Evidence map›Paper›PMID 30950251›Full record

ArticleJournal of Korean medical science2019

Infantile Anaphylaxis in Korea: a Multicenter Retrospective Case Study.

You Hoon Jeon, Sooyoung Lee, Kangmo Ahn, So Yeon Lee, Kyung Won Kim, Hyun Hee Kim, Jeong Hee Kim, Hye Yung Yum, Woo Kyung Kim, Yong Mean Park and 9 more

Open access · goldAbstract read
In one paragraph

Article in Journal of Korean medical science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 47 citations in OpenAlex.

  1. Food-induced anaphylaxis in children less than 2 years of age.Postepy dermatologii i alergologii · 2025
    Article
  2. Article
  3. Development and Evaluation of Modified Criteria for Infant and Toddler Anaphylaxis.The journal of allergy and clinical immunology. In practice · 2024
    Article
  4. Article
  5. Article
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  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Recent update on the management of anaphylaxis.Clinical and experimental emergency medicine · 2021
    Article
  13. Article
  14. Infant Anaphylaxis: A Diagnostic Challenge.Current allergy and asthma reports · 2021
    Review
  15. IgE-Mediated Fish Allergy in Children.Medicina (Kaunas, Lithuania) · 2021
    Review
  16. World allergy organization anaphylaxis guidance 2020.The World Allergy Organization journal · 2020
    Article
  17. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors at 11 institutions in 1 country.

You Hoon JeonDepartment of Pediatrics, Hallym University Dongtan Sacred Heart Hospital, Hallym University College of Medicine, Hwaseong, Korea.ORCID https://orcid.org/0000-0002-8164-7580
Sooyoung LeeDepartment of Pediatrics, Ajou University Hospital, Ajou University School of Medicine, Suwon, Korea. jsjs87@ajou.ac.kr.ORCID https://orcid.org/0000-0003-1734-4101
Kangmo AhnDepartment of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0001-7751-9829
So Yeon LeeDepartment of Pediatrics, Childhood Asthma Atopy Center, Environmental Health Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0002-2499-0702
Kyung Won KimDepartment of Pediatrics, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0003-1178-5301
Hyun Hee KimDepartment of Pediatrics, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.ORCID https://orcid.org/0000-0002-7196-2894
Jeong Hee KimDepartment of Pediatrics, Inha University Hospital, Inha University College of Medicine, Incheon, Korea.ORCID https://orcid.org/0000-0002-7054-8552
Hye Yung YumDepartment of Pediatrics, Seoul Medical Center, Seoul, Korea.ORCID https://orcid.org/0000-0002-3997-4094
Woo Kyung KimDepartment of Pediatrics, Inje University Ilsan Paik Hospital, Inje University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0001-8730-010X
Yong Mean ParkDepartment of Pediatrics, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0002-2586-584X
Tae Won SongDepartment of Pediatrics, Inje University Ilsan Paik Hospital, Inje University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0001-6443-5749
Jihyun KimDepartment of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0001-8493-2881
Yong Ju LeeDepartment of Pediatrics, Hallym University Dongtan Sacred Heart Hospital, Hallym University College of Medicine, Hwaseong, Korea.ORCID https://orcid.org/0000-0002-0796-2558
Gwang Cheon JangDepartment of Pediatrics, National Health Insurance Corporation Ilsan Hospital, Seoul, Korea.ORCID https://orcid.org/0000-0002-2423-9951
Kyunguk JeongDepartment of Pediatrics, Ajou University Hospital, Ajou University School of Medicine, Suwon, Korea.ORCID https://orcid.org/0000-0002-1261-4507
Yoon Hee KimDepartment of Pediatrics, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0002-2149-8501
Taek Ki MinDepartment of Pediatrics, Soonchunhyang University Seoul Hospital, Seoul, Korea.ORCID https://orcid.org/0000-0002-5078-5622
Bok Yang PyunDepartment of Pediatrics, Soonchunhyang University Seoul Hospital, Seoul, Korea. bypyun@schmc.ac.kr.ORCID https://orcid.org/0000-0002-6375-9394
Food Allergy and Atopic Dermatitis (FAAD) Study Group in the Korean Academy of Pediatric Allergy and Respiratory Disease
Samsung Medical Center · KRHallym University Dongtan Sacred Heart Hospital · KRInje University · KRSoonchunhyang University Hospital Seoul · KRUlsan College · KRYonsei University · KRAjou University Hospital · KRKonkuk University Medical Center · KRNational Health Insurance Service · KRSeoul Medical Center · KRThe Catholic University of Korea Uijeongbu St. Mary's Hospital · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAnaphylaxis is increasing in young children. The aim of the present study was to analyze the clinical characteristics of anaphylaxis in Korean infants, with a focus on food triggers.

methodsThe study analyzed the medical records of infants aged 0 to 2 years old who had been diagnosed with anaphylaxis in 23 secondary or tertiary hospitals in Korea.

resultsWe identified 363 cases of infantile anaphylaxis (66.9% male). Cutaneous symptoms were most prevalent (98.6%), followed by respiratory (83.2%), gastrointestinal (29.8%), and neurologic (11.6%) symptoms. Cardiovascular symptoms were noted in 7.7% of the cases. Most of the cases of anaphylaxis (338; 93.1%) were induced by foods. The most common trigger food was cow's milk and cow's milk products (43.8%), followed by hen's eggs (21.9%), walnuts (8.3%), wheat (7.7%), peanuts (4.8%), other nuts (3.0%), and fish (2.1%). In cow's milk-induced anaphylaxis cases, more than half the cases had cow's milk specific immunoglobulin E (sIgE) levels that were lower than the diagnostic decision points (DDPs), which is 5 kU

conclusionCow's milk is the most frequent trigger food of anaphylaxis in Korean infants. However, we found no significant correlation between the sIgE level and clinical severity. Education is required regarding the importance of epinephrine as the first line therapy for anaphylaxis and on properly prescribing epinephrine for infants with a history of anaphylaxis.

Indexed as

AllergensAnaphylaxisAnimalsBronchodilator AgentsChild, PreschoolEgg HypersensitivityEpinephrineFemaleHistamine AntagonistsHumansImmunoglobulin EInfantInfant, NewbornMaleMilkMilk HypersensitivityAllergensBronchodilator AgentsEpinephrineHistamine AntagonistsImmunoglobulin EAnaphylaxisEpinephrineFoodInfant

Identifiers

PMID30950251
PMCPMC6449600
OpenAlexW2926465877

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.