Evidence map›Paper›PMID 30949970›Full record

ArticleJournal of the American Society for Mass Spectrometry2019

Fundamental Studies on Poly(2-oxazoline) Side Chain Isomers Using Tandem Mass Spectrometry and Ion Mobility-Mass Spectrometry.

Jean R N Haler, Victor R de la Rosa, Philippe Massonnet, Johann Far, Richard Hoogenboom, Edwin De Pauw

Abstract read
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In one paragraph

Article in Journal of the American Society for Mass Spectrometry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jean R N HalerMass Spectrometry Laboratory, MolSys Research unit, Quartier Agora, University of Liège, Allée du Six Aout 11, B-4000, Liège, Belgium. jean.haler@uliege.be.ORCID http://orcid.org/0000-0002-0315-1846
Victor R de la RosaSupramolecular Chemistry Group, Centre of Macromolecular Chemistry (CMaC), Department of Organic and Macromolecular Chemistry, Ghent University, Krijgslaan 281 S4, B-9000, Ghent, Belgium.
Philippe MassonnetMass Spectrometry Laboratory, MolSys Research unit, Quartier Agora, University of Liège, Allée du Six Aout 11, B-4000, Liège, Belgium.
Johann FarMass Spectrometry Laboratory, MolSys Research unit, Quartier Agora, University of Liège, Allée du Six Aout 11, B-4000, Liège, Belgium.
Richard HoogenboomSupramolecular Chemistry Group, Centre of Macromolecular Chemistry (CMaC), Department of Organic and Macromolecular Chemistry, Ghent University, Krijgslaan 281 S4, B-9000, Ghent, Belgium.
Edwin De PauwMass Spectrometry Laboratory, MolSys Research unit, Quartier Agora, University of Liège, Allée du Six Aout 11, B-4000, Liège, Belgium.

Funding

Fonds pour la Formation à la Recherche dans l'Industrie et dans l'Agriculture -Fonds Wetenschappelijk Onderzoek (BE) -Ghent University -
6 · The paper itself

Abstract

When polymer mixtures become increasingly complex, the conventional analysis techniques become insufficient for complete characterization. Mass spectrometric techniques can satisfy this increasing demand for detailed sample characterization. Even though isobaric polymers are indistinguishable using simple mass spectrometry (MS) analyses, more advanced techniques such as tandem MS (MS/MS) or ion mobility (IM) can be used. Here, we report proof of concept for characterizing isomeric polymers, namely poly(2-n-propyl-2-oxazoline) (Pn-PrOx) and poly(2-isopropyl-2-oxazoline) (Pi-PrOx), using MS/MS and IM-MS. Pi-PrOx ions lose in intensity at higher accelerating voltages than Pn-PrOx ions during collision-induced dissociation (CID) MS/MS experiments. A Pn/i-PrOx mixture could also be titrated using survival yield calculations of either precursor ions or cation ejection species. IM-MS yielded shape differences in the degree of polymerization (DP) regions showing the structural rearrangements. Combined MS techniques are thus able to identify and deconvolute the molar mass distributions of the two isomers in a mixture. Finally, the MS/MS and IM-MS behaviors are compared for interpretation. Graphical Abstract .

Indexed as

Collision-induced dissociationIon mobility-mass spectrometryPoly(2-oxazoline)sSynthetic polymer isomersTandem mass spectrometry MS/MS

Identifiers

PMID30949970

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.