Evidence map›Paper›PMID 30950188›Full record

ArticleJournal of cellular and molecular medicine2019

SDF-1/CXCR4 signalling is involved in blood vessel growth and remodelling by intussusception.

Ivanka Dimova, Swapna Karthik, Andrew Makanya, Ruslan Hlushchuk, David Semela, Vladislav Volarevic, Valentin Djonov

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cellular and molecular medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 48 citations in OpenAlex.

  1. Review
  2. The cellular dance that splits vessels.Proceedings of the National Academy of Sciences of the United States of America · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 4 countries.

Ivanka DimovaInstitute of Anatomy, University of Bern, Bern, Switzerland.
Swapna KarthikInstitute of Anatomy, University of Bern, Bern, Switzerland.
Andrew MakanyaInstitute of Anatomy, University of Bern, Bern, Switzerland.
Ruslan HlushchukInstitute of Anatomy, University of Bern, Bern, Switzerland.
David SemelaLiver Biology Laboratory, Medical Research Center, Cantonal Hospital St. Gallen, St. Gallen, Switzerland.
Vladislav VolarevicInstitute of Anatomy, University of Bern, Bern, Switzerland.
Valentin DjonovInstitute of Anatomy, University of Bern, Bern, Switzerland.
University of Bern · CHUniversity of St.Gallen · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The precise mechanisms of SDF-1 (CXCL12) in angiogenesis are not fully elucidated. Recently, we showed that Notch inhibition induces extensive intussusceptive angiogenesis by recruitment of mononuclear cells and it was associated with increased levels of SDF-1 and CXCR4. In the current study, we demonstrated SDF-1 expression in liver sinusoidal vessels of Notch1 knockout mice with regenerative hyperplasia by means of intussusception, but we did not detect any SDF-1 expression in wild-type mice with normal liver vessel structure. In addition, pharmacological inhibition of SDF-1/CXCR4 signalling by AMD3100 perturbs intussusceptive vascular growth and abolishes mononuclear cell recruitment in the chicken area vasculosa. In contrast, treatment with recombinant SDF-1 protein increased microvascular density by 34% through augmentation of pillar number compared to controls. The number of extravasating mononuclear cells was four times higher after SDF-1 application and two times less after blocking this pathway. Bone marrow-derived mononuclear cells (BMDC) were recruited to vessels in response to elevated expression of SDF-1 in endothelial cells. They participated in formation and stabilization of pillars. The current study is the first report to implicate SDF-1/CXCR4 signalling in intussusceptive angiogenesis and further highlights the stabilizing role of BMDC in the formation of pillars during vascular remodelling.

Indexed as

AnimalsBenzylaminesBone Marrow CellsCell AdhesionChemokine CXCL12Chick EmbryoCyclamsEndothelial CellsHepatocytesHeterocyclic CompoundsIntussusceptionLeukocytes, MononuclearMaleMiceMice, Inbred C57BLMice, KnockoutBenzylaminesChemokine CXCL12Cxcl12 protein, mouseCXCR4 protein, mouseCyclamsHeterocyclic CompoundsNotch1 protein, mouseplerixaforReceptor, Notch1Receptors, CXCR4Recombinant Proteinsbone marrow-derived mononuclear cellsintussusceptive angiogenesisSDF-1/CXCR4 signallingvessel remodelling

Identifiers

PMID30950188
PMCPMC6533523
OpenAlexW2929298526

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.