarit Piirtola and 63 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Obesity (Silver Spring, Md.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. The CODATwins Project: The Current Status and Recent Findings of COllaborative Project of Development of Anthropometrical Measures in Twins.Twin research and human genetics : the official journal of the International Society for Twin Studies · 2019
    Trial
  5. Article
  6. Article
  7. Article
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  9. Behavioural susceptibility theory: the role of appetite in genetic susceptibility to obesity in early life.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023
    Review
  10. The social origins of obesity within and across generations.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2023
    Review
  11. Article
  12. Article
  13. Article
  14. [Twin research in Germany].Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

73 authors.

Karri SilventoinenDepartment of Social Research, University of Helsinki, Helsinki, Finland.ORCID 0000-0003-1759-3079
Aline JelenkovicDepartment of Social Research, University of Helsinki, Helsinki, Finland.
Antti LatvalaDepartment of Public Health, University of Helsinki, Helsinki, Finland.
Yoshie YokoyamaDepartment of Public Health Nursing, Osaka City University, Osaka, Japan.
Reijo SundDepartment of Social Research, University of Helsinki, Helsinki, Finland.
Masumi SugawaraDepartment of Psychology, Ochanomizu University, Tokyo, Japan.
Mami TanakaCenter for Forensic Mental Health, Chiba University, Chiba, Japan.
Satoko MatsumotoInstitute for Education and Human Development, Ochanomizu University, Tokyo.
Sari AaltonenDepartment of Social Research, University of Helsinki, Helsinki, Finland.
Maarit PiirtolaDepartment of Social Research, University of Helsinki, Helsinki, Finland.
Duarte L FreitasDepartment of Physical Education and Sport, University of Madeira, Funchal, Portugal.
José A MaiaFaculty of Sport, University of Porto, Porto, Portugal.
Sevgi Y ÖncelDepartment of Statistics, Faculty of Arts and Sciences, Kırıkkale University, Kırıkkale, Turkey.
Fazil AlievDepartments of Psychology and African American Studies, Virginia Commonwealth University, Richmond, Virginia, USA.
Fuling JiDepartment of Noncommunicable Diseases Prevention, Qingdao Centers for Disease Control and Prevention, Qingdao, China.ORCID 0000-0002-3261-0204
Feng NingDepartment of Noncommunicable Diseases Prevention, Qingdao Centers for Disease Control and Prevention, Qingdao, China.
Zengchang PangDepartment of Noncommunicable Diseases Prevention, Qingdao Centers for Disease Control and Prevention, Qingdao, China.
Esther RebatoDepartment of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country, Leioa, Spain.
Kimberly J SaudinoDepartment of Psychological and Brain Sciences, Boston University, Boston, Massachusetts, USA.
Tessa L CutlerThe Australian Twin Registry, Centre for Epidemiology and Biostatistics, University of Melbourne, Melbourne, Victoria, Australia.
John L HopperThe Australian Twin Registry, Centre for Epidemiology and Biostatistics, University of Melbourne, Melbourne, Victoria, Australia.
Vilhelmina UllemarDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Catarina AlmqvistDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Patrik K E MagnussonDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Wendy CozenDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Amie E HwangDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Thomas M MackDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Gonneke WillemsenNetherlands Twin Register, Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.
Meike BartelsNetherlands Twin Register, Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.
Catharina E M van BeijsterveldtNetherlands Twin Register, Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.
Tracy L NelsonDepartment of Health and Exercise Sciences, Colorado School of Public Health, Colorado State University, Fort Collins, Colorado, USA.
Keith E WhitfieldDepartment of Psychology and Neuroscience, Duke University, Durham, North Carolina, USA.
Joohon SungDepartment of Epidemiology, School of Public Health, Seoul National University, Seoul, South Korea.
Jina KimDepartment of Epidemiology, School of Public Health, Seoul National University, Seoul, South Korea.
Jooyeon LeeDepartment of Epidemiology, School of Public Health, Seoul National University, Seoul, South Korea.
Sooji LeeDepartment of Epidemiology, School of Public Health, Seoul National University, Seoul, South Korea.
Clare H LlewellynHealth Behaviour Research Centre, Department of Epidemiology and Public Health, Institute of Epidemiology and Health Care, University College London, London, UK.
Abigail FisherHealth Behaviour Research Centre, Department of Epidemiology and Public Health, Institute of Epidemiology and Health Care, University College London, London, UK.
Emanuela MeddaCenter for Behavioral Sciences and Mental Health, Higher Institute of Health, Rome, Italy.
Lorenza NisticòCenter for Behavioral Sciences and Mental Health, Higher Institute of Health, Rome, Italy.
Virgilia ToccaceliCenter for Behavioral Sciences and Mental Health, Higher Institute of Health, Rome, Italy.
Laura A BakerDepartment of Psychology, University of Southern California, Los Angeles, California, USA.
Catherine TuvbladDepartment of Psychology, University of Southern California, Los Angeles, California, USA.
Robin P CorleyInstitute for Behavioral Genetics, University of Colorado, Boulder, Colorado, USA.
Brooke M HuibregtseInstitute of Behavioral Science, University of Colorado, Boulder, Colorado, USA.ORCID 0000-0003-0977-7249
Catherine A DeromCenter of Human Genetics, University Hospitals Leuven, Leuven, Belgium.
Robert F VlietinckCenter of Human Genetics, University Hospitals Leuven, Leuven, Belgium.
Ruth J F LoosThe Charles Bronfman Institute for Personalized Medicine, The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Ariel Knafo-NoamPsychology Department, The Hebrew University of Jerusalem, Jerusalem, Israel.
David MankutaObstetrics and Gynecology Department, Hadassah Hospital, Hebrew University Medical School, Jerusalem, Israel.
Lior AbramsonPsychology Department, The Hebrew University of Jerusalem, Jerusalem, Israel.
S Alexandra BurtDepartment of Psychology, Michigan State University, East Lansing, Michigan, USA.
Kelly L KlumpDepartment of Psychology, Michigan State University, East Lansing, Michigan, USA.
Judy L SilbergDepartment of Human and Molecular Genetics, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia, USA.
Hermine H MaesDepartment of Human and Molecular Genetics, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia, USA.
Robert F KruegerDepartment of Psychology, University of Minnesota, Minneapolis, Minnesota, USA.
Matt McGueDepartment of Psychology, University of Minnesota, Minneapolis, Minnesota, USA.
Shandell PahlenDepartment of Psychology, University of Minnesota, Minneapolis, Minnesota, USA.
Margaret GatzDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
David A ButlerHealth and Medicine Division, The National Academies of Sciences, Engineering, and Medicine, Washington, DC, USA.
Jennifer R HarrisNorwegian Institute of Public Health, Oslo, Norway.
Thomas S NilsenNorwegian Institute of Public Health, Oslo, Norway.
K Paige HardenDepartment of Psychology, University of Texas at Austin, Austin, Texas, USA.
Elliot M Tucker-DrobDepartment of Psychology, University of Texas at Austin, Austin, Texas, USA.
Carol E FranzDepartment of Psychiatry, University of California San Diego, San Diego, California, USA.
William S KremenDepartment of Psychiatry, University of California San Diego, San Diego, California, USA.
Michael J LyonsDepartment of Psychology, Boston University, Boston, Massachusetts, USA.
Paul LichtensteinDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Hoe-Uk JeongDepartment of Education, Mokpo National University, Jeonnam, South Korea.
Yoon-Mi HurDepartment of Education, Mokpo National University, Jeonnam, South Korea.
Dorret I BoomsmaNetherlands Twin Register, Department of Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.
Thorkild I A SørensenSection of Metabolic Genetics, Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Jaakko KaprioDepartment of Public Health, University of Helsinki, Helsinki, Finland.

Funding

The VETSA Longitudinal Twin Study of Cognition and Aging (VETSA 4)R01AG050595 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ELMAN, JEREMY A, FRANZ, CAROL ELAINE · 2015 to 2024
$28.0M
Twin StudyP60DA011015 · NIDA · UNIVERSITY OF COLORADO DENVER · PI HEWITT, JOHN K. · 1997 to 2013
$22.5M
The VETSA Longitudinal MRI Twin Study of AgingR01AG022381 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KREMEN, WILLIAM S. · 2003 to 2019
$22.3M
Research Supplement to Promote Diversity in Health Related ResearchUL1TR002649 · NCATS · VIRGINIA COMMONWEALTH UNIVERSITY · PI MOELLER, FREDERICK GERARD · 2018 to 2022
$19.1M
The VETSA Longitudinal Twin Study of Cognition and AgingR01AG018384 · NIA · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI LYONS, MICHAEL J. · 2002 to 2012
$9.8M
The VETSA longitudinal twin study of cognition and agingR01AG018386 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KREMEN, WILLIAM S. · 2002 to 2012
$9.7M
The VETSA Longitudinal MRI Twin Study of Aging (VETSA MRI 4)R01AG076838 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ANDERS M DALE, Jeremy A Elman · 2022 to 2026
$8.7M
RISK FACTORS FOR ANTISOCIAL BEHAVIORR01MH058354 · NIMH · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BAKER, LAURA A · 2000 to 2013
$8.5M
Research Training-Genetics of Substance AbuseT32DA017637 · NIDA · UNIVERSITY OF COLORADO AT BOULDER · PI STITZEL, JERRY A · 2004 to 2023
$5.3M
Scientific & Technical CoreP2CHD042849 · NICHD · UNIVERSITY OF TEXAS AT AUSTIN · PI Catherine A Calder · 2017 to 2026
$5.2M
Clarifying risk and protective factors for dementia with the Interplay of Genes and Environment in Multiple Studies (IGEMS) consortiumR01AG060470 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI GATZ, MARGARET, PEDERSEN, NANCY L · 2018 to 2022
$3.6M
The Effects of Estradiol on Genetic Risk for Disordered Eating During PubertyR01MH092377 · NIMH · MICHIGAN STATE UNIVERSITY · PI KLUMP, KELLY L · 2010 to 2014
$3.4M
Boston University Twin Project R01HD068435Boston University Twin Project R01MH062375Cancer Research UK C1418/A7974Michigan State University (MSU) R01MH081813Michigan State University (MSU) R01MH0820-54Michigan State University (MSU) R01MH092377-02Michigan State University (MSU) R03MH63851-01Michigan State University (MSU) R21MH070542-01National Institute of Mental Health (NIMH) R01HD066040National Institute on Aging (NIA 1R01AG13662-01A2NCATS NIH HHS UL1 TR002649NIAAA NIH HHS K05 AA000145NIAAA NIH HHS R01 AA009203NIAAA NIH HHS R01 AA012502NIAAA NIH HHS R21 AA023322NIAAA NIH HHS R37 AA012502NIA NIH HHS 1R01AG13662-01A2NIA NIH HHS R01 AG013662NIA NIH HHS R01 AG018384NIA NIH HHS R01 AG018386NIA NIH HHS R01 AG022381NIA NIH HHS R01 AG022982NIA NIH HHS R01 AG050595NIA NIH HHS R01 AG060470NIA NIH HHS R01 AG076838NIA NIH HHS R21 AG039572NIA NIH HHS T32 AG052371NICHD NIH HHS P2C HD042849NICHD NIH HHS R01 HD010333NICHD NIH HHS R01 HD066040NICHD NIH HHS R01 HD068435NICHD NIH HHS R21 HD081437NIDA NIH HHS P60 DA011015NIDA NIH HHS T32 DA017637NIEHS NIH HHS R01 ES015150NIH HHS R21AG039572NIMH NIH HHS R01 MH058354NIMH NIH HHS R01 MH062375NIMH NIH HHS R01 MH081813NIMH NIH HHS R01 MH092377NIMH NIH HHS R01MH58354NIMH NIH HHS R03 MH063851NIMH NIH HHS R21 MH070542Vietnam Era Twin Study of Aging R01AG018384Vietnam Era Twin Study of Aging R01AG018386Vietnam Era Twin Study of Aging R01AG022381Vietnam Era Twin Study of Aging R01AG022982
6 · The paper itself

Abstract

objectiveThe objective of this study was to analyze how parental education modifies the genetic and environmental variances of BMI from infancy to old age in three geographic-cultural regions.

methodsA pooled sample of 29 cohorts including 143,499 twin individuals with information on parental education and BMI from age 1 to 79 years (299,201 BMI measures) was analyzed by genetic twin modeling.

resultsUntil 4 years of age, parental education was not consistently associated with BMI. Thereafter, higher parental education level was associated with lower BMI in males and females. Total and additive genetic variances of BMI were smaller in the offspring of highly educated parents than in those whose parents had low education levels. Especially in North American and Australian children, environmental factors shared by co-twins also contributed to the higher BMI variation in the low education level category. In Europe and East Asia, the associations of parental education with mean BMI and BMI variance were weaker than in North America and Australia.

conclusionsLower parental education level is associated with higher mean BMI and larger genetic variance of BMI after early childhood, especially in the obesogenic macro-environment. The interplay among genetic predisposition, childhood social environment, and macro-social context is important for socioeconomic differences in BMI.

Indexed as

Body Mass IndexGene-Environment InteractionAdolescentAdultAgedChildChild, PreschoolCohort StudiesFemaleHumansInfantMaleMiddle AgedParentsTwinsYoung Adult

Identifiers

PMID30950584
PMCPMC6478550

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.